Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.
|Original language||English (US)|
|Number of pages||5|
|Journal||Molecular biology of the cell|
|State||Published - Mar 15 2017|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology