The Center for Human Nutrition

2024

Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

Deja, S., Fletcher, J., Kim, C-W., Kucejova, B., Fu, X., Mizerska, M., Villegas, M., Pudelko-Malik, N., Browder, N., Inigo-Vollmer, M., Menezes, C. J., Mishra, P., Berglund, E. D., Browning, J. D., Thyfault, J. P., Young, J. D., Horton, J. D. & Burgess, S. C., 2024, (Accepted/In press) In: Cell Metabolism.

Research output: Contribution to journal › Article › peer-review

Open Access

Impact of Pretreatment Weight Loss on Radiotherapy Utilization and Clinical Outcomes in Non–Small Cell Lung Cancer

Alvarez, C. M., Aliru, M., Gannavarapu, B. S., Song, T., Gilmore, L. A., Olaechea, S., Gomez, D. R., Ahn, C., Infante, R. E. & Iyengar, P., Feb 1 2024, In: American Journal of Clinical Oncology: Cancer Clinical Trials. 47, 2, p. 49-55 7 p.

Research output: Contribution to journal › Article › peer-review

2023

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

Madenspacher, J. H., Morrell, E. D., McDonald, J. G., Thompson, B. M., Li, Y., Birukov, K. G., Birukova, A. A., Stapleton, R. D., Alejo, A., Karmaus, P. W., Meacham, J. M., Rai, P., Mikacenic, C., Wurfel, M. M. & Fessler, M. B., Apr 10 2023, In: JCI Insight. 8, 7, e155448.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

A Concerted Mechanism Involving ACAT and SREBPs By which Oxysterols Deplete Accessible Cholesterol To Restrict Microbial Infection

Heisler, D. B., Johnson, K. A., Ma, D., Ohlson, M. B., Zhang, L., Tran, M., Corley, C. D., Abrams, M. E., McDonald, J. G., Schoggins, J. W., Alto, N. M. & Radhakrishnan, A., Jan 2023, In: eLife. 12, e83534.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Cutaneous Hormone Production Is Distinct between Anatomical Sites and between Males and Females

Pineider, J., Eckert, K. M., McDonald, J. G. & Harris-Tryon, T., Apr 2023, In: Journal of Investigative Dermatology. 143, 4, p. 596-601 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice

Yiew, N. K. H., Deja, S., Ferguson, D., Cho, K., Jarasvaraparn, C., Jacome-Sosa, M., Lutkewitte, A. J., Mukherjee, S., Fu, X., Singer, J. M., Patti, G. J., Burgess, S. C. & Finck, B. N., Nov 17 2023, In: iScience. 26, 11, 108196.

Research output: Contribution to journal › Article › peer-review

Open Access

Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice

Fessler, M. B., Madenspacher, J. H., Baker, P. J., Hilligan, K. L., Bohrer, A. C., Castro, E., Meacham, J., Chen, S. H., Johnson, R. F., McDonald, J. G., Martin, N. P., Tucker, C. J., Mahapatra, D., Cesta, M. & Mayer-Barber, K. D., Dec 2023, In: American journal of respiratory cell and molecular biology. 69, 6, p. 638-648 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization

Onodera, T., Wang, M. Y., Rutkowski, J. M., Deja, S., Chen, S., Balzer, M. S., Kim, D. S., Sun, X., An, Y. A., Field, B. C., Lee, C., Matsuo, E. I., Mizerska, M., Sanjana, I., Fujiwara, N., Kusminski, C. M., Gordillo, R., Gautron, L., Marciano, D. K., Hu, M. C., & 4 othersBurgess, S. C., Susztak, K., Moe, O. W. & Scherer, P. E., Dec 2023, In: Nature communications. 14, 1, 6531.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

Parida, P. K., Marquez-Palencia, M., Ghosh, S., Khandelwal, N., Kim, K., Nair, V., Liu, X. Z., Vu, H. S., Zacharias, L. G., Gonzalez-Ericsson, P. I., Sanders, M. E., Mobley, B. C., McDonald, J. G., Lemoff, A., Peng, Y., Lewis, C., Vale, G., Halberg, N., Arteaga, C. L., Hanker, A. B., & 2 othersDeBerardinis, R. J. & Malladi, S., Jun 2023, In: Nature Cancer. 4, 6, p. 893-907 15 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

