A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

Gervaise H. Henry; Alicia Malewska; Diya B. Joseph; Venkat S. Malladi; Jeon Lee; Jose R Torrealba; Ryan Mauck; Jeffrey Gahan; Ganesh Raj; Claus Roehrborn; Gary Hon; Malcolm P MacConmara; Jeffrey C. Reese; Ryan Craig Hutchinson; Chad M. Vezina; Douglas W Strand

doi:10.1016/j.celrep.2018.11.086

A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

Gervaise H. Henry, Alicia Malewska, Diya B. Joseph, Venkat S. Malladi, Jeon Lee, Jose R Torrealba, Ryan Mauck, Jeffrey Gahan, Ganesh Raj, Claus Roehrborn, Gary Hon, Malcolm P MacConmara, Jeffrey C. Reese, Ryan Craig Hutchinson, Chad M. Vezina, Douglas W Strand

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

Using single-cell RNA sequencing, immunofluorescence, and flow cytometry, Henry et al. create a cellular anatomy of the normal human prostate and provide the tools to identify, isolate, and localize every cell type. They identify two additional epithelial cell types enriched in the prostatic urethra and proximal prostatic ducts.

Original language	English (US)
Pages (from-to)	3530-3542.e5
Journal	Cell Reports
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2018.11.086
State	Published - Dec 18 2018

Keywords

GUDMAP
benign prostatic hyperplasia
flow cytometry
human cell atlas
human prostate
prostate cancer
prostate epithelia
prostate stroma
single-cell RNA sequencing
zonal anatomy

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.11.086

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Henry, G. H., Malewska, A., Joseph, D. B., Malladi, V. S., Lee, J., Torrealba, J. R., Mauck, R., Gahan, J., Raj, G., Roehrborn, C., Hon, G., MacConmara, M. P., Reese, J. C., Hutchinson, R. C., Vezina, C. M., & Strand, D. W. (2018). A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. Cell Reports, 25(12), 3530-3542.e5. https://doi.org/10.1016/j.celrep.2018.11.086

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abstract = "Using single-cell RNA sequencing, immunofluorescence, and flow cytometry, Henry et al. create a cellular anatomy of the normal human prostate and provide the tools to identify, isolate, and localize every cell type. They identify two additional epithelial cell types enriched in the prostatic urethra and proximal prostatic ducts.",

keywords = "GUDMAP, benign prostatic hyperplasia, flow cytometry, human cell atlas, human prostate, prostate cancer, prostate epithelia, prostate stroma, single-cell RNA sequencing, zonal anatomy",

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AU - Henry, Gervaise H.

AU - Malewska, Alicia

AU - Joseph, Diya B.

AU - Malladi, Venkat S.

AU - Lee, Jeon

AU - Torrealba, Jose R

AU - Mauck, Ryan

AU - Gahan, Jeffrey

AU - Raj, Ganesh

AU - Roehrborn, Claus

AU - Hon, Gary

AU - MacConmara, Malcolm P

AU - Reese, Jeffrey C.

AU - Hutchinson, Ryan Craig

AU - Vezina, Chad M.

AU - Strand, Douglas W

PY - 2018/12/18

Y1 - 2018/12/18

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AB - Using single-cell RNA sequencing, immunofluorescence, and flow cytometry, Henry et al. create a cellular anatomy of the normal human prostate and provide the tools to identify, isolate, and localize every cell type. They identify two additional epithelial cell types enriched in the prostatic urethra and proximal prostatic ducts.

KW - GUDMAP

KW - benign prostatic hyperplasia

KW - flow cytometry

KW - human cell atlas

KW - human prostate

KW - prostate cancer

KW - prostate epithelia

KW - prostate stroma

KW - single-cell RNA sequencing

KW - zonal anatomy

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A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

Abstract

Keywords

ASJC Scopus subject areas

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