Research output per year
Research output per year
- 1 - 50 out of 545 results
Search results
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2024
Severely polarized extracellular acidity around tumour cells
Feng, Q., Bennett, Z., Grichuk, A., Pantoja, R., Huang, T., Faubert, B., Huang, G., Chen, M., DeBerardinis, R. J., Sumer, B. D. & Gao, J., 2024, (Accepted/In press) In: Nature Biomedical Engineering.Research output: Contribution to journal › Article › peer-review
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STING licensing of type I dendritic cells potentiates antitumor immunity
Wang, J., Li, S., Wang, M., Wang, X., Chen, S., Sun, Z., Ren, X., Huang, G., Sumer, B. D., Yan, N., Fu, Y. X. & Gao, J., Feb 2024, In: Science Immunology. 9, 92, eadj3945.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
Prabhakar, A. T., James, C. D., Fontan, C. T., Otoa, R., Wang, X., Bristol, M. L., Yeager, C., Hill, R. D., Dubey, A., Wu, S. Y., Chiang, C. M. & Morgan, I. M., Oct 2023, In: Journal of virology. 97, 10Research output: Contribution to journal › Article › peer-review
Open Access -
Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping
Yang, H., Sui, P., Guo, Y., Chen, S., Maloof, M. E., Ge, G., Nihozeko, F., Delma, C. R., Zhu, G., Zhang, P., Ye, Z., Medina, E. A., Ayad, N. G., Mesa, R., Nimer, S. D., Chiang, C. M., Xu, M., Chen, Y. & Yang, F. C., Oct 9 2023, In: EMBO Reports. 24, 10, e57032.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden
Zhu, M., Kim, J., Deng, Q., Ricciuti, B., Alessi, J. V., Eglenen-Polat, B., Bender, M. E., Huang, H. C., Kowash, R. R., Cuevas, I., Bennett, Z. T., Gao, J., Minna, J. D., Castrillon, D. H., Awad, M. M., Xu, L. & Akbay, E. A., Oct 9 2023, In: Cancer Cell. 41, 10, p. 1731-1748.e8Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation
Guan, Q., Chen, Z., Yu, F., Liu, L., Huang, Y., Wei, G., Chiang, C. M., Wong, J. & Li, J., Sep 2023, In: Science China Life Sciences. 66, 9, p. 2167-2184 18 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association
Cao, J., Shi, M., Zhu, L., Li, X., Li, A., Wu, S. Y., Chiang, C. M. & Zhang, Y., Oct 2023, In: Journal of virology. 97, 10Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2022
Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping and Protein Isoform Detection
Lewis, M. P., Wu, S. Y. & Chiang, C. M., Apr 5 2022, In: Bio-protocol. 12, 7, e4374.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site
Liu, Z., Li, Y., Chen, H., Lai, H. T., Wang, P., Wu, S. Y., Wold, E. A., Leonard, P. G., Joseph, S., Hu, H., Chiang, C. M., Brasier, A. R., Tian, B. & Zhou, J., Feb 10 2022, In: Journal of Medicinal Chemistry. 65, 3, p. 2388-2408 21 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation
Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., Hatanpaa, K. J., Garzon-Muvdi, T., Koduru, P., Nayab, A., Jenks, J., Sathe, A. A., Liu, Y., Xing, C., Wu, S. Y., Chiang, C. M., Mukherjee, B., Burma, S., Wohlfeld, B., Patel, T., & 10 others, Aug 2022, In: Nature cell biology. 24, 8, p. 1291-1305 15 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy
Jiang, X., Wang, J., Zheng, X., Liu, Z., Zhang, X., Li, Y., Wilhelm, J., Cao, J., Huang, G., Zhang, J., Sumer, B., Lea, J., Lu, Z., Gao, J. & Luo, M., May 27 2022, In: Journal for ImmunoTherapy of Cancer. 10, 5, e003960.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
Feng, Q., Liu, Z., Yu, X., Huang, T., Chen, J., Wang, J., Wilhelm, J., Li, S., Song, J., Li, W., Sun, Z., Sumer, B. D., Li, B., Fu, Y. X. & Gao, J., Dec 2022, In: Nature communications. 13, 1, 4981.Research output: Contribution to journal › Article › peer-review
Open Access87 Scopus citations -
Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition
