A concise synthesis of 12(S),20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)- tetraenoic acid, an endogenous vasoconstrictor

S. G. Jagadeesh; L. Manmohan Reddy; Alberto Nasjletti; J R Falck

doi:10.1016/j.tetlet.2004.07.130

A concise synthesis of 12(S),20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)- tetraenoic acid, an endogenous vasoconstrictor

S. G. Jagadeesh, L. Manmohan Reddy, Alberto Nasjletti, J R Falck

Biochemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

12(S),20-DiHETE, prepared by a combination of Evans-Crimmins asymmetric alkylation, Sonogashira alkynation, and Suzuki-Miyaura cross-coupling, significantly sensitizes phenylephrine-induced vasoconstriction of rat renal interlobar arteries.

Original language	English (US)
Pages (from-to)	7111-7113
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	38
DOIs	https://doi.org/10.1016/j.tetlet.2004.07.130
State	Published - Sep 13 2004

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.07.130

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title = "A concise synthesis of 12(S),20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)- tetraenoic acid, an endogenous vasoconstrictor",

abstract = "12(S),20-DiHETE, prepared by a combination of Evans-Crimmins asymmetric alkylation, Sonogashira alkynation, and Suzuki-Miyaura cross-coupling, significantly sensitizes phenylephrine-induced vasoconstriction of rat renal interlobar arteries.",

author = "Jagadeesh, {S. G.} and Reddy, {L. Manmohan} and Alberto Nasjletti and Falck, {J R}",

note = "Funding Information: Supported financially by the USPHS NIH (DK38226, HL34300, GM31278) and the Robert A. Welch Foundation.",

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AU - Jagadeesh, S. G.

AU - Reddy, L. Manmohan

AU - Nasjletti, Alberto

AU - Falck, J R

N1 - Funding Information: Supported financially by the USPHS NIH (DK38226, HL34300, GM31278) and the Robert A. Welch Foundation.

PY - 2004/9/13

Y1 - 2004/9/13

N2 - 12(S),20-DiHETE, prepared by a combination of Evans-Crimmins asymmetric alkylation, Sonogashira alkynation, and Suzuki-Miyaura cross-coupling, significantly sensitizes phenylephrine-induced vasoconstriction of rat renal interlobar arteries.

AB - 12(S),20-DiHETE, prepared by a combination of Evans-Crimmins asymmetric alkylation, Sonogashira alkynation, and Suzuki-Miyaura cross-coupling, significantly sensitizes phenylephrine-induced vasoconstriction of rat renal interlobar arteries.

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A concise synthesis of 12(S),20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)- tetraenoic acid, an endogenous vasoconstrictor

Abstract

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