Research output per year
Research output per year
- 19 results
Search results
-
2018
Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer
Belzile, O., Huang, X., Gong, J., Carlson, J., Schroit, A. J., Brekken, R. A. & Freimark, B. D., 2018, In: ImmunoTargets and Therapy. 7, p. 1-14 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access23 Scopus citations -
2017
Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies
Sharma, R., Huang, X., Brekken, R. A. & Schroit, A. J., Aug 8 2017, In: British journal of cancer. 117, 4, p. 545-552 8 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
2016
Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts
Cheng, X., Li, L., Thorpe, P. E., Yopp, A. C., Brekken, R. A. & Huang, X., Dec 1 2016, In: Annals of Surgical Oncology. 23, p. 583-591 9 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Antibody-Mediated phosphatidylserine blockade enhances the antitumor responses to CTLA-4 and PD-1 antibodies in melanoma
Freimark, B. D., Gong, J., Ye, D., Gray, M. J., Nguyen, V., Yin, S., Hatch, M. M. S., Hughes, C. C. W., Schroit, A. J., Hutchins, J. T., Brekken, R. A. & Huang, X., Jun 2016, In: Cancer Immunology Research. 4, 6, p. 531-540 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis
Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y. M., Salmon, J. E., Brekken, R. A., Huang, X., Thorpe, P. E. & Shaul, P. W., Jul 2016, In: PloS one. 11, 7, e0158757.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Birge, R. B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J., Calianese, D., Barcinski, M., Brekken, R. A., Huang, X., Hutchins, J. T., Freimark, B., Empig, C., Mercer, J., Schroit, A. J., Schett, G. & Herrmann, M., Jun 1 2016, In: Cell Death and Differentiation. 23, 6, p. 962-978 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access454 Scopus citations -
2015
Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
Jiang, L., Xiao, L., Sugiura, H., Huang, X., Ali, A., Kuro-O, M., DeBerardinis, R. J. & Boothman, D. A., Jul 23 2015, In: Oncogene. 34, 30, p. 3908-3916 9 p.Research output: Contribution to journal › Article › peer-review
Open Access164 Scopus citations -
Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium: PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo
Li, T., Aredo, B., Zhang, K., Zhong, X., Pulido, J. S., Wang, S., He, Y. G., Huang, X., Brekken, R. A. & Ufret-Vincenty, R. L., Nov 1 2015, In: Investigative Ophthalmology and Visual Science. 56, 12, p. 7137-7145 9 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2013
Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation
Yin, Y., Huang, X., Lynn, K. D. & Thorpe, P. E., Oct 1 2013, In: Cancer Immunology Research. 1, 4, p. 256-268 13 p.Research output: Contribution to journal › Article › peer-review
Open Access118 Scopus citations -
2011
Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine
Huang, X., Ye, D. & Thorpe, P. E., Jun 24 2011, In: Vaccine. 29, 29-30, p. 4785-4793 9 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
2006
Plasma protein β-2-glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cells
Luster, T. A., He, J., Huang, X., Maiti, S. N., Schroit, A. J., De Groot, P. G. & Thorpe, P. E., Oct 6 2006, In: Journal of Biological Chemistry. 281, 40, p. 29863-29871 9 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
2005
A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice
Huang, X., Bennett, M. & Thorpe, P. E., May 15 2005, In: Cancer research. 65, 10, p. 4408-4416 9 p.Research output: Contribution to journal › Article › peer-review
123 Scopus citations -
Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice
Ran, S., He, J., Huang, X., Soares, M., Scothorn, D. & Thorpe, P. E., Feb 15 2005, In: Clinical Cancer Research. 11, 4, p. 1551-1562 12 p.Research output: Contribution to journal › Article › peer-review
131 Scopus citations -
2004
Anti-tumor effects and lack of side effects in mice of an immunotoxin directed against human and mouse prostate-specific membrane antigen
Huang, X., Bennett, M. & Thorpe, P. E., Sep 15 2004, In: Prostate. 61, 1, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
2003
Evaluation of novel antimouse VEGFR2 antibodies as potential antiangiogenic or vascular targeting agents for tumor therapy
Ran, S., Huang, X., Downes, A. & Thorpe, P. E., 2003, In: Neoplasia. 5, 4, p. 297-307 11 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2002
A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model
Zhang, W., Ran, S., Sambade, M., Huang, X. & Thorpe, P. E., 2002, In: Angiogenesis. 5, 1-2, p. 35-44 10 p.Research output: Contribution to journal › Article › peer-review
102 Scopus citations -
1998
Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonance
Huang, X., Gottstein, C., Brekken, R. A. & Thorpe, P. E., Nov 27 1998, In: Biochemical and Biophysical Research Communications. 252, 3, p. 643-648 6 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Vascular endothelial growth factor as a marker of tumor endothelium
Brekken, R. A., Huang, X., King, S. W. & Thorpe, P. E., May 1 1998, In: Cancer research. 58, 9, p. 1952-1959 8 p.Research output: Contribution to journal › Article › peer-review
169 Scopus citations -
1997
Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S. & Thorpe, P. E., Jan 24 1997, In: Science. 275, 5299, p. 547-550 4 p.Research output: Contribution to journal › Article › peer-review
474 Scopus citations