Research output per year
Research output per year
- 1 - 50 out of 116 results
Search results
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2024
Mimicking Protein Kinase C Phosphorylation Inhibits Arc/Arg3.1 Palmitoylation and Its Interaction with Nucleic Acids
Barylko, B., Taylor, C. A., Wang, J., Earnest, S., Stippec, S., Binns, D. D., Brautigam, C. A., Jameson, D. M., DeMartino, G. N., Cobb, M. H. & Albanesi, J. P., Jan 2024, In: International journal of molecular sciences. 25, 2, 780.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Differential Interactions of the Proteasome Inhibitor PI31 with Constitutive and Immuno-20S Proteasomes
Wang, J., Kjellgren, A. & DeMartino, G. N., 2023, (Accepted/In press) In: Biochemistry.Research output: Contribution to journal › Article › peer-review
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Ηigh-resolution structure of mammalian PI31–20S proteasome complex reveals mechanism of proteasome inhibition
Hsu, H. C., Wang, J., Kjellgren, A., Li, H. & DeMartino, G. N., Jul 2023, In: Journal of Biological Chemistry. 299, 7, 104862.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2022
Highly conserved shifts in ubiquitin-proteasome system (UPS) activity drive mitochondrial remodeling during quiescence
Yue, S., Wang, L., DeMartino, G. N., Zhao, F. Z., Liu, Y. & Sieber, M. H., Dec 2022, In: Nature communications. 13, 1, 4462.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2019
Celebrating science’s next generation
Gierasch, L. M. & De Martino, G., Mar 1 2019, In: Journal of Biological Chemistry. 294, 9, p. 3323-3324 2 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2016
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs
Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., Demartino, G. N., Young, R. A., Sonenberg, N. & Morrison, S. J., Aug 1 2016, In: Genes and Development. 30, 15, p. 1698-1703 6 p.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
2014
Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function
Li, X., Thompson, D., Kumar, B. & DeMartino, G. N., Jun 20 2014, In: Journal of Biological Chemistry. 289, 25, p. 17392-17405 14 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
2013
ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome
Kim, Y. C., Li, X., Thompson, D. & Demartino, G. N., Feb 1 2013, In: Journal of Biological Chemistry. 288, 5, p. 3334-3345 12 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
2012
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95
Tsai, N. P., Wilkerson, J. R., Guo, W., Maksimova, M. A., Demartino, G. N., Cowan, C. W. & Huber, K. M., Dec 21 2012, In: Cell. 151, 7, p. 1581-1594 14 p.Research output: Contribution to journal › Article › peer-review
219 Scopus citations -
2011
C termini of proteasomal ATpases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome
Kim, Y. C. & DeMartino, G. N., Jul 29 2011, In: Journal of Biological Chemistry. 286, 30, p. 26652-26666 15 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
2010
Accelerated formation of α-synuclein oligomers by concerted action of the 20s proteasome and familial parkinson mutations
Lewis, K. A., Yaeger, A., Demartino, G. N. & Thomas, P. J., Feb 2010, In: Journal of Bioenergetics and Biomembranes. 42, 1, p. 85-95 11 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome
Agarwal, A. K., Xing, C., Demartino, G. N., Mizrachi, D., Hernandez, M. D., Sousa, A. B., Martínez De Villarreal, L., Dos Santos, H. G. & Garg, A., Dec 10 2010, In: American Journal of Human Genetics. 87, 6, p. 866-872 7 p.Research output: Contribution to journal › Article › peer-review
266 Scopus citations -
The C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation
Kumar, B., Kim, Y. C. & DeMartino, G. N., Dec 10 2010, In: Journal of Biological Chemistry. 285, 50, p. 39523-39535 13 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
2009
Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes
Ikeda, Y., DeMartino, G. N., Brown, M. S., Lee, J. N., Goldstein, J. L. & Ye, J., Dec 11 2009, In: Journal of Biological Chemistry. 284, 50, p. 34889-34900 12 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II
Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N. & Patrick, G. N., Sep 25 2009, In: Journal of Biological Chemistry. 284, 39, p. 26655-26665 11 p.Research output: Contribution to journal › Article › peer-review
198 Scopus citations -
Subcomplexes of PA700, the 19 S regulator of the 26 S proteasome, reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activity
Thompson, D., Hakala, K. & DeMartino, G. N., Sep 11 2009, In: Journal of Biological Chemistry. 284, 37, p. 24891-24903 13 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Variably modulated gating of the 26S proteasome by ATP and polyubiquitin
Li, X. & DeMartino, G. N., Aug 1 2009, In: Biochemical Journal. 421, 3, p. 397-404 8 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
2008
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and Activation of the 26 S proteasome
Gillette, T. G., Kumar, B., Thompson, D., Slaughter, C. A. & DeMartino, G. N., Nov 14 2008, In: Journal of Biological Chemistry. 283, 46, p. 31813-31822 10 p.Research output: Contribution to journal › Article › peer-review
130 Scopus citations -
JAMP optimizes ERAD to protect cells from unfolded proteins
Tcherpakov, M., Broday, L., Delaunay, A., Kadoya, T., Khurana, A., Erdjument-Bromage, H., Tempst, P., Qiu, X. B., Demartino, G. N. & Ronai, Z., Nov 2008, In: Molecular biology of the cell. 19, 11, p. 5019-5028 10 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome
Koulich, E., Li, X. & DeMartino, G. N., Mar 2008, In: Molecular biology of the cell. 19, 3, p. 1072-1082 11 p.Research output: Contribution to journal › Article › peer-review
180 Scopus citations -
2007
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., Badano, J. L. & Katsanis, N., Nov 2007, In: Nature genetics. 39, 11, p. 1350-1360 11 p.Research output: Contribution to journal › Article › peer-review
337 Scopus citations -
Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System
Wahlman, J., DeMartino, G. N., Skach, W. R., Bulleid, N. J., Brodsky, J. L. & Johnson, AE., Jun 1 2007, In: Cell. 129, 5, p. 943-955 13 p.Research output: Contribution to journal › Article › peer-review
113 Scopus citations -
2006
ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome
Liu, C. W., Li, X., Thompson, D., Wooding, K., Chang, T. L., Tang, Z., Yu, H., Thomas, P. J. & DeMartino, G. N., Oct 6 2006, In: Molecular cell. 24, 1, p. 39-50 12 p.Research output: Contribution to journal › Article › peer-review
149 Scopus citations -
Modification of Cul1 regulates its association with proteasomal subunits
Bloom, J., Peschiaroli, A., DeMartino, G. & Pagano, M., Apr 28 2006, In: Cell Division. 1, 5.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
Yao, T., Song, L., Xu, W., DeMartino, G. N., Florens, L., Swanson, S. K., Washburn, M. P., Conaway, R. C., Conaway, J. W. & Cohen, R. E., Sep 2006, In: Nature cell biology. 8, 9, p. 994-1002 9 p.Research output: Contribution to journal › Article › peer-review
278 Scopus citations -
Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells
Wójcik, C., Rowicka, M., Kudlicki, A., Nowis, D., McConnell, E., Kujawa, M. & DeMartino, G. N., Nov 2006, In: Molecular biology of the cell. 17, 11, p. 4606-4618 13 p.Research output: Contribution to journal › Article › peer-review
Open Access157 Scopus citations -
2005
A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: Implications for pathogenesis of parkinson disease
Liu, C. W., Giasson, B. I., Lewis, K. A., Lee, V. M., DeMartino, G. N. & Thomas, P. J., Jun 17 2005, In: Journal of Biological Chemistry. 280, 24, p. 22670-22678 9 p.Research output: Contribution to journal › Article › peer-review
228 Scopus citations -
Modulation of gene expression by RNAi.
Wójcik, C., Fabunmi, R. & DeMartino, G. N., 2005, In: Methods in molecular medicine. 108, p. 381-393 13 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome.
Liu, C. W., Strickland, E., Demartino, G. N. & Thomas, P. J., 2005, In: Methods in molecular biology (Clifton, N.J.). 301, p. 71-81 11 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2004
RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis
Wójcik, C., Yano, M. & DeMartino, G. N., Jan 15 2004, In: Journal of cell science. 117, 2, p. 281-292 12 p.Research output: Contribution to journal › Article › peer-review
211 Scopus citations -
Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein
Lee, R. J., Liu, C. W., Harty, C., McCracken, A. A., Latterich, M., Römisch, K., DeMartino, G. N., Thomas, P. J. & Brodsky, J. L., Jun 2 2004, In: EMBO Journal. 23, 11, p. 2206-2215 10 p.Research output: Contribution to journal › Article › peer-review
Open Access101 Scopus citations -
2003
Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes
Puttaparthi, K., Wojcik, C., Rajendran, B., DeMartino, G. N. & Elliott, J. L., Nov 2003, In: Journal of Neurochemistry. 87, 4, p. 851-860 10 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
Endoproteolytic activity of the proteasome
Liu, C. W., Corboy, M. J., DeMartino, G. N. & Thomas, P. J., Jan 17 2003, In: Science. 299, 5605, p. 408-411 4 p.Research output: Contribution to journal › Article › peer-review
359 Scopus citations -
Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation
Bloom, J., Amador, V., Bartolini, F., DeMartino, G. & Pagano, M., Oct 3 2003, In: Cell. 115, 1, p. 71-82 12 p.Research output: Contribution to journal › Article › peer-review
270 Scopus citations -
2002
Analysis of Drosophila 26 S proteasome using RNA interference
Wójcikb, C. & Demartino, G. N., Feb 22 2002, In: Journal of Biological Chemistry. 277, 8, p. 6188-6197 10 p.Research output: Contribution to journal › Article › peer-review
94 Scopus citations -
Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome
Liu, C. W., Millen, L., Roman, T. B., Xiong, H., Gilbert, H. F., Noiva, R., Demartino, G. N. & Thomas, P. J., Jul 26 2002, In: Journal of Biological Chemistry. 277, 30, p. 26815-26820 6 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
2001
Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies
Fabunmi, R. P., Christian Wigley, W., Thomas, P. J. & DeMartino, G. N., 2001, In: Journal of cell science. 114, 1, p. 29-36 8 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
2000
Activity and regulation of the centrosome-associated proteasome
Fabunmi, R. P., Wigley, W. C., Thomas, P. J. & DeMartino, G. N., Jan 7 2000, In: Journal of Biological Chemistry. 275, 1, p. 409-413 5 p.Research output: Contribution to journal › Article › peer-review
142 Scopus citations -
cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome
McCutchen-Maloney, S. L., Matsuda, K., Shimbara, N., Binns, D. D., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 16 2000, In: Journal of Biological Chemistry. 275, 24, p. 18557-18565 9 p.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle
Ordway, G. A., Neufer, P. D., Chin, E. R. & DeMartino, G. N., Mar 2000, In: Journal of applied physiology. 88, 3, p. 1134-1141+1133Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Cotranslatioaal dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production
Lin, L., DeMartino, G. N. & Greene, W. C., Sep 1 2000, In: EMBO Journal. 19, 17, p. 4712-4722 11 p.Research output: Contribution to journal › Article › peer-review
93 Scopus citations -
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
Strickland, E., Hakala, K., Thomas, P. J. & DeMartino, G. N., Feb 25 2000, In: Journal of Biological Chemistry. 275, 8, p. 5565-5572 8 p.Research output: Contribution to journal › Article › peer-review
165 Scopus citations -
1999
26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate
Ben-Shahar, S., Komlosh, A., Nadav, E., Shaked, I., Ziv, T., Admon, A., DeMartino, G. N. & Reiss, Y., Jul 30 1999, In: Journal of Biological Chemistry. 274, 31, p. 21963-21972 10 p.Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
Dynamic association of proteasomal machinery with the centrosome
Wigley, C. W., Fabunmi, R. P., Lee, M. G., Marino, C. R., Muallem, S., DeMartino, G. N. & Thomas, P. J., May 3 1999, In: Journal of Cell Biology. 145, 3, p. 481-490 10 p.Research output: Contribution to journal › Article › peer-review
441 Scopus citations -
Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone
Stenoien, D. L., Cummings, C. J., Adams, H. P., Mancini, M. G., Patel, K., Demartino, G. N., Marcelli, M., Weigel, N. L. & Mancini, M. A., 1999, In: Human molecular genetics. 8, 5, p. 731-741 11 p.Research output: Contribution to journal › Article › peer-review
Open Access394 Scopus citations -
1998
9 ubiquitin-proteasome pathway of intracellular protein degradation
DeMartino, G. N. & Ordway, G. A., Jan 1998, In: Exercise and Sport Sciences Reviews. 26, 1, p. 219-252 34 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9)
Watanabe, T. K., Saito, A., Suzuki, M., Fujiwara, T., Takahashi, E. I., Slaughter, C. A., DeMartino, G. N., Hendil, K. B., Chung, C. H., Tanahashi, N. & Tanaka, K., Jun 1 1998, In: Genomics. 50, 2, p. 241-250 10 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome
Hori, T., Kato, S., Saeki, M., DeMartino, G. N., Slaughter, C. A., Takeuchi, J., Toh-e, A. & Tanaka, K., Aug 17 1998, In: Gene. 216, 1, p. 113-122 10 p.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
Cotranslational biogenesis of NF-κB p50 by the 26S proteasome
Lin, L., DeMartino, G. N. & Greene, W. C., Mar 20 1998, In: Cell. 92, 6, p. 819-828 10 p.Research output: Contribution to journal › Article › peer-review
261 Scopus citations -
Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity
Adams, G. M., Crotchett, B., Slaughter, C. A., DeMartino, G. N. & Gogol, E. P., Sep 15 1998, In: Biochemistry. 37, 37, p. 12927-12932 6 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations