A coralline hydroxyapatite bone graft substitute. Preliminary report

R. Holmes, V. Mooney, R. Bucholz, A. Tencer

Research output: Contribution to journalArticlepeer-review

273 Scopus citations


Experimental histologic and biochemical studies were perfored in 52 dogs by use of a bone substitute composed of hydroxyapatite converted from sea coral calcite. The results demonstrate some potentially useful practical applications. The material was totally incorporated in bone. Although initially too weak to tolerate physiologic stresses, once incorporated it becomes almost as strong as the native bone. Clinical experience with internal fixation of fractures with hydroxyapatite in 18 patients is encouraging.

Original languageEnglish (US)
Pages (from-to)252-262
Number of pages11
JournalClinical orthopaedics and related research
VolumeNO. 188
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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