A Biomechanical Modeling Guided CBCT Estimation Technique

You Zhang, Joubin Nasehi Tehrani, Jing Wang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Two-dimensional-to-three-dimensional (2D-3D) deformation has emerged as a new technique to estimate cone-beam computed tomography (CBCT) images. The technique is based on deforming a prior high-quality 3D CT/CBCT image to form a new CBCT image, guided by limited-view 2D projections. The accuracy of this intensity-based technique, however, is often limited in low-contrast image regions with subtle intensity differences. The solved deformation vector fields (DVFs) can also be biomechanically unrealistic. To address these problems, we have developed a biomechanical modeling guided CBCT estimation technique (Bio-CBCT-est) by combining 2D-3D deformation with finite element analysis (FEA)-based biomechanical modeling of anatomical structures. Specifically, Bio-CBCT-est first extracts the 2D-3D deformation-generated displacement vectors at the high-contrast anatomical structure boundaries. The extracted surface deformation fields are subsequently used as the boundary conditions to drive structure-based FEA to correct and fine-tune the overall deformation fields, especially those at low-contrast regions within the structure. The resulting FEA-corrected deformation fields are then fed back into 2D-3D deformation to form an iterative loop, combining the benefits of intensity-based deformation and biomechanical modeling for CBCT estimation. Using eleven lung cancer patient cases, the accuracy of the Bio-CBCT-est technique has been compared to that of the 2D-3D deformation technique and the traditional CBCT reconstruction techniques. The accuracy was evaluated in the image domain, and also in the DVF domain through clinician-tracked lung landmarks.

Original languageEnglish (US)
Article number7728145
Pages (from-to)641-652
Number of pages12
JournalIEEE Transactions on Medical Imaging
Issue number2
StatePublished - Feb 2017


  • 2D-3D deformation
  • Mooney-Rivlin material
  • biomechanicalmodeling
  • boundarycondition
  • cone-beamcomputedtomography
  • finite element analysis
  • image estimation

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


Dive into the research topics of 'A Biomechanical Modeling Guided CBCT Estimation Technique'. Together they form a unique fingerprint.

Cite this