A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis

Shang Ma, Devi Santhosh, Peeyush Kumar T., Zhen Huang

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Intimate communication between neural and vascular cells is critical for normal brain development and function. Germinal matrix (GM), a key primordium for the brain reward circuitry, is unique among brain regions for its distinct pace of angiogenesis and selective vulnerability to hemorrhage during development. A major neonatal condition, GM hemorrhage can lead to cerebral palsy, hydrocephalus, and mental retardation. Here we identify a brain-region-specific neural progenitor-based signaling pathway dedicated to regulating GM vessel development. This pathway consists of cell-surface sphingosine-1-phosphate receptors, an intracellular cascade including Gα co-factor Ric8a and p38 MAPK, and target gene integrin β8, which in turn regulates vascular TGF-β signaling. These findings provide insights into region-specific specialization of neurovascular communication, with special implications for deciphering potent early-life endocrine, as well as potential gut microbiota impacts on brain reward circuitry. They also identify tissue-specific molecular targets for GM hemorrhage intervention.

Original languageEnglish (US)
Pages (from-to)366-381.e4
JournalDevelopmental cell
Issue number4
StatePublished - May 22 2017
Externally publishedYes


  • angiogenesis
  • basal ganglia
  • G-protein-coupled receptor
  • germinal matrix
  • integrin
  • neural stem cell
  • neurovascular signaling
  • radial glia
  • sphigosine-1-phosphate
  • TGF

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis'. Together they form a unique fingerprint.

Cite this