A Comparison of Smoflipid® and Intralipid® in the Early Management of Infants with Intestinal Failure

Cameron Casson, Van Nguyen, Pritha Nayak, Nandini Channabasappa, Kaitlin Berris, Julia Panczuk, Cyrus Bhiladvala, Tisha Dasgupta, Hannah G. Piper

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose: Cholestasis is problematic for infants with intestinal failure (IF). The soy-based lipid Intralipid® (IL) has been implicated. An alternative, Smoflipid® (SMOF), is increasingly used. However, its role in cholestasis prevention is unclear. This study compares the incidence and degree of cholestasis between infants with IF receiving SMOF or IL. Methods: Infants with IF receiving SMOF or IL during the first 8 weeks of parenteral nutrition (PN) support between 2014 and 2017 were reviewed. Clinical characteristics, cholestasis incidence (conjugated bilirubin (Cbili) > 2 mg/dL for > 2 weeks), and nutritional parameters were compared using Welch's t-test. Results: 91% (21/23) of IL and 76% (16/21) of SMOF babies became cholestatic (p = 0.18). There was no significant difference in median peak Cbili, but SMOF babies normalized more quickly (p = 0.04). Median z-scores for weight were similar throughout the study. SMOF patients getting full PN had a lower incidence of cholestasis compared to IL patients (78% vs. 92%, p = 0.057), but those with cholestasis had similar peak Cbili, time to resolution, and growth. Conclusion: Early use of Smoflipid® did not reduce the incidence of cholestasis compared to Intralipid® in infants with IF, but hyperbilirubinemia did resolve more quickly. SMOF may be most beneficial for infants tolerating no enteral nutrition. Level of Evidence: Level III Retrospective Comparative Treatment Study. Type of Study: Retrospective Review.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalJournal of Pediatric Surgery
Issue number1
StatePublished - Jan 2020


  • Cholestasis
  • Intestinal failure-associated liver disease
  • Lipid emulsion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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