Udden, S. N., Wang, Q., Kumar, S., Malladi, V. S., Wu, S. Y., Wei, S., Posner, B. A., Geboers, S., Williams, N. S., Liu, Y., Sharma, J. K., Mani, R. S., Malladi, S., Parra, K., Hofstad, M., Raj, G. V., Larios, J. M., Jagsi, R., Wicha, M. S., Park, B. H., & 4 others, Sep 8 2022, In: JCI Insight. 7, 17, e151851.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2021
Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine
Wilhelm, J., Quiñones-Pérez, M., Wang, J., Wang, X., Basava, V. S. & Gao, J., Jan 10 2021, In: Journal of Controlled Release. 329, p. 353-360 8 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
A Standardized Framework for Fluorescence-Guided Margin Assessment for Head and Neck Cancer Using a Tumor Acidosis Sensitive Optical Imaging Agent
Steinkamp, P. J., Voskuil, F. J., van der Vegt, B., Doff, J. J., Schepman, K. P., de Visscher, S. A. H. J., Kelder, W., Jayalakshmi, Y., Gao, J., Sumer, B. D., van Dam, G. M. & Witjes, M. J. H., Dec 2021, In: Molecular Imaging and Biology. 23, 6, p. 809-817 9 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Blood-based biomarkers of human papillomavirus–associated cancers: A systematic review and meta-analysis
Balachandra, S., Kusin, S. B., Lee, R., Blackwell, J. M., Tiro, J. A., Cowell, L. G., Chiang, C. M., Wu, S. Y., Varma, S., Rivera, E. L., Mayo, H. G., Ding, L., Sumer, B. D., Lea, J. S., Bagrodia, A., Farkas, L. M., Wang, R., Fakhry, C., Dahlstrom, K. R., Sturgis, E. M., & 1 others, Mar 15 2021, In: Cancer. 127, 6, p. 850-864 15 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination
Jung, H., Chen, J., Hu, X., Sun, H., Wu, S. Y., Chiang, C. M., Kemper, B., Chen, L. F. & Kemper, J. K., Jan 11 2021, In: JCI Insight. 6, 1, e141640.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy
Zhang, J., Tang, P., Zou, L., Zhang, J., Chen, J., Yang, C., He, G., Liu, B., Liu, J., Chiang, C. M., Wang, G., Ye, T. & Ouyang, L., Dec 23 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 18025-18053 29 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Expression of phosphorylated brd4 is markedly associated with the activation status of the pp2a pathway and shows astrong prognostic value in triple negative breast cancer patients
Sanz-álvarez, M., Cristóbal, I., Luque, M., Santos, A., Zazo, S., Madoz-Gúrpide, J., Caramés, C., Chiang, C. M., García-Foncillas, J., Eroles, P., Albanell, J. & Rojo, F., Mar 2 2021, In: Cancers. 13, 6, p. 1-11 11 p., 1246.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Factors Associated with Lymph Node Count in Mucosal Squamous Cell Carcinoma Neck Dissection
Bhalli, H., Chen, S., Day, A., Tillman, B., Gordin, E., Truelson, J., Sher, D., Myers, L., Gao, J. & Sumer, B. D., Jul 2021, In: Laryngoscope. 131, 7, p. 1516-1521 6 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome
Kim, S. K., Liu, X., Park, J., Um, D., Kilaru, G., Chiang, C. M., Kang, M., Huber, K. M., Kang, K. & Kim, T. K., May 2021, In: Science Advances. 7, 21, eabf7346.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Prolonged activation of innate immune pathways by a polyvalent STING agonist
Li, S., Luo, M., Wang, Z., Feng, Q., Wilhelm, J., Wang, X., Li, W., Wang, J., Cholka, A., Fu, Y. X., Sumer, B. D., Yu, H. & Gao, J., May 2021, In: Nature Biomedical Engineering. 5, 5, p. 455-466 12 p.Research output: Contribution to journal › Article › peer-review
Open Access143 Scopus citations -
Tumor-Targeted Inhibition of Monocarboxylate Transporter 1 Improves T-Cell Immunotherapy of Solid Tumors
Huang, T., Feng, Q., Wang, Z., Li, W., Sun, Z., Wilhelm, J., Huang, G., Vo, T., Sumer, B. D. & Gao, J., Feb 17 2021, In: Advanced Healthcare Materials. 10, 4, 2000549.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
