The Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research

Research output

Research output per year 1967 1978 1979 1985 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2018 2019 2020 2021 2022 2024

• 826 Article
• 67 Review article
• 40 Comment/debate
• 20 Chapter
• 40 More
  • 17 Editorial
  • 13 Letter
  • 6 Short survey
  • 2 Conference contribution
  • 1 Book
  • 1 Conference article

Research output per year

Research output per year

Search results

• 2024

  A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer

  Eglenen-Polat, B., Kowash, R. R., Huang, H. C., Siteni, S., Zhu, M., Chen, K., Bender, M. E., Mender, I., Stastny, V., Drapkin, B. J., Raj, P., Minna, J. D., Xu, L., Shay, J. W. & Akbay, E. A., Dec 2024, In: Nature communications. 15, 1, 672.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-2'-deoxythioguanosine 100%
  • telomeres 89%
  • Nucleoside Analogue 64%
  • immunity 61%
  • Small Cell Lung Carcinoma 58%

• Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

  Kim, C., Wang, X. D., Liu, Z., Hao, J., Wang, S., Li, P., Zi, Z., Ding, Q., Jang, S., Kim, J., Luo, Y., Huffman, K. E., Choudhuri, S. P., del Rio, S., Cai, L., Liang, H., Drapkin, B. J., Minna, J. D. & Yu, Y., Jan 2024, In: Science Advances. 10, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(ADP-ribose) Polymerase Inhibitors 100%
  • Oncogene Proteins 84%
  • Small Cell Lung Carcinoma 83%
  • Proteomics 15%
  • Therapeutics 12%

• The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β-catenin signaling in lung cancer

  Sunaga, N., Kaira, K., Shimizu, K., Tanaka, I., Miura, Y., Nakazawa, S., Ohtaki, Y., Kawabata-Iwakawa, R., Sato, M., Girard, L., Minna, J. D. & Hisada, T., Jan 2024, In: Thoracic Cancer. 15, 2, p. 131-141 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Catenins 100%
  • Lung Neoplasms 62%
  • Non-Small Cell Lung Carcinoma 42%
  • Cell Line 37%
  • Large Cell Carcinoma 20%
• 2023

  A comparative study of neuroendocrine heterogeneity in small cell lung cancer and neuroblastoma

  Cai, L., De Berardinis, R. J., Xie, Y., Minna, J. D. & Xiao, G., Aug 1 2023, In: Molecular Cancer Research. 21, 8, p. 795-807 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • Neuroblastoma 89%
  • myc Genes 22%
  • Cell Line 21%
  • Drug Resistance 16%

• CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

  Nilsson, M. B., Yang, Y., Heeke, S., Patel, S. A., Poteete, A., Udagawa, H., Elamin, Y. Y., Moran, C. A., Kashima, Y., Arumugam, T., Yu, X., Ren, X., Diao, L., Shen, L., Wang, Q., Zhang, M., Robichaux, J. P., Shi, C., Pfeil, A. N., Tran, H., & 7 othersGibbons, D. L., Bock, J., Wang, J., Minna, J. D., Kobayashi, S. S., Le, X. & Heymach, J. V., Feb 13 2023, In: Cancer Cell. 41, 2, p. 340-355.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epithelial-Mesenchymal Transition 100%
  • ErbB Receptors 91%
  • Protein-Tyrosine Kinases 87%
  • Chimeric Antigen Receptors 51%
  • Immunoconjugates 25%
  21 Scopus citations

• Deep learning of cell spatial organizations identifies clinically relevant insights in tissue images

  Wang, S., Rong, R., Zhou, Q., Yang, D. M., Zhang, X., Zhan, X., Bishop, J., Chi, Z., Wilhelm, C. J., Zhang, S., Pickering, C. R., Kris, M. G., Minna, J., Xie, Y. & Xiao, G., Dec 2023, In: Nature communications. 14, 1, 7872.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tyrosine Kinase Inhibitor 100%
  • Deep Learning 98%
  • learning 77%
  • Biological Marker 64%
  • Disorder 61%

• Dissecting molecular, pathological, and clinical features associated with tumor neural/neuroendocrine heterogeneity

  Cai, L., DeBerardinis, R. J., Xiao, G., Minna, J. D. & Xie, Y., Jun 16 2023, In: iScience. 26, 6, 106983.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Tumors 100%
  • Neoplasms 28%
  • Datasets 15%

• Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer

  Wang, S., Rong, R., Yang, D. M., Fujimoto, J., Bishop, J. A., Yan, S., Cai, L., Behrens, C., Berry, L. D., Wilhelm, C., Aisner, D., Sholl, L., Johnson, B. E., Kwiatkowski, D. J., Wistuba, I. I., Bunn, P. A., Minna, J., Xiao, G., Kris, M. G. & Xie, Y., Jan 17 2023, In: Journal of Clinical Investigation. 133, 2, e160330.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Microenvironment 100%
  • ErbB Receptors 91%
  • Lung Neoplasms 76%
  • Protein-Tyrosine Kinases 68%
  • Survival 53%
  5 Scopus citations

• Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers

  Huffman, K. E., Li, L. S., Carstens, R., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R., Timmons, B., Sudderth, J., Bendris, N., Kim, J., Villalobos, P., Fujimoto, J., Schmid, S., Deberardinis, R. J., Wistuba, I., Heymach, J., Kittler, R., Akbay, E. A., & 6 othersPosner, B., Wang, Y., Lam, S., Kliewer, S. A., Mangelsdorf, D. J. & Minna, J. D., 2023, In: Frontiers in Oncology. 13, 1025443.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucocorticoids 100%
  • Non-Small Cell Lung Carcinoma 98%
  • Glucocorticoid Receptors 87%
  • Dexamethasone 72%
  • dexamethasone receptor 52%
  2 Scopus citations

• IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells

  Nawas, A. F., Solmonson, A., Gao, B., DeBerardinis, R. J., Minna, J. D., Conacci-Sorrell, M. & Mendelson, C. R., Dec 2023, In: Cell Communication and Signaling. 21, 1, 331.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Indoleamine-Pyrrole 2,3,-Dioxygenase 100%
  • Kynurenine 80%
  • Adenocarcinoma of Lung 78%
  • Interleukin-1 73%
  • Tryptophan 68%
  1 Scopus citations

• Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden

  Zhu, M., Kim, J., Deng, Q., Ricciuti, B., Alessi, J. V., Eglenen-Polat, B., Bender, M. E., Huang, H. C., Kowash, R. R., Cuevas, I., Bennett, Z. T., Gao, J., Minna, J. D., Castrillon, D. H., Awad, M. M., Xu, L. & Akbay, E. A., Oct 9 2023, In: Cancer Cell. 41, 10, p. 1731-1748.e8

  Research output: Contribution to journal › Article › peer-review

  • Tumor Burden 100%
  • Lung Neoplasms 83%
  • Immunotherapy 46%
  • Neoplasms 33%
  • DNA-Directed DNA Polymerase 29%
  3 Scopus citations

• MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

  Qian, Y., Galan-Cobo, A., Guijarro, I., Dang, M., Molkentine, D., Poteete, A., Zhang, F., Wang, Q., Wang, J., Parra, E., Panda, A., Fang, J., Skoulidis, F., Wistuba, I. I., Verma, S., Merghoub, T., Wolchok, J. D., Wong, K. K., DeBerardinis, R. J., Minna, J. D., & 6 othersVokes, N. I., Meador, C. B., Gainor, J. F., Wang, L., Reuben, A. & Heymach, J. V., Jul 10 2023, In: Cancer Cell. 41, 7, p. 1363-1380.e7

  Research output: Contribution to journal › Article › peer-review

  • Adenocarcinoma of Lung 100%
  • Lactic Acid 83%
  • Immunity 76%
  • Immunotherapy 41%
  • Macrophages 32%
  8 Scopus citations

• Silencing of GRHL2 induces epithelial-to-mesenchymal transition in lung cancer cell lines with different effects on proliferation and clonogenic growth

  Kawabe, N., Matsuoka, K., Komeda, K., Muraki, N., Takaba, M., Togami, Y., Ito, Y., Yamada, M., Sunaga, N., Girard, L., Minna, J. D., Cai, L., Xie, Y., Tanaka, I., Morise, M. & Sato, M., Oct 2023, In: Oncology Letters. 26, 3, 391.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epithelial-Mesenchymal Transition 100%
  • Lung Neoplasms 76%
  • Cell Line 57%
  • Growth 48%
  • Datasets 43%
  1 Scopus citations

• Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer

  Malchers, F., Nogova, L., van Attekum, M. H. A., Maas, L., Brägelmann, J., Bartenhagen, C., Girard, L., Bosco, G., Dahmen, I., Michels, S., Weeden, C. E., Scheel, A. H., Meder, L., Golfmann, K., Schuldt, P., Siemanowski, J., Rehker, J., Merkelbach-Bruse, S., Menon, R., Gautschi, O., & 14 othersHeuckmann, J. M., Brambilla, E., Asselin-Labat, M. L., Persigehl, T., Minna, J. D., Walczak, H., Ullrich, R. T., Fischer, M., Reinhardt, H. C., Wolf, J., Büttner, R., Peifer, M., George, J. & Thomas, R. K., Nov 1 2023, In: Journal of Clinical Investigation. 133, 21, e174171.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Squamous Cell Neoplasms 100%
  • Lung Neoplasms 63%
  • Exons 22%
  • Phosphotransferases 20%
  • Clinical Trials 17%
  3 Scopus citations

• Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution

  Zhang, H., Yu, X., Ye, J., Li, H., Hu, J., Tan, Y., Fang, Y., Akbay, E., Yu, F., Weng, C., Sankaran, V. G., Bachoo, R. M., Maher, E., Minna, J., Zhang, A. & Li, B., Oct 9 2023, In: Cancer Cell. 41, 10, p. 1788-1802.e10

  Research output: Contribution to journal › Article › peer-review

  • T-Lymphocytes 100%
  • Mitochondria 57%
  • Neoplasms 52%
  • Cell Communication 43%
  • Immune Evasion 29%
  1 Scopus citations

• Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

  Iyengar, P., Gandhi, A. Y., Granados, J., Guo, T., Gupta, A., Yu, J., Llano, E. M., Zhang, F., Gao, A., Kandathil, A., Williams, D., Gao, B., Girard, L., Malladi, V. S., Shelton, J. M., Evers, B. M., Hannan, R., Ahn, C., Minna, J. D. & Infante, R. E., 2023, In: JCI Insight. 8, 8, e165419.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cachexia 100%
  • Loss of Function Mutation 92%
  • Non-Small Cell Lung Carcinoma 41%
  • Wasting Syndrome 32%
  • Neoplasms 26%
  2 Scopus citations
• 2022

  A Pan-Cancer Assessment of RB1/TP53 Co-Mutations

  Cai, L., DeBerardinis, R. J., Xiao, G., Minna, J. D. & Xie, Y., Sep 2022, In: Cancers. 14, 17, 4199.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Neoplasms 57%
  • Neuroendocrine Carcinoma 23%
  • Small Cell Carcinoma 21%
  • Translational Medical Research 20%
  4 Scopus citations

• AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1⁺ CD8 T cells

  Li, H., Liu, Z., Liu, L., Zhang, H., Han, C., Girard, L., Park, H., Zhang, A., Dong, C., Ye, J., Rayford, A., Peyton, M., Li, X., Avila, K., Cao, X., Hu, S., Alam, M. M., Akbay, E. A., Solis, L. M., Behrens, C., & 13 othersHernandez-Ruiz, S., Lu, W., Wistuba, I., Heymach, J. V., Chisamore, M., Micklem, D., Gabra, H., Gausdal, G., Lorens, J. B., Li, B., Fu, Y. X., Minna, J. D. & Brekken, R. A., Mar 15 2022, In: Cell Reports Medicine. 3, 3, 100554.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Small Cell Lung Carcinoma 100%
  • Mutation 94%
  • T-Lymphocytes 69%
  • pembrolizumab 39%
  • Refractory 38%
  38 Scopus citations

• Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado

  Galan-Cobo, A., Stellrecht, C. M., Yilmaz, E., Yang, C., Qian, Y., Qu, X., Akhter, I., Ayres, M. L., Fan, Y., Tong, P., Diao, L., Ding, J., Giri, U., Gudikote, J., Nilsson, M., Wierda, W. G., Wang, J., Skoulidis, F., Minna, J. D., Gandhi, V., & 1 othersHeymach, J. V., Feb 2022, In: Molecular Cancer Research. 20, 2, p. 280-292 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenosine 100%
  • Oxidation-Reduction 97%
  • Non-Small Cell Lung Carcinoma 91%
  • Adenosine Triphosphate 79%
  • Homeostasis 74%
  3 Scopus citations

