A chemical mismatch cleavage method useful for the detection of point mutations in the p53 gene in lung cancer.

Medicine & Life Sciences

• p53 Genes 100%
• Point Mutation 88%
• Lung Neoplasms 71%
• Mutation 50%
• Complementary DNA 36%
• DNA 33%
• DNA Sequence Analysis 30%
• Introns 29%
• alpha 1-Antitrypsin Deficiency 22%
• Denaturing Gradient Gel Electrophoresis 21%
• Neoplasms 19%
• Loss of Heterozygosity 17%
• Ribonucleases 16%
• Lung 16%
• Tumor Suppressor Genes 14%
• Codon 14%
• Cystic Fibrosis 14%
• Sequence Analysis 14%
• Lung Diseases 13%
• Non-Small Cell Lung Carcinoma 13%
• Genome 10%
• Polymerase Chain Reaction 8%
• Genes 6%

Chemical Compounds

• Mutation 76%
• Cleavage 61%
• DNA Sequencing 28%
• Denaturing Gradient Gel Electrophoresis 17%
• Complementary DNA 11%
• Disorder 9%
• Application 3%