Rome, F. I., Shobert, G. L., Voigt, W. C., Stagg, D. B., Puchalska, P., Burgess, S. C., Crawford, P. A. & Hughey, C. C., Jan 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 324, 1, p. E9-E23

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling

Canfrán-Duque, A., Rotllan, N., Zhang, X., Andrés-Blasco, I., Thompson, B. M., Sun, J., Price, N. L., Fernández-Fuertes, M., Fowler, J. W., Gómez-Coronado, D., Sessa, W. C., Giannarelli, C., Schneider, R. J., Tellides, G., McDonald, J. G., Fernández-Hernando, C. & Suárez, Y., Jan 31 2023, In: Circulation. 147, 5, p. 388-408 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Myocardial steatosis impairs left ventricular diastolic–systolic coupling in healthy humans

Oneglia, A. P., Szczepaniak, L. S., Jaffery, M. F., Cipher, D. J., McDonald, J. G., Haykowsky, M. J., Moreau, K. L., Clegg, D. J., Zaha, V. & Nelson, M. D., Apr 15 2023, In: Journal of Physiology. 601, 8, p. 1371-1382 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver

Fu, X., Fletcher, J. A., Deja, S., Inigo-Vollmer, M., Burgess, S. C. & Browning, J. D., May 1 2023, In: Journal of Clinical Investigation. 133, 9, e167442.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Race, Ethnicity, and Socioeconomic Factors as Determinants of Cachexia Incidence and Outcomes in a Retrospective Cohort of Patients with Gastrointestinal Tract Cancer

Olaechea, S., Sarver, B., Liu, A., Gilmore, L. A., Alvarez, C., Iyengar, P. & Infante, R., Jul 1 2023, In: JCO Oncology Practice. 19, 7, p. 493-500 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Racial, Ethnic, and Socioeconomic Characteristics Independently Predict for Cachexia Risk and Associated Survival Outcomes in Stage IV NSCLC: A Brief Report

Olaechea, S., Liu, A., Sarver, B., Gilmore, L. A., Alvarez, C., Yazdanbakhsh, K., Infante, R. & Iyengar, P., Apr 2023, In: JTO Clinical and Research Reports. 4, 4, 100496.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue

Agarwal, A. K., Tunison, K., Vale, G., McDonald, J. G., Li, X., Scherer, P. E., Horton, J. D. & Garg, A., Oct 20 2023, In: iScience. 26, 10, 107806.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production

Nguyen, T. P., Wang, W., Sternisha, A. C., Corley, C. D., Wang, H. Y. L., Wang, X., Ortiz, F., Lim, S. K., Abdullah, K. G., Parada, L. F., Williams, N. S., McBrayer, S. K., McDonald, J. G., De Brabander, J. K. & Nijhawan, D., Feb 16 2023, In: Cell Chemical Biology. 30, 2, p. 214-229.e18

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

Chen, H., Ahmed, S., Zhao, H., Elghobashi-Meinhardt, N., Dai, Y., Kim, J. H., McDonald, J. G., Li, X. & Lee, C. H., Jun 8 2023, In: Cell. 186, 12, p. 2644-2655.e16

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Iyengar, P., Gandhi, A. Y., Granados, J., Guo, T., Gupta, A., Yu, J., Llano, E. M., Zhang, F., Gao, A., Kandathil, A., Williams, D., Gao, B., Girard, L., Malladi, V. S., Shelton, J. M., Evers, B. M., Hannan, R., Ahn, C., Minna, J. D. & Infante, R. E., 2023, In: JCI Insight. 8, 8, e165419.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Wang, C., Wang, B., Pandey, T., Long, Y., Zhang, J., Oh, F., Sima, J., Guo, R., Liu, Y., Zhang, C., Mukherjee, S., Bassik, M., Lin, W., Deng, H., Vale, G., McDonald, J. G., Shen, K. & Ma, D. K., Dec 2022, In: Nature communications. 13, 1, 6805.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

A preponderance of gastrointestinal cancer patients transition into cachexia syndrome

Gilmore, L. A., Olaechea, S., Gilmore, B. W., Gannavarapu, B. S., Alvarez, C. M., Ahn, C., Iyengar, P. & Infante, R. E., Dec 2022, In: Journal of Cachexia, Sarcopenia and Muscle. 13, 6, p. 2920-2931 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Association of demographic and health characteristics with circulating oxysterol concentrations

Passarelli, M. N., McDonald, J. G., Thompson, B. M., Arega, E. A., Palys, T. J., Rees, J. R., Barry, E. L. & Baron, J. A., May 1 2022, In: Journal of Clinical Lipidology. 16, 3, p. 345-355 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Association of Vaginal Progesterone Treatment With Prevention of Recurrent Preterm Birth

Nelson, D. B., Lafferty, A., Venkatraman, C., McDonald, J. G., Eckert, K. M., McIntire, D. D. & Spong, C. Y., Oct 3 2022, In: JAMA Network Open. 5, 10, p. e2237600

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Associations of Prior Chronic Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Glucocorticoids With Cachexia Incidence and Survival

Olaechea, S., Gilmore, A., Alvarez, C., Gannavarapu, B. S., Infante, R. & Iyengar, P., Jun 7 2022, In: Frontiers in Oncology. 12, 922418.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Cachexia is Prevalent in Patients With Hepatocellular Carcinoma and Associated With Worse Prognosis

Rich, N. E., Phen, S., Desai, N., Mittal, S., Yopp, A. C., Yang, J. D., Marrero, J. A., Iyengar, P., Infante, R. E. & Singal, A. G., May 2022, In: Clinical Gastroenterology and Hepatology. 20, 5, p. e1157-e1169

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia

Gandhi, A. Y., Yu, J., Gupta, A., Guo, T., Iyengar, P. & Infante, R. E., Jun 15 2022, In: Frontiers in Oncology. 12, 841758.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone

Cenik, B., Palka, J. M., Thompson, B. M., McDonald, J. G., Tamminga, C. A., Cenik, C. & Brown, E. S., Dec 2022, In: Translational psychiatry. 12, 1, 139.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids

Cui, S., Simmons, G., Vale, G., Deng, Y., Kim, J., Kim, H., Zhang, R., McDonald, J. G. & Ye, J., Apr 26 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 2107189119.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

Luo, F., Smagris, E., Martin, S. A., Vale, G., McDonald, J. G., Fletcher, J. A., Burgess, S. C., Hobbs, H. H. & Cohen, J. C., Jan 2022, In: CMGH. 13, 3, p. 879-899 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis

Rahim, M., Ragavan, M., Deja, S., Merritt, M. E., Burgess, S. C. & Young, J. D., Jan 2022, In: Metabolic Engineering. 69, p. 275-285 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol

Trinh, M. N., Brown, M. S., Seemann, J., Vale, G., McDonald, J. G., Goldstein, J. L. & Lu, F., Jan 11 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 2, e2120411119.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Intracellular lipid surveillance by small G protein geranylgeranylation

Watterson, A., Tatge, L., Wajahat, N., Arneaud, S. L. B., Solano Fonseca, R., Beheshti, S. T., Metang, P., Mihelakis, M., Zuurbier, K. R., Corley, C. D., Dehghan, I., McDonald, J. G. & Douglas, P. M., May 26 2022, In: Nature. 605, 7911, p. 736-740 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization

Watterson, A., Arneaud, S. L. B., Wajahat, N., Wall, J. M., Tatge, L., Beheshti, S. T., Mihelakis, M., Cheatwood, N. Y., McClendon, J., Ghorashi, A., Dehghan, I., Corley, C. D., McDonald, J. G. & Douglas, P. M., Oct 18 2022, In: Cell Reports. 41, 3, 111493.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity

Zhang, Z., Xun, Y., Rong, S., Yan, L., SoRelle, J. A., Li, X., Tang, M., Keller, K., Ludwig, S., Moresco, E. M. Y. & Beutler, B., Dec 2022, In: Nature communications. 13, 1, 4136.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Prevalence and significance of risk enhancing biomarkers in the United States population at intermediate risk for atherosclerotic disease

Vega, G. L., Wang, J. & Grundy, S. M., Jan 1 2022, In: Journal of Clinical Lipidology. 16, 1, p. 66-74 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Primary Tumor Fluorine‐18 Fluorodeoxydglucose (¹⁸F‐FDG) Is Associated With Cancer-Associated Weight Loss in Non-Small Cell Lung Cancer (NSCLC) and Portends Worse Survival

Olaechea, S., Gannavarapu, B. S., Alvarez, C., Gilmore, A., Sarver, B., Xie, D., Infante, R. & Iyengar, P., Jun 24 2022, In: Frontiers in Oncology. 12, 900712.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Repeated trans-arterial treatments of LDL-DHA nanoparticles induce multiple pathways of tumor cell death in hepatocellular carcinoma bearing rats

Wang, Y., Li, J., Vale, G. D. D., Chaudhary, J., Anwar, A., McDonald, J. G., Qin, T., Zhang, H. & Corbin, I. R., Nov 24 2022, In: Frontiers in Oncology. 12, 1052221.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

Martino, M. R., Gutiérrez-Aguilar, M., Yiew, N. K. H., Lutkewitte, A. J., Singer, J. M., McCommis, K. S., Ferguson, D., Liss, K. H. H., Yoshino, J., Renkemeyer, M. K., Smith, G. I., Cho, K., Fletcher, J. A., Klein, S., Patti, G. J., Burgess, S. C. & Finck, B. N., Apr 26 2022, In: Cell Reports. 39, 4, 110733.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Bartolacci, C., Andreani, C., Vale, G., Berto, S., Melegari, M., Crouch, A. C., Baluya, D. L., Kemble, G., Hodges, K., Starrett, J., Politi, K., Starnes, S. L., Lorenzini, D., Raso, M. G., Solis Soto, L. M., Behrens, C., Kadara, H., Gao, B., Wistuba, I. I., Minna, J. D., & 2 othersMcDonald, J. G. & Scaglioni, P. P., Dec 2022, In: Nature communications. 13, 1, 4327.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Transcriptional Integration of Distinct Microbial and Nutritional Signals by the Small Intestinal Epithelium

Lickwar, C. R., Davison, J. M., Kelly, C., Mercado, G. P., Wen, J., Davis, B. R., Tillman, M. C., Semova, I., Andres, S. F., Vale, G., McDonald, J. G. & Rawls, J. F., Jan 2022, In: CMGH. 14, 2, p. 465-493 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells

Luo, M., Bao, L., Chen, Y., Xue, Y., Wang, Y., Zhang, B., Wang, C., Corley, C. D., McDonald, J. G., Kumar, A., Xing, C., Fang, Y., Nelson, E. R., Wang, J. E., Wang, Y. & Luo, W., 2022, In: Science Advances. 8, 28, abn5295.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

Assessing the safety of transarterial locoregional delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat liver

Li, J., Canseco, D., Wang, Y., Vale, G., Chaudhary, J., Anwar, A., Baniasadi, H., Williams, N. S., Gopal, P., Sutphin, P. D., McDonald, J. G., Putnam, W. C. & Corbin, I. R., Jan 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 158, p. 273-283 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Circulating 27-hydroxycholesterol and risk of colorectal adenomas and serrated polyps

Passarelli, M. N., Thompson, B. M., McDonald, J. G., Snover, D. C., Palys, T. J., Rees, J. R., Barry, E. L. & Baron, J. A., 2021, In: Cancer Prevention Research. 14, 4, p. 479-488 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Decreased caveolae in AGPAT2 lacking adipocytes is independent of changes in cholesterol or sphingolipid levels: A whole cell and plasma membrane lipidomic analysis of adipogenesis

González-Hódar, L., McDonald, J. G., Vale, G., Thompson, B. M., Figueroa, A. M., Tapia, P. J., Robledo, F., Agarwal, A. K., Garg, A., Horton, J. D. & Cortés, V., Sep 1 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 9, 166167.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis

Zhang, X., McDonald, J. G., Aryal, B., Canfran-Duque, A., Goldberg, E. L., Araldi, E., Ding, W., Fan, Y., Thompson, B. M., Singh, A. K., Li, Q., Tellides, G., Ordovas-Montanes, J., Garcia Milian, R., Dixit, V. D., Ikonen, E., Suarez, Y. & Fernandez-Hernando, C., Nov 23 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2107682118.

Research output: Contribution to journal › Article › peer-review

Open Access