27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring: Atherogenesis

Chieko Mineo; Philip W. Shaul

doi:10.1038/s44161-025-00631-3

27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring: Atherogenesis

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Maternal hypercholesterolemia can exaggerate the development of atherosclerosis in adult offspring. Research now shows that the cholesterol metabolite 27-hydroxycholesterol invokes AP-1-mediated immune memory in progeny endothelial cells to increase vascular inflammation and atherosclerosis severity in adulthood.

Original language	English (US)
Article number	4101
Pages (from-to)	350-352
Number of pages	3
Journal	Nature Cardiovascular Research
Volume	4
Issue number	4
DOIs	https://doi.org/10.1038/s44161-025-00631-3
State	Published - Apr 2025

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell Biology
Medicine (miscellaneous)
Cardiology and Cardiovascular Medicine

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10.1038/s44161-025-00631-3

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title = "27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring: Atherogenesis",

abstract = "Maternal hypercholesterolemia can exaggerate the development of atherosclerosis in adult offspring. Research now shows that the cholesterol metabolite 27-hydroxycholesterol invokes AP-1-mediated immune memory in progeny endothelial cells to increase vascular inflammation and atherosclerosis severity in adulthood.",

author = "Chieko Mineo and Shaul, {Philip W.}",

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AU - Shaul, Philip W.

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AB - Maternal hypercholesterolemia can exaggerate the development of atherosclerosis in adult offspring. Research now shows that the cholesterol metabolite 27-hydroxycholesterol invokes AP-1-mediated immune memory in progeny endothelial cells to increase vascular inflammation and atherosclerosis severity in adulthood.

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27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring: Atherogenesis

Abstract

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