• Establishment of reference standards for multifaceted mosaic variant analysis

  Ha, Y. J., Oh, M. J., Kim, J., Kim, J., Kang, S., Minna, J. D., Kim, H. S. & Kim, S., Dec 2022, In: Scientific Data. 9, 1, 35.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Line 100%
  • Cells 85%
  • Cell 64%
  • Nucleotides 54%
  • Standards 48%
  2 Scopus citations

• High-throughput functional evaluation of human cancer-associated mutations using base editors

  Kim, Y., Lee, S., Cho, S., Park, J., Chae, D., Park, T., Minna, J. D. & Kim, H. H., Jun 2022, In: Nature biotechnology. 40, 6, p. 874-884 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA 100%
  • Guide RNA 86%
  • Proteins 75%
  • Mutation 70%
  • Throughput 57%
  20 Scopus citations

• Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

  Pongor, L. S., Tlemsani, C., Elloumi, F., Arakawa, Y., Jo, U., Gross, J. M., Mosavarpour, S., Varma, S., Kollipara, R. K., Roper, N., Teicher, B. A., Aladjem, M. I., Reinhold, W., Thomas, A., Minna, J. D., Johnson, J. E. & Pommier, Y., Nov 18 2022, In: iScience. 25, 11, 105338.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • Methylation 81%
  • Epigenomics 78%
  • Genes 36%
  • DNA Methylation 35%
  7 Scopus citations

• Lung Cancer Cell of Origin: Controversy and Clinical Translational Implications

  Osborne, J. K. & Minna, J. D., Mar 15 2022, In: Cancer research. 82, 6, p. 972-973 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lung Neoplasms 100%
  • Alveolar Epithelial Cells 28%
  • Chemoprevention 28%
  • Adenocarcinoma of Lung 27%
  • Stem Cells 18%

• Lung Cancer Computational Biology and Resources

  Cai, L., Xiao, G., Gerber, D., Minna, J. D. & Xie, Y., Feb 2022, In: Cold Spring Harbor Perspectives in Biology. 12, 2, a038273.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Computational Biology 100%
  • Lung Neoplasms 84%
  • Translational Medical Research 60%
  • Datasets 42%
  • Artificial Intelligence 35%

• Rare solid and cystic presentation of hemangiopericytoma/ solitary fibrous tumor: A case report

  Hayenga, H. N., Cai, C., Fetzer, D., White, S., Kuban, J., Wardak, Z., Benjamin, R. S., Pan, E., Strauss, J., Gao, B., Minna, J., Martin-Broto, J. & Hinshaw, J. L., Jun 2022, In: Current Problems in Cancer: Case Reports. 6, 100149.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Solitary Fibrous Tumors 100%
  • Hemangiopericytoma 97%
  • Liver 20%
  • Neoplasm Metastasis 12%
  • Proton Therapy 6%
  1 Scopus citations

• Resistance to mutant KRAS^V12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line

  Muraki, N., Yamada, M., Doki, H., Nakai, R., Komeda, K., Goto, D., Kawabe, N., Matsuoka, K., Matsushima, M., Kawabe, T., Tanaka, I., Morise, M., Shay, J. W., Minna, J. D. & Sato, M., May 1 2022, In: Experimental Cell Research. 414, 1, 113053.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epithelial Cells 100%
  • Cell Line 82%
  • Oncogenes 73%
  • Telomerase 35%
  • Galactosidases 23%
  1 Scopus citations

• Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

  Han, J. H., Kim, Y. K., Kim, H., Lee, J., Oh, M. J., Kim, S. B., Kim, M., Kim, K. H., Yoon, H. J., Lee, M. S., Minna, J. D., White, M. A. & Kim, H. S., Aug 2022, In: Cancer Communications. 42, 8, p. 716-749 34 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acetyl Coenzyme A 100%
  • Snails 93%
  • Acetylation 79%
  • Autophagy 72%
  • Oncogenes 72%
  14 Scopus citations

• Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

  Bartolacci, C., Andreani, C., Vale, G., Berto, S., Melegari, M., Crouch, A. C., Baluya, D. L., Kemble, G., Hodges, K., Starrett, J., Politi, K., Starnes, S. L., Lorenzini, D., Raso, M. G., Solis Soto, L. M., Behrens, C., Kadara, H., Gao, B., Wistuba, I. I., Minna, J. D., & 2 othersMcDonald, J. G. & Scaglioni, P. P., Dec 2022, In: Nature communications. 13, 1, 4327.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ferroptosis 100%
  • fatty acids 83%
  • Lipogenesis 77%
  • lungs 68%
  • cancer 59%
  40 Scopus citations

• Tumor Cells Modulate Macrophage Phenotype in a Novel In Vitro Co-Culture Model of the NSCLC Tumor Microenvironment

  Park, J. V., Chandra, R., Cai, L., Ganguly, D., Li, H., Toombs, J. E., Girard, L., Brekken, R. A. & Minna, J. D., Oct 2022, In: Journal of Thoracic Oncology. 17, 10, p. 1178-1191 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Microenvironment 100%
  • Coculture Techniques 95%
  • Macrophages 67%
  • Phenotype 57%
  • In Vitro Techniques 42%
  8 Scopus citations

• Unbiased peptoid cell screen identifies a peptoid targeting newly appeared cell surface vimentin on tumor transformed early lung cancer cells

  Shukla, S. P., Zhang, H., Fang, B., Minna, J. D. & Gomika Udugamasooriya, D., Mar 15 2022, In: Bioorganic and Medicinal Chemistry. 58, 116673.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peptoids 100%
  • Vimentin 57%
  • Lung Neoplasms 44%
  • Oncogenic 22%
  • Neoplasms 18%
  5 Scopus citations
• 2021

  A call to action: Dismantling racial injustices in preclinical research and clinical care of black patients living with small cell lung cancer

  Thomas, P. L., Madubata, C. J., Aldrich, M. C., Lee, M. M., Owonikoko, T. K., Minna, J. D., Rudin, C. M., Sage, J. & Lovly, C. M., Feb 2021, In: Cancer discovery. 11, 2, p. 240-244 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • African Continental Ancestry Group 88%
  • Patient Care 69%
  • Preliminary Data 9%
  • Carcinogens 8%
  9 Scopus citations

• Altered Regulation of HIF-1α in Naive- and Drug-Resistant EGFR-Mutant NSCLC: Implications for a Vascular Endothelial Growth Factor-Dependent Phenotype

  Nilsson, M. B., Robichaux, J., Herynk, M. H., Cascone, T., Le, X., Elamin, Y., Patel, S., Zhang, F., Xu, L., Hu, L., Diao, L., Shen, L., He, J., Yu, X., Nikolinakos, P., Saintigny, P., Fang, B., Girard, L., Wang, J., Minna, J. D., & 2 othersWistuba, I. I. & Heymach, J. V., Mar 2021, In: Journal of Thoracic Oncology. 16, 3, p. 439-451 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vascular Endothelial Growth Factor A 100%
  • Phenotype 69%
  • Pharmaceutical Preparations 48%
  • Hypoxia 18%
  • Mutation 13%
  32 Scopus citations

• A rational targeted therapy for platinum-resistant small-cell lung cancer

  Drapkin, B. J. & Minna, J. D., Apr 12 2021, In: Cancer Cell. 39, 4, p. 453-456 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • Platinum 94%
  • Topotecan 62%
  • Ataxia 47%
  • Drug Therapy 26%
  4 Scopus citations

• ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer

  Pozo, K., Kollipara, R. K., Kelenis, D. P., Rodarte, K. E., Ullrich, M. S., Zhang, X., Minna, J. D. & Johnson, J. E., Sep 24 2021, In: iScience. 24, 9, 102953.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • Genes 36%
  • Transcription Factors 30%
  • Essential Genes 22%
  • Gene Expression Profiling 10%
  18 Scopus citations

• Assessing consistency across functional screening datasets in cancer cells

  Cai, L., Liu, H., Minna, J. D., Deberardinis, R. J., Xiao, G. & Xie, Y., Dec 1 2021, In: Bioinformatics. 37, 23, p. 4540-4547 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Screening 100%
  • High Throughput Screening 97%
  • Cancer 93%
  • Cells 87%
  • Functional Data 82%
  4 Scopus citations

• Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

  Cai, L., Liu, H., Huang, F., Fujimoto, J., Girard, L., Chen, J., Li, Y., Zhang, Y. A., Deb, D., Stastny, V., Pozo, K., Kuo, C. S., Jia, G., Yang, C., Zou, W., Alomar, A., Huffman, K., Papari-Zareei, M., Yang, L., Drapkin, B., & 10 othersAkbay, E. A., Shames, D. S., Wistuba, I. I., Wang, T., Johnson, J. E., Xiao, G., DeBerardinis, R. J., Minna, J. D., Xie, Y. & Gazdar, A. F., Dec 2021, In: Communications Biology. 4, 1, 314.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • lung neoplasms 100%
  • Neuroendocrine Cells 97%
  • Small Cell Lung Carcinoma 84%
  • lungs 60%
  • gene expression 46%
  38 Scopus citations

• Co-immunoprecipitation and semi-quantitative immunoblotting for the analysis of protein-protein interactions

  Burckhardt, C. J., Minna, J. D. & Danuser, G., Sep 17 2021, In: STAR Protocols. 2, 3, 100644.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunoblotting 100%
  • Immunoprecipitation 98%
  • Protein 41%
  • Proteins 37%
  • Densitometry 30%
  23 Scopus citations

• Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

  The NCI PDXNet Consortium, Dec 1 2021, In: Nature communications. 12, 1, 5086.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenic 100%
  • Heterografts 64%
  • Mutation 60%
  • cancer 50%
  • characterization 39%
  54 Scopus citations

• Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids

  Gong, K., Guo, G., Beckley, N. A., Yang, X., Zhang, Y., Gerber, D. E., Minna, J. D., Burma, S., Zhao, D., Akbay, E. A. & Habib, A. A., Dec 2021, In: Nature communications. 12, 1, 7014.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • glucocorticoids 100%
  • Prednisone 85%
  • Glucocorticoid 71%
  • Glucocorticoids 50%
  • Resistance 34%
  6 Scopus citations

• Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

  PDXNET consortium & EurOPDX consortium, Jan 2021, In: Nature genetics. 53, 1, p. 86-99 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heterografts 100%
  • Neoplasms 35%
  • Neoplasm Genes 8%
  • Oligonucleotide Array Sequence Analysis 7%
  • DNA Sequence Analysis 7%
  105 Scopus citations

• Contemporary lung cancer screening and the promise of blood-based biomarkers

  Von Itzstein, M. S., Gerber, D. E. & Minna, J. D., Jul 1 2021, In: Cancer research. 81, 13, p. 3441-3443 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Early Detection of Cancer 100%
  • Lung Neoplasms 83%
  • Biomarkers 68%
  • Tumor Biomarkers 41%
  • Neoplasm Antibodies 28%
  1 Scopus citations

• Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors

  Zhang, A., Ren, Z., Tseng, K. F., Liu, X., Li, H., Lu, C., Cai, Y., Minna, J. D. & Fu, Y. X., Aug 4 2021, In: Science translational medicine. 13, 605, eabg8693.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytotoxic T-Lymphocytes 100%
  • Regulatory T-Lymphocytes 92%
  • Immunity 75%
  • Tumor Microenvironment 36%
  • Proteins 34%
  37 Scopus citations

• Elevated NSD3 histone methylation activity drives squamous cell lung cancer

  Yuan, G., Flores, N. M., Hausmann, S., Lofgren, S. M., Kharchenko, V., Angulo-Ibanez, M., Sengupta, D., Lu, X., Czaban, I., Azhibek, D., Vicent, S., Fischle, W., Jaremko, M., Fang, B., Wistuba, I. I., Chua, K. F., Roth, J. A., Minna, J. D., Shao, N. Y., Jaremko, Ł., & 2 othersMazur, P. K. & Gozani, O., Feb 18 2021, In: Nature. 590, 7846, p. 504-508 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Squamous Cell Neoplasms 100%
  • Histones 75%
  • Methylation 72%
  • Squamous Cell Carcinoma 67%
  • Lung Neoplasms 63%
  70 Scopus citations

• Estrogen Promotes Resistance to Bevacizumab in Murine Models of NSCLC

  Patel, S. A., Herynk, M. H., Cascone, T., Saigal, B., Nilsson, M. B., Tran, H., Ramachandran, S., Diao, L., Wang, J., Le, X., Minna, J., Wistuba, I. I. & Heymach, J. V., Dec 2021, In: Journal of Thoracic Oncology. 16, 12, p. 2051-2064 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bevacizumab 100%
  • Vascular Endothelial Growth Factor A 77%
  • Estrogens 73%
  • Pericytes 44%
  • Myeloid Cells 36%
  7 Scopus citations

