@article{a320c00a24374e2d9b1d6d4c9ca75f1a,
title = "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes",
abstract = "Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model {"}system{"} to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.",
author = "Neve, {Richard M.} and Koei Chin and Jane Fridlyand and Jennifer Yeh and Baehner, {Frederick L.} and Tea Fevr and Laura Clark and Nora Bayani and Coppe, {Jean Philippe} and Frances Tong and Terry Speed and Spellman, {Paul T.} and Sandy DeVries and Anna Lapuk and Wang, {Nick J.} and Kuo, {Wen Lin} and Stilwell, {Jackie L.} and Daniel Pinkel and Albertson, {Donna G.} and Waldman, {Frederic M.} and Frank McCormick and Dickson, {Robert B.} and Johnson, {Michael D.} and Marc Lippman and Stephen Ethier and Adi Gazdar and Gray, {Joe W.}",
note = "Funding Information: This work was supported by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research (contract DE-AC03-76SF00098); the National Institutes of Health under grants CA 58207, CA112970, and CA090788; and the Avon Foundation. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. For full disclaimer, see http://www-library.lbl.gov/public/tmRco/howto/RcoBerkeleyLabDisclaimer.htm . ",
year = "2006",
month = dec,
doi = "10.1016/j.ccr.2006.10.008",
language = "English (US)",
volume = "10",
pages = "515--527",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",
}