A Circadian Sleep Disorder Reveals a Complex Clock

Emmanuel Mignot; Joseph S. Takahashi

doi:10.1016/j.cell.2006.12.024

A Circadian Sleep Disorder Reveals a Complex Clock

Emmanuel Mignot, Joseph S. Takahashi

Research output: Contribution to journal › Short survey › peer-review

23 Scopus citations

Abstract

Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1δ and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.

Original language	English (US)
Pages (from-to)	22-23
Number of pages	2
Journal	Cell
Volume	128
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2006.12.024
State	Published - Jan 12 2007

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2006.12.024

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title = "A Circadian Sleep Disorder Reveals a Complex Clock",

abstract = "Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1δ and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.",

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AU - Takahashi, Joseph S.

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N2 - Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1δ and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.

AB - Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1δ and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.

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A Circadian Sleep Disorder Reveals a Complex Clock

Abstract

ASJC Scopus subject areas

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