2020
Detection of lymph node metastases by ultra-pH-sensitive polymeric nanoparticles
Bennett, Z. T., Feng, Q., Bishop, J. A., Huang, G., Sumer, B. D. & Gao, J., 2020, In: Theranostics. 10, 7, p. 3340-3350 11 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer
Gong, K., Guo, G., Panchani, N., Bender, M. E., Gerber, D. E., Minna, J. D., Fattah, F., Gao, B., Peyton, M., Kernstine, K., Mukherjee, B., Burma, S., Chiang, C. M., Zhang, S., Amod Sathe, A., Xing, C., Dao, K. H., Zhao, D., Akbay, E. A. & Habib, A. A., Apr 1 2020, In: Nature Cancer. 1, 4, p. 394-409 16 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver
Dubois, V., Gheeraert, C., Vankrunkelsven, W., Dubois-Chevalier, J., Dehondt, H., Bobowski-Gerard, M., Vinod, M., Zummo, F. P., Güiza, F., Ploton, M., Dorchies, E., Pineau, L., Boulinguiez, A., Vallez, E., Woitrain, E., Baugé, E., Lalloyer, F., Duhem, C., Rabhi, N., van Kesteren, R. E., & 10 others, May 1 2020, In: Molecular Systems Biology. 16, 5, e9156.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery
the SHINE study group, Dec 1 2020, In: Nature communications. 11, 1, 3257.Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
Lu, L., Chen, Z., Lin, X., Tian, L., Su, Q., An, P., Li, W., Wu, Y., Du, J., Shan, H., Chiang, C. M. & Wang, H., Jan 1 2020, In: Cell Death and Differentiation. 27, 1, p. 255-268 14 p.Research output: Contribution to journal › Article › peer-review
Open Access67 Scopus citations -
KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs
Bacon, C. W., Challa, A., Hyder, U., Shukla, A., Borkar, A. N., Bayo, J., Liu, J., Wu, S. Y., Chiang, C. M., Kutateladze, T. G. & D'Orso, I., Jun 18 2020, In: Molecular cell. 78, 6, p. 1133-1151.e14Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming
Chen, Z., Wu, L., Zhou, J., Lin, X., Peng, Y., Ge, L., Chiang, C. M., Huang, H., Wang, H. & He, W., 2020, In: Theranostics. 10, 8, p. 3382-3396 15 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles
Li, S., Bennett, Z. T., Sumer, B. D. & Gao, J., Nov 17 2020, In: Accounts of Chemical Research. 53, 11, p. 2546-2557 12 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Opposing Functions of BRD4 Isoforms in Breast Cancer
Wu, S. Y., Lee, C. F., Lai, H. T., Yu, C. T., Lee, J. E., Zuo, H., Tsai, S. Y., Tsai, M. J., Ge, K., Wan, Y. & Chiang, C. M., Jun 18 2020, In: Molecular cell. 78, 6, p. 1114-1132.e10Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition
Wang, L. T., Liu, K. Y., Jeng, W. Y., Chiang, C. M., Chai, C. Y., Chiou, S. S., Huang, M. S., Yokoyama, K. K., Wang, S. N., Huang, S. K. & Hsu, S. H., Feb 5 2020, In: EMBO Reports. 21, 2, e48795.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive 64Cu-labelled polymers
Huang, G., Zhao, T., Wang, C., Nham, K., Xiong, Y., Gao, X., Wang, Y., Hao, G., Ge, W. P., Sun, X., Sumer, B. D. & Gao, J., Mar 1 2020, In: Nature Biomedical Engineering. 4, 3, p. 314-324 11 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window
Wang, X., Wilhelm, J., Li, W., Li, S., Wang, Z., Huang, G., Wang, J., Tang, H., Khorsandi, S., Sun, Z., Evers, B. & Gao, J., Dec 2020, In: Nature communications. 11, 1, 5828.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
Li, J., Chen, Z., Chen, F., Xie, G., Ling, Y., Peng, Y., Lin, Y., Luo, N., Chiang, C. M. & Wang, H., 2020, In: Nucleic acids research. 48, 10, p. 5684-5694 11 p.Research output: Contribution to journal › Article › peer-review
Open Access131 Scopus citations -
Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer
Tsai, L. H., Hsu, K. W., Chiang, C. M., Yang, H. J., Liu, Y. H., Yang, S. F., Peng, P. H., Cheng, W. C. & Wu, H. H., Dec 1 2020, In: Scientific reports. 10, 1, 17817.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2019
