A controller for automatic regulation of induced paralysis during surgery

Khosrow Behbehani, Deepak Ramakrishna, Kevin Klein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


This paper presents a strategy for automatic control of induced paralysis using vecuronium bromide during surgery. The controller is self-tuning and adapts to inter-patient and intrapatient response variations while optimizing the output variance and infusion rate. In particular, the controller is capable of accommodating the variations of pure time delays in patient response. The performance of the controller is evaluated using an experimentally derived pharmacokinetic and nonlinear pharmacodynamic model of patient response. The results indicate that the controller provides robust regulation of the paralysis level with no output offset.

Original languageEnglish (US)
Pages (from-to)162-171
Number of pages10
JournalAnnals of Biomedical Engineering
Issue number2
StatePublished - Mar 1 1994

ASJC Scopus subject areas

  • Biomedical Engineering


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