A cascade of multiple proteins and lipids catalyzes membrane fusion

William Wickner; Jose Rizo-Rey

doi:10.1091/mbc.E16-07-0517

A cascade of multiple proteins and lipids catalyzes membrane fusion

William Wickner, Jose Rizo-Rey

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.

Original language	English (US)
Pages (from-to)	707-711
Number of pages	5
Journal	Molecular biology of the cell
Volume	28
Issue number	6
DOIs	https://doi.org/10.1091/mbc.E16-07-0517
State	Published - Mar 15 2017

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1091/mbc.E16-07-0517

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AB - Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.

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A cascade of multiple proteins and lipids catalyzes membrane fusion

Abstract

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