A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines

P. Sharma, K. F. Hussain, S. Sukhwal, S. Kothari, M. Singhal, B. L. Verma

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Variously substituted chalcones 1 on treatment with S-benzyl isothiouronium chloride in the presence of ethanol- morpholine/piperidine/pyrrolidine or DMF give 4,6-diaryl-2-(4-morpholinyl/1- piperidinyl/1-pyrrolidinyl) pyrimidines 4a-p and 2-benzyl-thiopyrimidines 3 a-e in a facile one step conversion. An alternate synthesis of 4g, h, j, k is also described.

Original languageEnglish (US)
Pages (from-to)966-968
Number of pages3
JournalIndian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Issue number8
StatePublished - Aug 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry


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