| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-256 |
| Number of pages | 9 |
| Journal | Biological Research For Nursing |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 4 2015 |
Keywords
- gene expression
- ischemic stroke
- recovery
ASJC Scopus subject areas
- Research and Theory
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In: Biological Research For Nursing, Vol. 17, No. 3, 04.05.2015, p. 248-256.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - A Genomic Profile of the Immune Response to Stroke With Implications for Stroke Recovery
AU - Barr, Taura L.
AU - VanGilder, Reyna
AU - Rellick, Stephanie
AU - Brooks, Steven D.
AU - Doll, Danielle N.
AU - Lucke-Wold, Ann Noelle
AU - Chen, Dongquan
AU - Denvir, James
AU - Warach, Steven
AU - Singleton, Andrew
AU - Matarin, Mar
N1 - Funding Information: In this prospective study, supported by the National Institutes of Health (NIH) and National Institute of Neurological Disorders and Stroke, we collected peripheral blood from ischemic stroke patients at two time points: 1–24 hr after stroke onset and 24–48 hr after stroke onset. Clinical evaluations and stroke outcome were collected at three time points: 0–24 hr after stroke onset, 24–48 hr after stroke onset, and 30 days after stroke onset. Recruitment was conducted from June 2007 through September 2008, as previously described (), after institutional review board approval was obtained. Patients ≥18 years of age with acute ischemic cerebrovascular syndrome (AICS; ) confirmed via magnetic resonance imaging were recruited from a hospital in Bethesda, MD, when they presented to the acute stroke team. Participants or their surrogates consented to enrollment in the study within 24 hr of known onset of symptoms. Severity of injury was determined by the National Institutes of Health Stroke Scale (NIHSS). Premorbid deficits and 30-day stroke outcome were determined by the Modified Rankin Scale (MRS). The MRS measures degree of disability following stroke on a 0–6 scale, from no symptoms (0) to death (6). Funding Information: Points of view in this document are those of the authors and do not necessarily represent the official position or views of the NIH. Taura Barr is a 2012 Robert Wood Johnson Foundation Nurse Faculty Scholar and a WVU Clinical and Translational Research Scholar, NIH/NIGMS award number U54GM104942. Acknowledgments Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Division of Intramural Research of the NIH/NINDS/NIA (Z01 AG000957-05), an Intramural Research Training Award via the Graduate Partnerships Program through the National Institute of Nursing Research, an NINR Contract # HHSN263201100872P, WVU Foundation funding, and a WV-INBRE grant P20 RR016477 from the NIH National Center for Research Resources, which supports the Appalachian Cardiovascular Research Network (to T.L.B.).
PY - 2015/5/4
Y1 - 2015/5/4
KW - gene expression
KW - ischemic stroke
KW - recovery
UR - http://www.scopus.com/inward/record.url?scp=84930408678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930408678&partnerID=8YFLogxK
U2 - 10.1177/1099800414546492
DO - 10.1177/1099800414546492
M3 - Article
C2 - 25124890
AN - SCOPUS:84930408678
SN - 1099-8004
VL - 17
SP - 248
EP - 256
JO - Biological Research For Nursing
JF - Biological Research For Nursing
IS - 3
ER -