@article{9c8212272aa34ba8bba25855a934aeb9,
title = "A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling",
abstract = "The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure α-amino acids (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly of exotic α-amino acids, including both unprecedented structures and those of established industrial value. The described method performs well in high-throughput library synthesis, and has already been implemented in three distinct medicinal chemistry campaigns.",
keywords = "amino acid synthesis, decarboxylative radical addition, library synthesis, redox-active esters, synthetic methods",
author = "Shengyang Ni and Garrido-Castro, {Alberto F.} and Merchant, {Rohan R.} and {de Gruyter}, {Justine N.} and Schmitt, {Daniel C.} and Mousseau, {James J.} and Gallego, {Gary M.} and Shouliang Yang and Collins, {Michael R.} and Qiao, {Jennifer X.} and Yeung, {Kap Sun} and Langley, {David R.} and Poss, {Michael A.} and Scola, {Paul M.} and Tian Qin and Baran, {Phil S.}",
note = "Funding Information: Financial support for this work was provided by NIH (grant number GM-118176), Pfizer, Bristol–Myers Squibb, and LEO Pharma. We gratefully thank China Scholarship Council (fellowship to S.N., Nanjing University, China), Universidad Aut{\'o}noma de Madrid (fellowship to A.F.G.-C.), Vividion Therapeutics (predoctoral fellowship to R.R.M), NSF GRFP (fellowship to J.N.D.). We also thank D.-H. Huang and L. Pasternack (Scripps Research) for assistance with NMR spectroscopy; J. S. Chen (Scripps Automated Synthesis Facility); A. Rheigold, C. E. Moore, and M. A. Galella (UCSD) for X-ray crystallographic analysis; D. Sun and D.-R. Wu (BMS) for SFC separation of the racemic mesitylsul-finamide and William R. Ewing for helpful discussions. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = oct,
day = "26",
doi = "10.1002/anie.201809310",
language = "English (US)",
volume = "57",
pages = "14560--14565",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "44",
}