Research output per year
Research output per year
- 1 - 50 out of 86 results
Search results
-
1982
Virus-induced alterations in homeostasis: Alterations in differentiated functions of infected cells in vivo
Oldstone, M. B. A., Sinha, Y. N., Blount, P., Tishon, A., Rodriguez, M., Von Wedel, R. & Lampert, P. W., 1982, In: Science. 218, 4577, p. 1125-1127 3 p.Research output: Contribution to journal › Article › peer-review
151 Scopus citations -
1984
Analysis of persistent virus infections by in situ hybridization to whole-mouse sections
Southern, P. J., Blount, P. & Oldstone, M. B. A., 1984, In: Nature. 312, 5994, p. 555-558 4 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
1985
Perturbation of differentiated functions during viral infectionin Vivo I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency
Oldstone, M. B. A., Ahmed, R., Buchmeier, M. J., Blount, P. & Tishon, A., Apr 15 1985, In: Virology. 142, 1, p. 158-174 17 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
1986
Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system
Oldstone, M. B. A., Blount, P., Southern, P. J. & Lampert, P. W., 1986, In: Nature. 321, 6067, p. 239-243 5 p.Research output: Contribution to journal › Article › peer-review
208 Scopus citations -
Dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus
Valsamakis, V., Southern, P., Blount, P., Ahmed, R., Buchmeier, M. J. & Oldstone, M. B. A., May 1986, In: Medical Microbiology and Immunology. 175, 2-3, p. 97-99 3 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Dissecting the molecular anatomy of the nervous system: Analysis of RNA and protein expression in whole body sections of laboratory animals
Blount, P., Elder, J., Ian Lipkin, W., Southern, P. J., Buchmeier, M. J. & Oldstone, M. B. A., Sep 24 1986, In: Brain Research. 382, 2, p. 257-265 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
1988
Native folding of an acetylcholine receptor α subunit expressed in the absence of other receptor subunits
Blount, P. & Merlie, J. P., 1988, In: Journal of Biological Chemistry. 263, 2, p. 1072-1080 9 p.Research output: Contribution to journal › Article › peer-review
97 Scopus citations -
1989
Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor
Blount, P. & Merlie, J. P., Sep 1989, In: Neuron. 3, 3, p. 349-357 9 p.Research output: Contribution to journal › Article › peer-review
264 Scopus citations -
1990
Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts
Blount, P., Smith, M. M. & Merlie, J. P., Dec 1990, In: Journal of Cell Biology. 111, 6 PART 1, p. 2601-2611 11 p.Research output: Contribution to journal › Article › peer-review
93 Scopus citations -
Mutational analysis of muscle nicotinic acetylcholine receptor subunit assembly
Blount, P. & Merlie, J. P., Dec 1990, In: Journal of Cell Biology. 111, 6 PART 1, p. 2613-2622 10 p.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
1991
ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kildalton protein
Phillips, W. D., Kopta, C., Blount, P., Gardner, P. D., Steinbach, J. H. & Merlie, J. P., Feb 1 1991, In: Science. 251, 4993, p. 568-570 3 p.Research output: Contribution to journal › Article › peer-review
201 Scopus citations -
BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor
Blount, P. & Merlie, J. P., Jun 1991, In: Journal of Cell Biology. 113, 5, p. 1125-1132 8 p.Research output: Contribution to journal › Article › peer-review
95 Scopus citations -
Characterization of an adult muscle acetylcholine receptor subunit by expression in fibroblasts
Blount, P. & Merlie, J. P., 1991, In: Journal of Biological Chemistry. 266, 22, p. 14692-14696 5 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
1992
Ligand Binding Kinetics of Substance P and Neurokinin A Receptors Stably Expressed in Chinese Hamster Ovary Cells and Evidence for Differential Stimulation of Inositol 1,4,5‐Trisphosphate and Cyclic AMP Second Messenger Responses
Takeda, Y., Blount, P., Sachais, B. S., Hershey, A. D., Raddatz, R. & Krause, J. E., Aug 1992, In: Journal of Neurochemistry. 59, 2, p. 740-745 6 p.Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
1993
Functional nonequivalence of structurally homologous domains of neurokinin-1 and neurokinin-2 type tachykinin receptors
Blount, P. & Krause, J. E., Aug 5 1993, In: Journal of Biological Chemistry. 268, 22, p. 16388-16395 8 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
Structure, expression and second messenger-mediated regulation of the human and rat substance P receptors and their genes
