TY - JOUR
T1 - A collective form of cell death requires homeodomain interacting protein kinase
AU - Link, Nichole
AU - Chen, Po
AU - Lu, Wan Jin
AU - Pogue, Kristi
AU - Chuong, Amy
AU - Mata, Miguel
AU - Checketts, Joshua
AU - Abrams, John M.
PY - 2007/8/13
Y1 - 2007/8/13
N2 - We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers.
AB - We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers.
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U2 - 10.1083/jcb.200702125
DO - 10.1083/jcb.200702125
M3 - Article
C2 - 17682052
AN - SCOPUS:34547958738
SN - 0021-9525
VL - 178
SP - 567
EP - 574
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 4
ER -