A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines

P. Sharma; K. F. Hussain; S. Sukhwal; S. Kothari; M. Singhal; B. L. Verma

A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines

P. Sharma, K. F. Hussain, S. Sukhwal, S. Kothari, M. Singhal, B. L. Verma

Research output: Contribution to journal › Article › peer-review

Abstract

Variously substituted chalcones 1 on treatment with S-benzyl isothiouronium chloride in the presence of ethanol- morpholine/piperidine/pyrrolidine or DMF give 4,6-diaryl-2-(4-morpholinyl/1- piperidinyl/1-pyrrolidinyl) pyrimidines 4a-p and 2-benzyl-thiopyrimidines 3 a-e in a facile one step conversion. An alternate synthesis of 4g, h, j, k is also described.

Original language	English (US)
Pages (from-to)	966-968
Number of pages	3
Journal	Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume	38
Issue number	8
State	Published - Aug 1999
Externally published	Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

Cite this

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title = "A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines",

abstract = "Variously substituted chalcones 1 on treatment with S-benzyl isothiouronium chloride in the presence of ethanol- morpholine/piperidine/pyrrolidine or DMF give 4,6-diaryl-2-(4-morpholinyl/1- piperidinyl/1-pyrrolidinyl) pyrimidines 4a-p and 2-benzyl-thiopyrimidines 3 a-e in a facile one step conversion. An alternate synthesis of 4g, h, j, k is also described.",

author = "P. Sharma and Hussain, {K. F.} and S. Sukhwal and S. Kothari and M. Singhal and Verma, {B. L.}",

year = "1999",

month = aug,

language = "English (US)",

volume = "38",

pages = "966--968",

journal = "Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry",

issn = "0376-4699",

publisher = "Scientific Publishers of India",

number = "8",

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TY - JOUR

T1 - A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines

AU - Sharma, P.

AU - Hussain, K. F.

AU - Sukhwal, S.

AU - Kothari, S.

AU - Singhal, M.

AU - Verma, B. L.

PY - 1999/8

Y1 - 1999/8

N2 - Variously substituted chalcones 1 on treatment with S-benzyl isothiouronium chloride in the presence of ethanol- morpholine/piperidine/pyrrolidine or DMF give 4,6-diaryl-2-(4-morpholinyl/1- piperidinyl/1-pyrrolidinyl) pyrimidines 4a-p and 2-benzyl-thiopyrimidines 3 a-e in a facile one step conversion. An alternate synthesis of 4g, h, j, k is also described.

AB - Variously substituted chalcones 1 on treatment with S-benzyl isothiouronium chloride in the presence of ethanol- morpholine/piperidine/pyrrolidine or DMF give 4,6-diaryl-2-(4-morpholinyl/1- piperidinyl/1-pyrrolidinyl) pyrimidines 4a-p and 2-benzyl-thiopyrimidines 3 a-e in a facile one step conversion. An alternate synthesis of 4g, h, j, k is also described.

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UR - http://www.scopus.com/inward/citedby.url?scp=0033505373&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033505373

SN - 0376-4699

VL - 38

SP - 966

EP - 968

JO - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

JF - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

IS - 8

ER -

A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines

Abstract

ASJC Scopus subject areas

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