Pharmacology - Mangelsdorf Lab – Research output — University of Texas Southwestern Medical Center

2023

FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system

Choi, M., Schneeberger, M., Fan, W., Bugde, A., Gautron, L., Vale, K., Hammer, R. E., Zhang, Y., Friedman, J. M., Mangelsdorf, D. J. & Kliewer, S. A., Mar 7 2023, In: Cell Metabolism. 35, 3, p. 429-437.e5

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers

Huffman, K. E., Li, L. S., Carstens, R., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R., Timmons, B., Sudderth, J., Bendris, N., Kim, J., Villalobos, P., Fujimoto, J., Schmid, S., Deberardinis, R. J., Wistuba, I., Heymach, J., Kittler, R., Akbay, E. A., & 6 othersPosner, B., Wang, Y., Lam, S., Kliewer, S. A., Mangelsdorf, D. J. & Minna, J. D., 2023, In: Frontiers in Oncology. 13, 1025443.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT

Zechner, C., Mike Henne, W., Sathe, A. A., Xing, C., Hernandez, G., Sun, S. & Cheong, M. C., Jun 1 2022, In: Journal of Biological Chemistry. 298, 6, 101945.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis

Zhang, Z., Jiang, Y., Su, L., Ludwig, S., Zhang, X., Tang, M., Li, X., Anderton, P., Zhan, X., Choi, M., Russell, J., Bu, C. H., Lyon, S., Xu, D., Hildebrand, S., Scott, L., Quan, J., Simpson, R., Sun, Q., Qin, B., & 4 othersCollie, T., Tadesse, M., Moresco, E. M. Y. & Beutler, B., Nov 1 2022, In: Cell Metabolism. 34, 11, p. 1860-1874.e4

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis inmice

Zhong, X., Choi, J. H., Hildebrand, S., Ludwig, S., Wang, J., Nair-Gill, E., Liao, T. C., Moresco, J. J., Liu, A., Quan, J., Sun, Q., Zhang, D., Zhan, X., Choi, M., Li, X., Wang, J., Gallagher, T., Moresco, E. M. Y. & Beutler, B., May 3 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 18, e2200128119.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

The energy balance model of obesity: beyond calories in, calories out

Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, R. J. F., Mangelsdorf, D. J., O'Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., Speakman, J. R. & Tobias, D. K., May 1 2022, In: American Journal of Clinical Nutrition. 115, 5, p. 1243-1254 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

The ‘nuclear option’ revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections

Lok, J. B., Kliewer, S. A. & Mangelsdorf, D. J., Jul 2022, In: Molecular and Biochemical Parasitology. 250, 111490.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2021

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

Wang, Z., Cheong, M. C., Tsien, J., Deng, H., Qin, T., Stoltzfus, J. D. C., Jaleta, T. G., Li, X., Lok, J. B., Kliewer, S. A. & Mangelsdorf, D. J., Dec 2021, In: eLife. 10, e73535.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Dominant atopy risk mutations identified by mouse forward genetic analysis

SoRelle, J. A., Chen, Z., Wang, J., Yue, T., Choi, J. H., Wang, K. W., Zhong, X., Hildebrand, S., Russell, J., Scott, L., Xu, D., Zhan, X., Bu, C. H., Wang, T., Choi, M., Tang, M., Ludwig, S., Zhan, X., Li, X., Moresco, E. M. Y., & 1 othersBeutler, B., Apr 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, 4, p. 1095-1108 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

Abu-Odeh, M., Zhang, Y., Reilly, S. M., Ebadat, N., Keinan, O., Valentine, J. M., Hafezi-Bakhtiari, M., Ashayer, H., Mamoun, L., Zhou, X., Zhang, J., Yu, R. T., Dai, Y., Liddle, C., Downes, M., Evans, R. M., Kliewer, S. A., Mangelsdorf, D. J. & Saltiel, A. R., Jun 29 2021, In: Cell Reports. 35, 13, 109331.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis

Cheong, M. C., Wang, Z., Jaleta, T. G., Li, X., Lok, J. B., Kliewer, S. A. & Mangelsdorf, D. J., Feb 23 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 8, e2021864118.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3

Romero, A. A., Cobb, S. A., Collins, J. N. R., Kliewer, S. A., Mangelsdorf, D. J. & Collins, J. J., Dec 2021, In: PLoS pathogens. 17, 12, e1010140.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning

Xu, D., Lyon, S., Bu, C. H., Hildebrand, S., Choi, J. H., Zhong, X., Liu, A., Turer, E. E., Zhang, Z., Russell, J., Ludwig, S., Mahrt, E., Nair-Gill, E., Shi, H., Wang, Y., Zhang, D., Yue, T., Wang, K. W., SoRelle, J. A., Su, L., & 35 othersMisawa, T., McAlpine, W., Sun, L., Wang, J., Zhan, X., Choi, M., Farokhnia, R., Sakla, A., Schneider, S., Coco, H., Coolbaugh, G., Hayse, B., Mazal, S., Medler, D., Nguyen, B., Rodriguez, E., Wadley, A., Tang, M., Li, X., Anderton, P., Keller, K., Press, A., Scott, L., Quan, J., Cooper, S., Collie, T., Qin, B., Cardin, J., Simpson, R., Tadesse, M., Sun, Q., Wise, C. A., Rios, J. J., Moresco, E. M. Y. & Beutler, B., Jul 13 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 28, e2106786118.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2020

A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans

Park, J. Y., Cheong, M. C., Cho, J. Y., Koo, H. S. & Paik, Y. K., Dec 1 2020, In: Scientific reports. 10, 1, 7524.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

Ayoade, K. O., Carranza, F. R., Cho, W. H., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Stoltzfus, J. D. C., Apr 1 2020, In: Parasites and Vectors. 13, 1, 162.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G., Luo, T., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A. & Mangelsdorf, D. J., Jan 8 2020, In: Science translational medicine. 12, 525, eaay5186.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2019

Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders

Katner, S. N., Bredhold, K. E., Steagall, K. B., Bell, R. L., Neal-Beliveau, B. S., Cheong, M. C. & Engleman, E. A., Jun 3 2019, In: Behavioural Brain Research. 365, p. 7-16 10 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang, D., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R., & 2 othersMoresco, E. Y. & Beutler, B., 2019, In: Science. 364, 6440, eaau0812.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Oct 1 2019, In: Nature immunology. 20, 10, p. 1322-1334 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

The orphan nuclear receptor SHP regulates er stress response by inhibiting XBP1s degradation

Sun, S., Kelekar, S., Kliewer, S. A. & Mangelsdorf, D. J., Aug 2019, In: Genes and Development. 33, 15-16, p. 1083-1094 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2018

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

Katafuchi, T., Holland, W. L., Kollipara, R. K., Kittler, R., Mangelsdorf, D. J. & Kliewer, S. A., Nov 27 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 48, p. 12102-12111 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

Song, P., Zechner, C. P. G., Hernandez, G., Cánovas, J., Xie, Y., Sondhi, V., Wagner, M., Stadlbauer, V., Horvath, A., Leber, B., Hu, M. C., Moe, O. W., Mangelsdorf, D. J. & Kliewer, S. A., Jun 5 2018, In: Cell Metabolism. 27, 6, p. 1338-1347.e4

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

2017

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J., Nov 7 2017, In: Cell Metabolism. 26, 5, p. 709-718.e3

Research output: Contribution to journal › Article › peer-review

Open Access

179 Scopus citations

FGF21 Is an Exocrine Pancreas Secretagogue

Coate, K. C., Hernandez, G., Thorne, C. A., Sun, S., Le, T. D. V., Vale, K., Kliewer, S. A. & Mangelsdorf, D. J., Feb 7 2017, In: Cell Metabolism. 25, 2, p. 472-480 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

2016

FGF21 regulates sweet and alcohol preference

Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., Bernardo, B., Müller, C. P., Tang, H., Mangelsdorf, D. J., Goodwin, B. & Kliewer, S. A., Feb 9 2016, In: Cell Metabolism. 23, 2, p. 344-349 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

232 Scopus citations

Impaired 17,20-lyase activity in male mice lacking cytochrome b₅ in leydig cells

Sondhi, V., Owen, B. M., Liu, J., Chomic, R., Kliewer, S. A., Hughes, B. A., Arlt, W., Mangelsdorf, D. J. & Auchus, R. J., Apr 2016, In: Molecular Endocrinology. 30, 4, p. 469-478 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., Lepe, M. S., Akira, S., Barbieri, C., Baumeister, S., Cauchi, S., Clarke, T. K., Enroth, S., Fischer, K., Hällfors, J., Harris, S. E., & 107 othersHieber, S., Hofer, E., Hottenga, J. J., Johansson, Å., Joshi, P. K., Kaartinen, N., Laitinen, J., Lemaitre, R., Loukola, A., Luan, J., Lyytikäinen, L. P., Mangino, M., Manichaikul, A., Mbarek, H., Milaneschi, Y., Moayyeri, A., Mukamal, K., Nelson, C., Nettleton, J., Partinen, E., Rawal, R., Robino, A., Rose, L., Sala, C., Satoh, T., Schmidt, R., Schraut, K., Scott, R., Smith, A. V., Starr, J. M., Teumer, A., Trompet, S., Uitterlinden, A. G., Venturini, C., Vergnaud, A. C., Verweij, N., Vitart, V., Vuckovic, D., Wedenoja, J., Yengo, L., Yu, B., Zhang, W., Zhao, J. H., Boomsma, D. I., Chambers, J., Chasman, D. I., Daniela, T., De Geus, E., Deary, I., Eriksson, J. G., Esko, T., Eulenburg, V., Franco, O. H., Froguel, P., Gieger, C., Grabe, H. J., Gudnason, V., Gyllensten, U., Harris, T. B., Hartikainen, A. L., Heath, A. C., Hocking, L., Hofman, A., Huth, C., Jarvelin, M. R., Jukema, J. W., Kaprio, J., Kooner, J. S., Kutalik, Z., Lahti, J., Langenberg, C., Lehtimäki, T., Liu, Y., Madden, P. A. F., Martin, N., Morrison, A., Penninx, B., Pirastu, N., Psaty, B., Raitakari, O., Ridker, P., Rose, R., Rotter, J. I., Samani, N. J., Schmidt, H., Spector, T. D., Stott, D., Strachan, D., Tzoulaki, I., Van Der Harst, P., Van Duijn, C. M., Marques-Vidal, P., Vollenweider, P., Wareham, N. J., Whitfield, J. B., Wilson, J., Wolffenbuttel, B., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivières, S., Kliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., Dec 13 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

168 Scopus citations

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y. H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A. & Dixit, V. D., Jan 26 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 4, p. 1026-1031 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Albarqi, M. M. Y., Stoltzfus, J. D., Pilgrim, A. A., Nolan, T. J., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Lok, J. B., 2016, In: PLoS pathogens. 12, 1, e1005358.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2015

An opioid-like system regulating feeding behavior in C. Elegans

Cheong, M. C., Artyukhin, A. B., You, Y. J. & Avery, L., Apr 21 2015, In: eLife. 2015, 4, p. 1-19 19 p., e06683.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Bile acids as hormones: The FXR-FGF15/19 pathway

Kliewer, S. A. & Mangelsdorf, D. J., Jun 9 2015, In: Digestive Diseases. 33, 3, p. 327-331 5 p.

Research output: Contribution to journal › Article › peer-review

294 Scopus citations

Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry

Katafuchi, T., Esterházy, D., Lemoff, A., Ding, X., Sondhi, V., Kliewer, S. A., Mirzaei, H. & Mangelsdorf, D. J., Jun 2 2015, In: Cell Metabolism. 21, 6, p. 898-904 7 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop

Patel, R., Bookout, A. L., Magomedova, L., Owen, B. M., Consiglio, G. P., Shimizu, M., Zhang, Y., Mangelsdorf, D. J., Kliewer, S. A. & Cummins, C. L., 2015, In: Molecular Endocrinology. 29, 2, p. 213-223 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Mansuy-Aubert, V., Gautron, L., Lee, S., Bookout, A. L., Kusminski, C. M., Sun, K., Zhang, Y., Scherer, P. E., Mangelsdorf, D. J. & Elmquist, J. K., Jun 15 2015, In: eLife. 4, JUNE, e06667.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Reflections on the field of metabolism

Moller, D. E., Cuervo, A. M. A., Gordon, J., Froguel, P. & Mangelsdorf, D. J., Apr 7 2015, In: Cell Metabolism. 21, 4, p. 505-506 2 p.

Research output: Contribution to journal › Article › peer-review

Starvation-induced collective behavior in C. elegans

Artyukhin, A. B., Yim, J. J., Cheong Cheong, M. & Avery, L., May 27 2015, In: Scientific reports. 5, 10647.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

Wang, Z., Stoltzfus, J., You, Y. J., Ranjit, N., Tang, H., Xie, Y., Lok, J. B., Mangelsdorf, D. J. & Kliewer, S. A., Mar 16 2015, In: PLoS genetics. 11, 3, e1005027.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

2014

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M. & Potthoff, M. J., Dec 1 2014, In: Diabetes. 63, 12, p. 4057-4063 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

443 Scopus citations

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A. & Mangelsdorf, D. J., Oct 7 2014, In: Cell Metabolism. 20, 4, p. 670-677 8 p.

Research output: Contribution to journal › Article › peer-review

376 Scopus citations

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis

Liu, C., Bookout, A. L., Lee, S., Sun, K., Jia, L., Lee, C., Udit, S., Deng, Y., Scherer, P. E., Mangelsdorf, D. J., Gautron, L. & Elmquist, J. K., Apr 1 2014, In: Cell Metabolism. 19, 4, p. 722-730 9 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

SnapShot: Hormones of the gastrointestinal tract

Coate, K. C., Kliewer, S. A. & Mangelsdorf, D. J., Dec 4 2014, In: Cell. 159, 6, p. 1478-1478.e1

Research output: Contribution to journal › Article › peer-review

Structural insights into gene repression by the orphan nuclear receptor SHP

Zhi, X., Zhou, X. E., He, Y., Zechner, C., Suino-Powell, K. M., Kliewer, S. A., Melcher, K., Mangelsdorf, D. J. & Xu, H. E., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 839-844 6 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2013

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

Potthoff, M. J., Potts, A., He, T., Duarte, J. A. G., Taussig, R., Mangelsdorf, D. J., Kliewer, S. A. & Burgess, S. C., Feb 15 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 4, p. G371-G380

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A. & Mangelsdorf, D. J., Sep 2013, In: Nature medicine. 19, 9, p. 1153-1156 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., De Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J. & Kliewer, S. A., Sep 2013, In: Nature medicine. 19, 9, p. 1147-1152 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

406 Scopus citations

Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus

Atkin, S. D., Owen, B. M., Bookout, A. L., Cravo, R. M., Lee, C., Elias, C. F., Elmquist, J. K., Kliewer, S. A. & Mangelsdorf, D. J., Apr 1 2013, In: Molecular Endocrinology. 27, 4, p. 598-605 8 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2012

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., Mangelsdorf, D. J., Kliewer, S. A. & Wan, Y., Feb 21 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3143-3148 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

324 Scopus citations

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J. & Kliewer, S. A., Feb 3 2012, In: Cell. 148, 3, p. 556-567 12 p.

Research output: Contribution to journal › Article › peer-review

450 Scopus citations

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

Zhang, Y., Breevoort, S. R., Angdisen, J., Fu, M., Schmidt, D. R., Holmstrom, S. R., Kliewer, S. A., Mangelsdorf, D. J. & Schulman, I. G., May 1 2012, In: Journal of Clinical Investigation. 122, 5, p. 1688-1699 12 p.

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Pharmacology - Mangelsdorf Lab

Research output

Search results