• Evasion of innate immunity contributes to small cell lung cancer progression and metastasis

  Zhu, M., Huang, Y., Bender, M. E., Girard, L., Kollipara, R., Eglenen-Polat, B., Naito, Y., Savage, T. K., Huffman, K. E., Koyama, S., Kumanogoh, A., Minna, J. D., Johnson, J. E. & Akbay, E. A., Apr 2021, In: Cancer research. 81, 7, p. 1813-1826 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • Innate Immunity 83%
  • Neoplasm Metastasis 55%
  • Natural Killer Cells 27%
  • Neuroblastoma 19%
  37 Scopus citations

• Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer

  Huang, F., Huffman, K. E., Wang, Z., Wang, X., Li, K., Cai, F., Yang, C., Cai, L., Shih, T. S., Zacharias, L. G., Chung, A., Yang, Q., Chalishazar, M. D., Ireland, A. S., Stewart, C. A., Cargill, K., Girard, L., Liu, Y., Ni, M., Xu, J., & 8 othersWu, X., Zhu, H., Drapkin, B., Byers, L. A., Oliver, T. G., Gazdar, A. F., Minna, J. D. & DeBerardinis, R. J., Jan 4 2021, In: Journal of Clinical Investigation. 131, 1, e139929.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inosine Monophosphate 100%
  • Small Cell Lung Carcinoma 83%
  • Guanosine Triphosphate 79%
  • Ribosomes 78%
  • Oxidoreductases 68%
  28 Scopus citations

• Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer by Suppressing the HER2/AKT Signaling Pathway

  Zhang, W., Bhagwath, A. S., Ramzan, Z., Williams, T. A., Subramaniyan, I., Edpuganti, V., Kallem, R. R., Dunbar, K. B., Ding, P., Gong, K., Geurkink, S. A., Beg, M. S., Kim, J., Zhang, Q., Habib, A. A., Choi, S. H., Lapsiwala, R., Bhagwath, G., Dowell, J. E., Melton, S. D., & 4 othersJie, C., Putnam, W. C., Pham, T. H. & Wang, D. H., Oct 2021, In: Molecular Cancer Therapeutics. 20, 10, p. 1904-1915 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Itraconazole 100%
  • Esophageal Neoplasms 85%
  • Phosphorylation 28%
  • Heterografts 22%
  • S 6 22%
  13 Scopus citations

• Lentiviral-driven discovery of cancer drug resistance mutations

  Yenerall, P., Kollipara, R. K., Avila, K., Peyton, M., Eide, C. A., Bottomly, D., McWeeney, S. K., Liu, Y., Westover, K. D., Druker, B. J., Minna, J. D. & Kittler, R., Sep 15 2021, In: Cancer research. 81, 18, p. 4685-4695 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Resistance 100%
  • Mutation 61%
  • Imatinib Mesylate 49%
  • Neoplasms 35%
  • Human immunodeficiency virus 1 reverse transcriptase 30%
  5 Scopus citations

• Loss of wild type KRAS in KRAS^MUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors

  Liu, Y., Gao, G. F., Minna, J. D., Williams, N. S. & Westover, K. D., Mar 2021, In: Lung Cancer. 153, p. 73-80 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fatty Acid Synthases 100%
  • Adenocarcinoma of Lung 81%
  • Mortality 38%
  • TVB-3664 26%
  • Loss of Heterozygosity 25%
  8 Scopus citations

• Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2–Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology

  Stewart, C. A., Gay, C. M., Ramkumar, K., Cargill, K. R., Cardnell, R. J., Nilsson, M. B., Heeke, S., Park, E. M., Kundu, S. T., Diao, L., Wang, Q., Shen, L., Xi, Y., Zhang, B., Della Corte, C. M., Fan, Y., Kundu, K., Gao, B., Avila, K., Pickering, C. R., & 8 othersJohnson, F. M., Zhang, J., Kadara, H., Minna, J. D., Gibbons, D. L., Wang, J., Heymach, J. V. & Byers, L. A., Nov 2021, In: Journal of Thoracic Oncology. 16, 11, p. 1821-1839 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Epithelial-Mesenchymal Transition 80%
  • Lung Neoplasms 61%
  • Tight Junctions 29%
  29 Scopus citations