3D Printing of Poloxamer 407 Nanogel Discs and Their Applications in Adjuvant Ovarian Cancer Therapy

Hyunah Cho; Udayabhanu Jammalamadaka; Karthik Tappa; Christopher Egbulefu; Julie Prior; Rui Tang; Samuel Achilefu

doi:10.1021/acs.molpharmaceut.8b00836

3D Printing of Poloxamer 407 Nanogel Discs and Their Applications in Adjuvant Ovarian Cancer Therapy

Hyunah Cho, Udayabhanu Jammalamadaka, Karthik Tappa, Christopher Egbulefu, Julie Prior, Rui Tang, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter × 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.

Original language	English (US)
Pages (from-to)	552-560
Number of pages	9
Journal	Molecular Pharmaceutics
Volume	16
Issue number	2
DOIs	https://doi.org/10.1021/acs.molpharmaceut.8b00836
State	Published - Feb 4 2019
Externally published	Yes

Keywords

3D printing
ovarian cancer
paclitaxel
peritoneal adhesion
poloxamer

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

Access to Document

10.1021/acs.molpharmaceut.8b00836

Cite this

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abstract = "Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter × 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.",

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AU - Egbulefu, Christopher

AU - Prior, Julie

AU - Tang, Rui

AU - Achilefu, Samuel

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AB - Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter × 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.

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3D Printing of Poloxamer 407 Nanogel Discs and Their Applications in Adjuvant Ovarian Cancer Therapy

Abstract

Keywords

ASJC Scopus subject areas

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