A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

Mu Zhou; Zhihui Liu; Maxwell D. Melin; Yi Han Ng; Wei Xu; Thomas C. Südhof

doi:10.1038/s41593-018-0248-4

A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

Mu Zhou, Zhihui Liu, Maxwell D. Melin, Yi Han Ng, Wei Xu, Thomas C. Südhof

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64 Scopus citations

Abstract

The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

Original language	English (US)
Pages (from-to)	1515-1519
Number of pages	5
Journal	Nature neuroscience
Volume	21
Issue number	11
DOIs	https://doi.org/10.1038/s41593-018-0248-4
State	Published - Nov 1 2018

ASJC Scopus subject areas

General Neuroscience

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title = "A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory",

abstract = "The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.",

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AU - Zhou, Mu

AU - Liu, Zhihui

AU - Melin, Maxwell D.

AU - Ng, Yi Han

AU - Xu, Wei

AU - Südhof, Thomas C.

PY - 2018/11/1

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N2 - The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

AB - The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

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A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

Abstract

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