Krause, J. E., Bu, J. Y., Takeda, Y., Blount, P., Raddatz, R., Sachais, B. S., Chou, K. B., Takeda, J., McCarson, K. & DiMaggio, D., Jul 2 1993, In: Regulatory Peptides. 46, 1-2, p. 59-66 8 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
The roles of the putative third cytoplasmic loop and cytoplasmic carboxyl tail of NK-1 and NK-2 receptors in agonist stimulated second messenger responses in stably transfected CHO cells
Blount, P. & Krause, J. E., Jul 2 1993, In: Regulatory Peptides. 46, 1-2, p. 447-449 3 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
1994
A large-conductance mechanosensitive channel in E. coli encoded by mscL alone
Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R. & Kung, C., 1994, In: Nature. 368, 6468, p. 265-268 4 p.Research output: Contribution to journal › Article › peer-review
612 Scopus citations -
Functional reconstitution as an assay for biochemical isolation of channel proteins: Application to the molecular identification of a bacterial mechanosensitive channel
Sukharev, S. I., Martinac, B., Blount, P. & Kung, C., Mar 1994, In: Methods. 6, 1, p. 51-59 9 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
1996
Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli
Blount, P., Sukharev, S. I., Moe, P. C., Schroeder, M. J., Guy, H. R. & Kung, C., Sep 16 1996, In: EMBO Journal. 15, 18, p. 4798-4805 8 p.Research output: Contribution to journal › Article › peer-review
Open Access165 Scopus citations -
Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli
Blount, P., Sukharev, S. I., Schroeder, M. J., Nagle, S. K. & Kung, C., Oct 15 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 21, p. 11652-11657 6 p.Research output: Contribution to journal › Article › peer-review
182 Scopus citations -
1997
Mechanosensitive channels of E. coli: A genetic and molecular dissection
Blount, P., Sukharev, S. I., Moe, P. & Kung, C., Feb 1997, In: Biological Bulletin. 192, 1, p. 126-130 5 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress
Blount, P., Schroeder, M. J. & Kung, C., Dec 19 1997, In: Journal of Biological Chemistry. 272, 51, p. 32150-32157 8 p.Research output: Contribution to journal › Article › peer-review
97 Scopus citations -
1998
Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation
Woe, P. C., Blount, P. & Kung, C., 1998, In: Molecular Microbiology. 28, 3, p. 583-592 10 p.Research output: Contribution to journal › Article › peer-review
116 Scopus citations -
Helicity, membrane incorporation, orientation and thermal stability of the large conductance mechanosensitive ion channel from E. coli
Arkin, I. T., Sukharev, S. I., Blount, P., Kung, C. & Brünger, A. T., Feb 2 1998, In: Biochimica et Biophysica Acta - Biomembranes. 1369, 1, p. 131-140 10 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
One face of a transmembrane helix is crucial in mechanosensitive channel gating
Ou, X., Blount, P., Hoffman, R. J. & Kung, C., Sep 15 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 19, p. 11471-11475 5 p.Research output: Contribution to journal › Article › peer-review
Open Access172 Scopus citations -
1999
Differential channeling of sensory stimuli onto a motor neuron in the leech
Iscla, I., Arini, P. D. & Szczupak, L., Feb 1999, In: Journal of Comparative Physiology - A Sensory, Neural, and Behavioral Physiology. 184, 2, p. 233-241 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity
Yoshimura, K., Batiza, A., Schroeder, M., Blount, P. & Kung, C., Oct 1999, In: Biophysical journal. 77, 4, p. 1960-1972 13 p.Research output: Contribution to journal › Article › peer-review
Open Access168 Scopus citations -
Mechanosensitive channels of bacteria
Blount, P., Sukharev, S. I., Moe, P. C., Martinac, B. & Kung, C., Jan 1 1999, In: Methods in Enzymology. 294, p. 458-482 25 p.Research output: Contribution to journal › Article › peer-review
121 Scopus citations -
2000
Correlating a protein structure with function of a bacterial mechanosensitive channel
Moe, P. C., Levin, G. & Blount, P., Oct 6 2000, In: Journal of Biological Chemistry. 275, 40, p. 31121-31127 7 p.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
2002
Family ties of gated pores: Evolution of the sensor module
Kumánovics, A., Levin, G. & Blount, P., Oct 2002, In: FASEB Journal. 16, 12, p. 1623-1629 7 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
Functional design of bacterial mechanosensitive channels. Comparisons and contrasts illuminated by random mutagenesis
Okada, K., Moe, P. C. & Blount, P., Aug 2 2002, In: Journal of Biological Chemistry. 277, 31, p. 27682-27688 7 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Ionic regulation of MSCk, a mechanosensitive channel from Escherichia coli
Li, Y., Moe, P. C., Chandrasekaran, S., Booth, I. R. & Blount, P., Oct 15 2002, In: EMBO Journal. 21, 20, p. 5323-5330 8 p.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
The effect of diamide on the expression of macrophage inflammatory protein-1 alpha in endothelial cells
Yang, L., Zhu, X., Zhao, X. & Deng, Z., Oct 2002, In: Zhonghua bing li xue za zhi Chinese journal of pathology. 31, 5, p. 427-431 5 p.Research output: Contribution to journal › Article › peer-review
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2003
Inhibition of magnesium lithospermate B on the c-Jun N-terminal kinase 3 mRNA expression in cardiomyocytes encountered ischemia/reperfusion injury
Yang, L. M., Xiao, Y. L. & Ou-Yang, J. H., Jul 1 2003, In: Yaoxue Xuebao. 38, 7, p. 487-491 5 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Lipopolysaccharide induces expression of macrophage inflammatory protein-1alpha in human umbilical vein endothelial cells
Deng, Z. D., Qu, Z. L. & Yang, L. M., Oct 2003, In: Zhonghua bing li xue za zhi Chinese journal of pathology. 32, 5, p. 449-452 4 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2004
An in vivo assay identifies changes in residue accessibility on mechanosensitive channel gating
Bartlett, J. L., Levin, G. & Blount, P., Jul 6 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 27, p. 10161-10165 5 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Cysteine Scanning of MscL Transmembrane Domains Reveals Residues Critical for Mechanosensitive Channel Gating
Levin, G. & Blount, P., May 2004, In: Biophysical journal. 86, 5, p. 2862-2870 9 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites
Iscla, I., Levin, G., Wray, R., Reynolds, R. & Blount, P., Nov 2004, In: Biophysical journal. 87, 5, p. 3172-3180 9 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Intragenic suppression of gain-of-function mutations in the Escherichia coli mechanosensitive channel, MscL
Li, Y., Wray, R. & Blount, P., Jul 2004, In: Molecular Microbiology. 53, 2, p. 485-495 11 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
Rodriguez, M. J., Iscla, I. R. & Szczupak, L., May 2004, In: Journal of neurophysiology. 91, 5, p. 2366-2375 10 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2005
Assessment of potential stimuli for mechano-dependent gating of MscL: Effects of pressure, tension, and lipid headgroups
Moe, P. & Blount, P., Sep 13 2005, In: Biochemistry. 44, 36, p. 12239-12244 6 p.Research output: Contribution to journal › Article › peer-review
161 Scopus citations -
Lactococcus lactis uses MscL as its principal mechanosensitive channel
Folgering, J. H. A., Moe, P. C., Schuurman-Wolters, G. K., Blount, P. & Poolman, B., Mar 11 2005, In: Journal of Biological Chemistry. 280, 10, p. 8784-8792 9 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel
Edwards, M. D., Li, Y., Kim, S., Miller, S., Bartlett, W., Black, S., Dennison, S., Iscla, I., Blount, P., Bowie, J. U. & Booth, I. R., Feb 20 2005, In: Nature Structural and Molecular Biology. 12, 2, p. 113-119 7 p.Research output: Contribution to journal › Article › peer-review
108 Scopus citations -
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system
Calviño, M. A., Iscla, I. R. & Szczupak, L., May 2005, In: Journal of neurophysiology. 93, 5, p. 2644-2655 12 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
2006
Mechanosensitive channel gating transitions resolved by functional changes upon pore modification
Bartlett, J. L., Li, Y. & Blount, P., Nov 2006, In: Biophysical journal. 91, 10, p. 3684-3691 8 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's β- and γ-subunit
Yang, L. M., Rinke, R. & Korbmacher, C., Apr 14 2006, In: Journal of Biological Chemistry. 281, 15, p. 9859-9868 10 p.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
2007
Disulfide trapping the mechanosensitive channel MscL into a gating-transition state
Iscla, I., Levin, G., Wray, R. & Blount, P., Feb 2007, In: Biophysical journal. 92, 4, p. 1224-1232 9 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
MscL: The Bacterial Mechanosensitive Channel of Large Conductance
Blount, P., Iscla, I., Moe, P. C. & Li, Y., 2007, In: Current Topics in Membranes. 58, p. 201-233 33 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2008
On the structure of the N-terminal domain of the MscL channel: Helical bundle or membrane interface
Iscla, I., Wray, R. & Blount, P., Sep 1 2008, In: Biophysical journal. 95, 5, p. 2283-2291 9 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations