A genopedia of lupus genes - Lessons from gene knockouts

Yuyuan Guo; Jacob Orme; Chandra Mohan

doi:10.2174/1573397111309020003

A genopedia of lupus genes - Lessons from gene knockouts

Yuyuan Guo, Jacob Orme, Chandra Mohan

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at http://www.mohanlab.org/SLE_BASE/gene.

Original language	English (US)
Pages (from-to)	90-99
Number of pages	10
Journal	Current Rheumatology Reviews
Volume	9
Issue number	2
DOIs	https://doi.org/10.2174/1573397111309020003
State	Published - Aug 28 2013

Keywords

Genetic susceptibility
Mouse models
Systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology

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10.2174/1573397111309020003

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abstract = "Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at http://www.mohanlab.org/SLE_BASE/gene.",

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AU - Orme, Jacob

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N2 - Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at http://www.mohanlab.org/SLE_BASE/gene.

AB - Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at http://www.mohanlab.org/SLE_BASE/gene.

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A genopedia of lupus genes - Lessons from gene knockouts

Abstract

Keywords

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