A comprehensive catalogue of somatic mutations in cancer genomes

Errol C. Friedberg

doi:10.1016/j.dnarep.2010.01.013

A comprehensive catalogue of somatic mutations in cancer genomes

Errol C. Friedberg

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes.

Original language	English (US)
Pages (from-to)	468-469
Number of pages	2
Journal	DNA repair
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.dnarep.2010.01.013
State	Published - Apr 4 2010

Keywords

Cancer genomes
Somatic mutations

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2010.01.013

Cite this

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title = "A comprehensive catalogue of somatic mutations in cancer genomes",

abstract = "This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes.",

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N2 - This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes.

AB - This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes.

KW - Cancer genomes

KW - Somatic mutations

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UR - http://www.scopus.com/inward/citedby.url?scp=77949656671&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2010.01.013

DO - 10.1016/j.dnarep.2010.01.013

M3 - Article

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AN - SCOPUS:77949656671

SN - 1568-7864

VL - 9

SP - 468

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JO - DNA repair

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ER -

A comprehensive catalogue of somatic mutations in cancer genomes

Abstract

Keywords

ASJC Scopus subject areas

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