Abstract
RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies suggest that P-TEFb (as part of the inhibitory 7SK snRNP) is recruited to promoter-proximal regions through interaction with KAP1/TRIM28/TIF1β to facilitate ‘on-site’ kinase activation and transcription elongation. Here, I discuss features of this model and future challenges to further hone our understanding of transcriptional regulation including Pol II pausing and pause release.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 545-553 |
| Number of pages | 9 |
| Journal | RNA Biology |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2 2016 |
Keywords
- 7SK snRNP
- KAP1/TRIM28
- P-TEFb
- RNA polymerase II
- transcription elongation
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology