TY - JOUR
T1 - A driving force for change
T2 - interstitial flow as a morphoregulator
AU - Rutkowski, Joseph M.
AU - Swartz, Melody A.
PY - 2007/1
Y1 - 2007/1
N2 - Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial flows, through the extracellular matrix. Interstitial flow not only helps to transport nutrients throughout the tissue, but also has important roles in tissue maintenance and pathobiology that have been, until recently, largely overlooked. Here, we present evidence for the various effects of interstitial flow on cell biology, including its roles in embryonic development, tissue morphogenesis and remodeling, inflammation and lymphedema, tumor biology and immune cell trafficking. We also discuss possible mechanisms by which interstitial flow can induce morphoregulation, including direct shear stress, matrix-cell transduction (as has been proposed in the endothelial glycocalyx) and the newly emerging concept of autologous gradient formation.
AB - Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial flows, through the extracellular matrix. Interstitial flow not only helps to transport nutrients throughout the tissue, but also has important roles in tissue maintenance and pathobiology that have been, until recently, largely overlooked. Here, we present evidence for the various effects of interstitial flow on cell biology, including its roles in embryonic development, tissue morphogenesis and remodeling, inflammation and lymphedema, tumor biology and immune cell trafficking. We also discuss possible mechanisms by which interstitial flow can induce morphoregulation, including direct shear stress, matrix-cell transduction (as has been proposed in the endothelial glycocalyx) and the newly emerging concept of autologous gradient formation.
UR - http://www.scopus.com/inward/record.url?scp=33845883279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845883279&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2006.11.007
DO - 10.1016/j.tcb.2006.11.007
M3 - Review article
C2 - 17141502
AN - SCOPUS:33845883279
SN - 0962-8924
VL - 17
SP - 44
EP - 50
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 1
ER -