Combinatorial therapy of zinc metallochaperones with mutant p53 reactivation and diminished copper binding
Zaman, S., Yu, X., Bencivenga, A. F., Blanden, A. R., Liu, Y., Withers, T., Na, B., Blayney, A. J., Gilleran, J., Boothman, D. A., Loh, S. N., Kimball, S. D. & Carpizo, D. R., 2019, In: Molecular Cancer Therapeutics. 18, 8, p. 1355-1365 11 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers
Motea, E. A., Huang, X., Singh, N., Kilgore, J. A., Williams, N. S., Xie, X. J., Gerber, D. E., Beg, M. S., Bey, E. A. & Boothman, D. A., Apr 15 2019, In: Clinical Cancer Research. 25, 8, p. 2601-2609 9 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy
Luo, M., Liu, Z., Zhang, X., Han, C., Samandi, L. Z., Dong, C., Sumer, B. D., Lea, J., Fu, Y. X. & Gao, J., Apr 28 2019, In: Journal of Controlled Release. 300, p. 154-160 7 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity
Kim, J. J., Lee, S. Y., Gong, F., Battenhouse, A. M., Boutz, D. R., Bashyal, A., Refvik, S. T., Chiang, C. M., Xhemalce, B., Paull, T. T., Brodbelt, J. S., Marcotte, E. M. & Miller, K. M., Dec 1 2019, In: Genes and Development. 33, 23-24, p. 1751-1774 24 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations -
Targeting the oncogene kras mutant pancreatic cancer by synergistic blocking of lysosomal acidification and rapid drug release
Kong, C., Li, Y., Liu, Z., Ye, J., Wang, Z., Zhang, L., Kong, W., Liu, H., Liu, C., Pang, H., Hu, Z., Gao, J. & Qian, F., Apr 23 2019, In: ACS Nano. 13, 4, p. 4049-4063 15 p.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
Penas, C., Maloof, M. E., Stathias, V., Long, J., Tan, S. K., Mier, J., Fang, Y., Valdes, C., Rodriguez-Blanco, J., Chiang, C. M., Robbins, D. J., Liebl, D. J., Lee, J. K., Hatten, M. E., Clarke, J. & Ayad, N. G., Dec 1 2019, In: Nature communications. 10, 1, 3028.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial–mesenchymal transition and metastasis in liver cancer
Wang, L. T., Wang, S. N., Chiou, S. S., Liu, K. Y., Chai, C. Y., Chiang, C. M., Huang, S. K., Yokoyama, K. K. & Hsu, S. H., Jan 24 2019, In: Oncogene. 38, 4, p. 518-532 15 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus
Zhao, J., Lee, E. E., Kim, J., Yang, R., Chamseddin, B., Ni, C., Gusho, E., Xie, Y., Chiang, C. M., Buszczak, M., Zhan, X., Laimins, L. & Wang, R. C., Dec 1 2019, In: Nature communications. 10, 1, 2300.Research output: Contribution to journal › Article › peer-review
Open Access223 Scopus citations -
Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles
Feng, Q., Wilhelm, J. & Gao, J., Jun 18 2019, In: Accounts of Chemical Research. 52, 6, p. 1485-1495 11 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
2018
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice
Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer
Li, X., Baek, G. H., Ramanand, S. G., Sharp, A., Gao, Y., Yuan, W., Welti, J., Rodrigues, D. N., Dolling, D., Figueiredo, I., Sumanasuriya, S., Crespo, M., Aslam, A., Li, R., Yin, Y., Mukherjee, B., Kanchwala, M., Hughes, A. M., Halsey, W. S., Chiang, C. M., & 5 others, Jan 16 2018, In: Cell Reports. 22, 3, p. 796-808 13 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids for Nucleic Acid Delivery
Miller, J. B., Kos, P., Tieu, V., Zhou, K. & Siegwart, D. J., Jan 24 2018, In: ACS Applied Materials and Interfaces. 10, 3, p. 2302-2311 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Following anticancer drug activity in cell lysates with DNA devices
Kahanda, D., Singh, N., Boothman, D. A. & Slinker, J. D., Nov 15 2018, In: Biosensors and Bioelectronics. 119, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations