Research output per year
Research output per year
- 49 results
Search results
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Activation of human STING by a molecular glue-like compound
Li, J., Canham, S. M., Wu, H., Henault, M., Chen, L., Liu, G., Chen, Y., Yu, G., Miller, H. R., Hornak, V., Brittain, S. M., Michaud, G. A., Tutter, A., Broom, W., Digan, M. E., McWhirter, S. M., Sivick, K. E., Pham, H. T., Chen, C. H., Tria, G. S., & 15 others, Mar 2024, In: Nature chemical biology. 20, 3, p. 365-372 8 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Activation of STING by targeting a pocket in the transmembrane domain
Lu, D., Shang, G., Li, J., Lu, Y., Bai, X. C. & Zhang, X., Apr 21 2022, In: Nature. 604, 7906, p. 557-562 6 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Zhang, X., Gureasko, J., Shen, K., Cole, P. A. & Kuriyan, J., Jun 2006, In: Cell. 125, 6, p. 1137-1149 13 p.Research output: Contribution to journal › Article › peer-review
1246 Scopus citations -
A putative structural mechanism underlying the antithetic effect of homologous rnd1 and rhod gtpases in mammalian plexin regulation
Liu, Y., Ke, P., Kuo, Y. C., Wang, Y., Zhang, X., Song, C. & Shan, Y., Jun 2021, In: eLife. 10, e64304.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex
Lu, D., Shang, G., He, X., Bai, X. C. & Zhang, X., Dec 1 2021, In: Nature communications. 12, 1, 3172.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface
Marita, M., Wang, Y., Kaliszewski, M. J., Skinner, K. C., Comar, W. D., Shi, X., Dasari, P., Zhang, X. & Smith, A. W., Nov 3 2015, In: Biophysical journal. 109, 9, p. 1937-1945 9 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands
Li, J., Shang, G., Chen, Y. J., Brautigam, C. A., Liou, J., Zhang, X. & Bai, X. C., Sep 2019, In: eLife. 8, e47650.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Cryo-EM structure of the Hippo signaling integrator human STRIPAK
Jeong, B. C., Bae, S. J., Ni, L., Zhang, X., Bai, X. C. & Luo, X., Mar 2021, In: Nature Structural and Molecular Biology. 28, 3, p. 290-299 10 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
Kuo, Y. C., Chen, H., Shang, G., Uchikawa, E., Tian, H., Bai, X. C. & Zhang, X., Dec 1 2020, In: Nature communications. 11, 1, 1953.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Shang, G., Zhang, C., Chen, Z. J., Bai, X. C. & Zhang, X., Mar 21 2019, In: Nature. 567, 7748, p. 389-393 5 p.Research output: Contribution to journal › Article › peer-review
Open Access361 Scopus citations -
Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2
Zhang, X., Schwartz, J. C. D., Nathenson, S. G. & Almo, S. C., 2001, In: Acta Crystallographica Section D: Biological Crystallography. 57, 6, p. 898-899 2 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling
Zhang, X., Schwartz, J. C. D., Almo, S. C. & Nathenson, S. G., Mar 4 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 5, p. 2586-2591 6 p.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
Cyclic GMP-AMP containing mixed Phosphodiester linkages is an endogenous high-affinity ligand for STING
Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C. & Chen, Z., Jul 25 2013, In: Molecular cell. 51, 2, p. 226-235 10 p.Research output: Contribution to journal › Article › peer-review
741 Scopus citations -
Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells
Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In: Molecular and cellular biology. 35, 14, p. 2425-2435 11 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC
Yamasaki, T., Tran, T. A. T., Oz, O. K., Raj, G. V., Schwarz, R. E., DeBerardinis, R. J., Zhang, X. & Brugarolas, J., Apr 2011, In: Nature Reviews Urology. 8, 3, p. 165-171 7 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2
Zhang, X., Schwartz, J. C. D., Almo, S. C. & Nathenson, S. G., 2002, In: Protein Expression and Purification. 25, 1, p. 105-113 9 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
Wu, X., Zhang, L. S., Toombs, J., Kuo, Y. C., Piazza, J. T., Tuladhar, R., Barrett, Q., Fan, C. W., Zhang, X., Walensky, L. D., Kool, M., Cheng, S. Y., Brekken, R., Opferman, J. T., Green, D. R., Moldoveanu, T. & Lum, L., Sep 29 2017, In: Nature cell biology. 19, 10, p. 1226-1236 11 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly
Benning, F. M. C., Jenni, S., Garcia, C. Y., Nguyen, T. H., Zhang, X. & Chao, L. H., Dec 2024, In: Nature communications. 15, 1, 250.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease
Falta, M. T., Pinilla, C., Mack, D. G., Tinega, A. N., Crawford, F., Giulianotti, M., Santos, R., Clayton, G. M., Wang, Y., Zhang, X., Maier, L. A., Marrack, P., Kappler, J. W. & Fontenot, A. P., Jul 2013, In: Journal of Experimental Medicine. 210, 7, p. 1403-1418 16 p.Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold
Liu, S., Chen, H., Yin, Y., Lu, D., Gao, G., Li, J., Bai, X. C. & Zhang, X., Apr 7 2023, In: Science Advances. 9, 14, eadf5583.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Zhang, X., Pickin, K. A., Bose, R., Jura, N., Cole, P. A. & Kuriyan, J., Nov 29 2007, In: Nature. 450, 7170, p. 741-744 4 p.Research output: Contribution to journal › Article › peer-review
294 Scopus citations -
In vitro assay for the Rap GTPase-activating protein activity of the purified cytoplasmic domain of plexin
Pascoe, H. G., Wang, Y. & Zhang, X., 2017, In: Methods in Molecular Biology. 1493, p. 107-118 12 p.Research output: Contribution to journal › Article › peer-review
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Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
Jura, N., Endres, N. F., Engel, K., Deindl, S., Das, R., Lamers, M. H., Wemmer, D. E., Zhang, X. & Kuriyan, J., Jun 26 2009, In: Cell. 137, 7, p. 1293-1307 15 p.Research output: Contribution to journal › Article › peer-review
446 Scopus citations -
Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ
Wu, X., Zhao, Y., Zhang, H., Yang, W., Yang, J., Sun, L., Jiang, M., Wang, Q., Wang, Q., Ye, X., Zhang, X. & Wu, Y., Dec 2023, In: Nature communications. 14, 1, 479.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
Qi, N., Shi, Y., Zhang, R., Zhu, W., Yuan, B., Li, X., Wang, C., Zhang, X. & Hou, F., Jun 13 2017, In: Nature communications. 8, 15676.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
Shan, Y., Eastwood, M. P., Zhang, X., Kim, E. T., Arkhipov, A., Dror, R. O., Jumper, J., Kuriyan, J. & Shaw, D. E., May 11 2012, In: Cell. 149, 4, p. 860-870 11 p.Research output: Contribution to journal › Article › peer-review
273 Scopus citations -
Orthogonal Hydroxyl Functionalization of cGAMP Confers Metabolic Stability and Enables Antibody Conjugation
Chen, C., Lu, Y., You, L., Li, L., Kilgore, J. A., Liu, S., Wang, X., Dai, Y., Wei, Q., Shi, H., Han, L., Sun, L., Chen, Z. J., Zhang, X. & Williams, N. S., Dec 27 2023, In: ACS Central Science. 9, 12, p. 2298-2305 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization
Wang, Y., He, H., Srivastava, N., Vikarunnessa, S., Chen, Y. B., Jiang, J., Cowan, C. W. & Zhang, X., Jan 17 2012, In: Science signaling. 5, 207, ra6.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
Plexins function in epithelial repair in both Drosophila and zebrafish
Yoo, S. K., Pascoe, H. G., Pereira, T., Kondo, S., Jacinto, A., Zhang, X. & Hariharan, I. K., Jul 25 2016, In: Nature communications. 7, 12282.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Python-based Helix Indexer: A graphical user interface program for finding symmetry of helical assembly through Fourier–Bessel indexing of electron microscopic data
Zhang, X., Jan 2022, In: Protein Science. 31, 1, p. 107-117 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Regulation of tankyrase activity by a catalytic domain dimer interface
Fan, C., Yarravarapu, N., Chen, H., Kulak, O., Dasari, P., Herbert, J., Yamaguchi, K., Lum, L. & Zhang, X., Sep 10 2018, In: Biochemical and Biophysical Research Communications. 503, 3, p. 1780-1785 6 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZâ€"RhoGEF
Pascoe, H. G., Gutowski, S., Chen, H., Brautigam, C. A., Chen, Z., Sternweis, P. C. & Zhang, X., Dec 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14852-14857 6 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex
Stepien, K. P., Xu, J., Zhang, X., Bai, X. C. & Rizo, J., Jun 2022, In: Science Advances. 8, 25, eabo5272.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Sorting nexin 5 mediates virus-induced autophagy and immunity
Dong, X., Yang, Y., Zou, Z., Zhao, Y., Ci, B., Zhong, L., Bhave, M., Wang, L., Kuo, Y. C., Zang, X., Zhong, R., Aguilera, E. R., Richardson, R. B., Simonetti, B., Schoggins, J. W., Pfeiffer, J. K., Yu, L., Zhang, X., Xie, Y., Schmid, S. L., & 6 others, Jan 21 2021, In: Nature. 589, 7842, p. 456-461 6 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Structural analyses of FERM domain-mediated membrane localization of FARP1
Kuo, Y. C., He, X., Coleman, A. J., Chen, Y. J., Dasari, P., Liou, J., Biederer, T. & Zhang, X., Dec 1 2018, In: Scientific reports. 8, 1, 10477.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Structural analysis and functional implications of the negative mTORC1 regulator REDD1
Vega-Rubin-de-Celis, S., Abdallah, Z., Kinch, L., Grishin, N. V., Brugarolas, J. & Zhang, X., Mar 23 2010, In: Biochemistry. 49, 11, p. 2491-2501 11 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
Structural and Functional Analyses of the FAM46C/Plk4 Complex
Chen, H., Lu, D., Shang, G., Gao, G. & Zhang, X., Aug 4 2020, In: Structure. 28, 8, p. 910-921.e4Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Structural and functional analysis of the costimulatory receptor programmed death-1
Zhang, X., Schwartz, J. C. D., Guo, X., Bhatia, S., Cao, E., Chen, L., Zhang, Z. Y., Edidin, M. A., Nathenson, S. G. & Almo, S. C., Mar 2004, In: Immunity. 20, 3, p. 337-347 11 p.Research output: Contribution to journal › Article › peer-review
324 Scopus citations -
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin
Wang, Y., Pascoe, H. G., Brautigam, C. A., He, H. & Zhang, X., Oct 1 2013, In: eLife. 2013, 2, e01279.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2
He, X., Kuo, Y. C., Rosche, T. J. & Zhang, X., Mar 5 2013, In: Structure. 21, 3, p. 355-364 10 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
Schwartz, J. C. D., Zhang, X., Fedorov, A. A., Nathenson, S. G. & Almo, S. C., Mar 29 2001, In: Nature. 410, 6828, p. 604-608 5 p.Research output: Contribution to journal › Article › peer-review
293 Scopus citations -
Structural basis for the prion-like MAVS filaments in antiviral innate immunity
Xu, H., He, X., Zheng, H., Huang, L. J., Hou, F., Yu, Z., de la Cruz, M. J., Borkowski, B., Zhang, X., Chen, Z. J. & Jiang, Q. X., Feb 25 2014, In: eLife. 2014, 3, e01489.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
Structural basis of insulin fibrillation
Wang, L., Hall, C. E., Uchikawa, E., Chen, D., Choi, E., Zhang, X. & Bai, X. C., 2023, In: Science Advances. 9, 37, eadi1057.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Structural basis of STING binding with and phosphorylation by TBK1
Zhang, C., Shang, G., Gui, X., Zhang, X., Bai, X. C. & Chen, Z. J., Mar 21 2019, In: Nature. 567, 7748, p. 394-398 5 p.Research output: Contribution to journal › Article › peer-review
510 Scopus citations -
Structural basis of the activation of c-MET receptor
Uchikawa, E., Chen, Z., Xiao, G. Y., Zhang, X. & Bai, X. C., Dec 1 2021, In: Nature communications. 12, 1, 4074.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex
Shang, G., Brautigam, C. A., Chen, R., Lu, D., Torres-Vázquez, J. & Zhang, X., May 24 2017, In: eLife. 6, e27322.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Synergistic activation of the insulin receptor via two distinct sites
Li, J., Park, J., Mayer, J. P., Webb, K. J., Uchikawa, E., Wu, J., Liu, S., Zhang, X., Stowell, M. H. B., Choi, E. & Bai, X. C., Apr 2022, In: Nature Structural and Molecular Biology. 29, 4, p. 357-368 12 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In: Cell Reports. 6, 3, p. 421-430 10 p.Research output: Contribution to journal › Article › peer-review
329 Scopus citations -
Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production
He, S., Zhao, J., Song, S., He, X., Minassian, A., Zhou, Y., Zhang, J., Brulois, K., Wang, Y., Cabo, J., Zandi, E., Liang, C., Jung, J. U., Zhang, X. & Feng, P., Apr 2 2015, In: Molecular cell. 58, 1, p. 134-146 13 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations