Pharmacology - Cobb Lab

Research output

Research output per year 1976 1981 1992 1994 1997 1998 1999 2000 2001 2002 2004 2006 2007 2009 2014 2016 2024

• 253 Article
• 27 Review article
• 8 Comment/debate
• 7 Short survey
• 2 More
  • 1 Conference contribution
  • 1 Editorial

Research output per year

Research output per year

Search results

• A comparison of protein synthetic patterns of MDCK cells grown in serum and hormonally defined serum‐free medium

  Jefferson, D. M., Yang, C. P. H., Cobb, M. H. & Scott, W. N., Apr 1985, In: Journal of cellular physiology. 123, 1, p. 126-131 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Madin Darby Canine Kidney Cells 100%
  • Culture Media 55%
  • Cultured Cells 51%
  • Serum 36%
  • Molecular Weight 33%
  1 Scopus citations

• A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

  Robinson, M. J., Stippec, S. A., Goldsmith, E., White, M. A. & Cobb, M. H., Oct 22 1998, In: Current Biology. 8, 21, p. 1141-1152 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • neurites 100%
  • Neuronal Outgrowth 90%
  • mitogen-activated protein kinase 85%
  • Mitogen-Activated Protein Kinases 78%
  • Chemical Transformation 49%
  281 Scopus citations

• Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

  Frost, J. A., Xu, S., Hutchison, M. R., Marcus, S. & Cobb, M. H., 1996, In: Molecular and cellular biology. 16, 7, p. 3707-3713 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • p21-Activated Kinases 100%
  • Monomeric GTP-Binding Proteins 81%
  • Mitogen-Activated Protein Kinases 68%
  • Protein Kinases 64%
  • JNK Mitogen-Activated Protein Kinases 52%
  244 Scopus citations

• Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK

  Dbouk, H. A., Weil, L. M., Perera, G. K. S., Dellinger, M. T., Pearson, G., Brekken, R. A. & Cobb, M. H., Nov 11 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 45, p. 15999-16004 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proline 100%
  • Alanine 95%
  • Protein Kinases 86%
  • Phosphotransferases 72%
  • Endothelial Cells 69%
  49 Scopus citations

• Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy

  Nicol, R. L., Frey, N., Pearson, G., Cobb, M., Richardson, J. & Olson, E. N., Jun 1 2001, In: EMBO Journal. 20, 11, p. 2757-2767 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sarcomeres 100%
  • Cardiomegaly 84%
  • Leukemia Inhibitory Factor 78%
  • Cardiac Myocytes 73%
  • Mitogen-Activated Protein Kinases 38%
  240 Scopus citations

• Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

  Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H. & Goldsmith, E. J., 1997, In: Cell. 90, 5, p. 859-869 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Lip 100%
  • Phosphotransferases 77%
  • Phosphorylation 69%
  • Tyrosine Residue 57%
  • Threonine 56%
  642 Scopus citations

• Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes

  Polverino, A., Frost, J., Yang, P., Hutchison, M., Neiman, A. M., Cobb, M. H. & Marcus, S., Nov 3 1995, In: Journal of Biological Chemistry. 270, 44, p. 26067-26070 4 p.

  Research output: Contribution to journal › Article › peer-review

  • p21-Activated Kinases 100%
  • Mitogen-Activated Protein Kinase 1 78%
  • Cell Extracts 74%
  • Xenopus 73%
  • Mitogen-Activated Protein Kinases 68%
  88 Scopus citations

• Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

  Khoo, S. & Cobb, M. H., May 27 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 11, p. 5599-5604 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitogens 100%
  • Insulin Secretion 98%
  • Protein Kinases 91%
  • Glucose 62%
  • Insulinoma 15%
  136 Scopus citations

• Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest

  Shibuya, E. K., Boulton, T. G., Cobb, M. H. & Ruderman, J. V., Nov 1992, In: EMBO Journal. 11, 11, p. 3963-3975 13 p.

  Research output: Contribution to journal › Article › peer-review

  • P42 100%
  • Mitogen-Activated Protein Kinase 1 77%
  • Cell Cycle Checkpoints 66%
  • Oocytes 63%
  • Phosphotransferases 52%
  152 Scopus citations

• Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

  Zhang, J., Zhang, F., Ebert, D., Cobb, M. H. & Goldsmith, E. J., Mar 1995, In: Structure. 3, 3, p. 299-307 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinases 100%
  • Lip 71%
  • Phosphorylation 69%
  • Glutamic Acid 37%
  • Enzymes 31%
  113 Scopus citations

• ALDOSTERONE‐INDUCED SYNTHESIS OF PROTEINS RELATED TO SODIUM TRANSPORT IN THE TOAD'S URINARY BLADDER

  Scott, W. N., Yang, CP. P., Skipski, I. A., Cobb, M. H., Reich, I. M. & Terry, P. M., Sep 1981, In: Annals of the New York Academy of Sciences. 372, 1, p. 15-29 15 p.

  Research output: Contribution to journal › Article › peer-review
  8 Scopus citations

• Alterations in the labeling of plasma membrane proteins by vasopressin and aldosterone in the toad urinary bladder

  Slatin, S. L., Cobb, M. H. & Scott, W. N., Jan 1 1978, In: Journal of General Physiology. 72, 6, p. No.16

  Research output: Contribution to journal › Article › peer-review

• Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3

  Wauson, E. M., Zaganjor, E. & Cobb, M. H., Mar 2013, In: Autophagy. 9, 3, p. 418-419 2 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors 100%
  • Autophagy 95%
  • Amino Acids 69%
  • Myocardium 20%
  • Membrane Proteins 20%
  31 Scopus citations

• Amino acids regulate mTORC1 by an obligate two-step mechanism

  Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Oct 21 2016, In: Journal of Biological Chemistry. 291, 43, p. 22414-22426 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Amino Acids 55%
  • Acid 27%
  • Aminoacylation 12%
  • L-Asparagine 12%
  53 Scopus citations

• An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

  Boulton, T. G., Yancopoulos, G. D., Gregory, J. S., Slaughter, C., Moomaw, C., Hsu, J. & Cobb, M. H., 1990, In: Science. 249, 4964, p. 64-67 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase 3 100%
  • Cell Cycle Checkpoints 83%
  • Protein Kinases 79%
  • Yeasts 69%
  • Phosphotransferases 66%
  602 Scopus citations

• An insulin-stimulated ribosomal protein S6 kinase from rabbit liver

  Gregory, J. S., Boulton, T. G., Sang, B. C. & Cobb, M. H., 1989, In: Journal of Biological Chemistry. 264, 31, p. 18397-18401 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribosomal Protein S6 Kinases 100%
  • Rabbits 51%
  • Insulin 49%
  • Liver 37%
  • Insulin Derivative 36%
  68 Scopus citations

• An insulin-stimulated ribosomal protein S6 kinase in 3T3-L1 cells

  Cobb, M. H., 1986, In: Journal of Biological Chemistry. 261, 28, p. 12994-12996 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribosomal Protein S6 100%
  • Ribosomal Protein S6 Kinases 92%
  • 3T3-L1 Cells 81%
  • DEAE-Cellulose Chromatography 64%
  • S 6 59%
  51 Scopus citations

• A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum

  Frost, J. A., Geppert, T. D., Cobb, M. H. & Feramisco, J. R., Apr 26 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 9, p. 3844-3848 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • phorbol-12-myristate 100%
  • Transcription Factor AP-1 95%
  • Extracellular Signal-Regulated MAP Kinases 93%
  • Acetates 84%
  • Mitogen-Activated Protein Kinase 3 71%
  210 Scopus citations

• ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

  Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In: Cell Reports. 16, 5, p. 1259-1272 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Tumors 100%
  • Small Cell Lung Carcinoma 98%
  • Heterogeneity 81%
  • Oncogenic 61%
  • Lung 47%
  302 Scopus citations

• ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

  Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E., Minna, J. D. & Vogt, P. K., Oct 14 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenes 100%
  • Lung Neoplasms 83%
  • Non-Small Cell Lung Carcinoma 62%
  • Small Cell Lung Carcinoma 38%
  • Neuroendocrine Cells 22%
  188 Scopus citations

• ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

  Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E. & Minna, J. D., Oct 14 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Oncogenes 100%
  • Lung Neoplasms 83%
  • Non-Small Cell Lung Carcinoma 62%
  • Small Cell Lung Carcinoma 38%
  • Chromatin Immunoprecipitation Sequencing 22%

• A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus

  Cobb, M. H., Burr, J. G., Linder, M. E., Gray, T. B. & Gregory, J. S., Jun 13 1986, In: Biochemical and Biophysical Research Communications. 137, 2, p. 702-708 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribosomal Protein S6 Kinases 100%
  • Rous sarcoma virus 99%
  • 3T3-L1 Cells 87%
  • Chick Embryo 83%
  • Fibroblasts 53%
  8 Scopus citations

• A small molecule differentiation inducer increases insulin production by pancreatic β cells

  Dioum, E. M., Osborne, J. K., Goetsch, S., Russell, J., Schneider, J. W. & Cobb, M. H., Dec 20 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20713-20718 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Isoxazoles 100%
  • Insulin 47%
  • Histones 32%
  • Transferases 23%
  • Histone Deacetylases 13%
  33 Scopus citations

• Assaying protein kinase activity with radiolabeled ATP

  Karra, A. S., Stippec, S. & Cobb, M. H., May 26 2017, In: Journal of Visualized Experiments. 2017, 123, e55504.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pharmacologic Agent 100%
  • Adenosinetriphosphate 89%
  • Assays 80%
  • Protein Kinases 63%
  • Proteins 63%
  11 Scopus citations

• Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

  Zhang, F., Strand, A., Robbins, D., Cobb, M. H. & Goldsmith, E. J., 1994, In: Nature. 367, 6465, p. 704-711 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclic AMP-Dependent Protein Kinases 100%
  • Protein Kinases 88%
  • Tyrosine 88%
  • Phosphotransferases 74%
  • Binding Sites 74%
  562 Scopus citations

• Autophosphorylation activates the soluble cytoplasmic domain of the insulin receptor in an intermolecular reaction

  Cobb, M. H., Sang, B. C., Gonzalez, R., Goldsmith, E. & Ellis, L., 1989, In: Journal of Biological Chemistry. 264, 31, p. 18701-18706 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Insulin Receptor 100%
  • Insulin Derivative 90%
  • Phosphate 57%
  • Enzymes 48%
  • Protamines 48%
  93 Scopus citations

• Bacterial expression of activated mitogen-activated protein kinases

  Wilsbacher, J. L. & Cobb, M. H., 2001, In: Methods in Enzymology. 332, p. 387-400 14 p.

  Research output: Contribution to journal › Article › peer-review
  24 Scopus citations

• Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed rat-1 cells, but not in untransformed cells

  James, G. L., Brown, M. S., Cobb, M. H. & Goldstein, J. L., Nov 4 1994, In: Journal of Biological Chemistry. 269, 44, p. 27705-27714 10 p.

  Research output: Contribution to journal › Article › peer-review

  • BZA 5B 100%
  • Peptidomimetics 67%
  • Peptidomimetic 56%
  • Benzodiazepine 53%
  • Benzodiazepines 47%
  112 Scopus citations

• Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation

  Gallagher, E. D., Xu, S., Moomaw, C., Slaughter, C. A. & Cobb, M. H., Nov 29 2002, In: Journal of Biological Chemistry. 277, 48, p. 45785-45792 8 p.

  Research output: Contribution to journal › Article › peer-review

  • JNK Mitogen-Activated Protein Kinases 100%
  • Heat-Shock Proteins 92%
  • Serine 85%
  • Protein Kinases 81%
  • Phosphorylation 61%
  43 Scopus citations

• Biological cross-talk between WNK1 and the transforming growth factor β-Smad signaling pathway

  Lee, B. H., Chen, W., Stippec, S. & Cobb, M. H., Jun 22 2007, In: Journal of Biological Chemistry. 282, 25, p. 17985-17996 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Small Interfering RNA 100%
  • Transforming Growth Factors 75%
  • Smad2 Protein 41%
  • Threonine 40%
  • Lysine 34%
  46 Scopus citations

• Biosynthetic processes related to the stimulation by insulin of sodium transport in the toad bladder

  Reich, I. M., Brown, J. A. & Cobb, M. H., 1979, In: Bulletin of the New York Academy of Medicine: Journal of Urban Health. 55, 4, p. 401-402 2 p.

  Research output: Contribution to journal › Article › peer-review

• Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback

  Duan, L. & Cobb, M. H., Dec 21 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 51, p. 22314-22319 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Calcineurin 100%
  • Glucose 50%
  • Calcium 31%
  • calcineurin phosphatase 17%
  • Nutrients 9%
  27 Scopus citations

• Casein kinase Iγ subfamily: Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes

  Zhai, L., Graves, P. R., Robinson, L. C., Italiano, M., Culbertson, M. R., Rowles, J., Cobb, M. H., DePaoli-Roach, A. A. & Roach, P. J., May 26 1995, In: Journal of Biological Chemistry. 270, 21, p. 12717-12724 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Casein Kinase I 100%
  • Molecular Cloning 74%
  • Saccharomyces cerevisiae 58%
  • Protein Isoforms 51%
  • Protein 26%
  95 Scopus citations

• Catalytic reaction pathway for the mitogen-activated protein kinase ERK2

  Prowse, C. N., Hagopian, J. C., Cobb, M. H., Ahn, N. G. & Lew, J., May 23 2000, In: Biochemistry. 39, 20, p. 6258-6266 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Myelin Basic Protein 100%
  • Mitogen-Activated Protein Kinases 81%
  • Catalysis 52%
  • Protein 33%
  • Viscosity 29%
  53 Scopus citations

• Cell condition-dependent regulation of ERK5 by cAMP

  Pearson, G. W. & Cobb, M. H., Dec 13 2002, In: Journal of Biological Chemistry. 277, 50, p. 48094-48098 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Myoblasts 100%
  • Forskolin 50%
  • Tyrosine 31%
  • Colforsin 31%
  • Receptor Protein-Tyrosine Kinases 31%
  17 Scopus citations

• Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3

  Cheng, M., Zhen, E., Robinson, M. J., Ebert, D., Goldsmith, E. & Cobb, M. H., 1996, In: Journal of Biological Chemistry. 271, 20, p. 12057-12062 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase 6 100%
  • Protein-Serine-Threonine Kinases 62%
  • Mitogen-Activated Protein Kinases 55%
  • Serine 52%
  • Protein Kinases 34%
  37 Scopus citations

• Characterization of mitogen-activated protein kinase (MAPK) dimers

  Wilsbacher, J. L., Juang, Y. C., Khokhlatchev, A. V., Gallagher, E., Binns, D., Goldsmith, E. J. & Cobb, M. H., Nov 7 2006, In: Biochemistry. 45, 44, p. 13175-13182 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimerization 100%
  • Mitogen-Activated Protein Kinases 87%
  • Protein 36%
  • Divalent Cations 35%
  • Monomer 34%
  26 Scopus citations

• Characterization of OSR1, a Member of the Mammalian Ste20p/Germinal Center Kinase Subfamily

  Chen, W., Yazicioglu, M. & Cobb, M. H., Mar 19 2004, In: Journal of Biological Chemistry. 279, 12, p. 11129-11136 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Germinal Center Kinases 100%
  • JNK Mitogen-Activated Protein Kinases 42%
  • Oxidative Stress 39%
  • Sorbitol 29%
  • Protein 22%
  70 Scopus citations

• Characterization of protein kinase CK2 from Trypanosoma brucei

  Jensen, B. C., Kifer, C. T., Brekken, D. L., Randall, A. C., Wang, Q., Drees, B. L. & Parsons, M., Jan 2007, In: Molecular and Biochemical Parasitology. 151, 1, p. 28-40 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Casein Kinase II 100%
  • Trypanosoma brucei brucei 97%
  • Trypanosoma brucei 92%
  • Polyamines 88%
  • Guanosine Triphosphate 78%
  58 Scopus citations

• Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils

  Zhang, E. R., Liu, S., Wu, L. F., Altschuler, S. J. & Cobb, M. H., Dec 13 2016, In: Science signaling. 9, 458, ra122.

  Research output: Contribution to journal › Article › peer-review

  • Chemoattractant 100%
  • methionyl-leucyl-phenylalanine 96%
  • Chemotactic Factors 76%
  • Neutrophils 53%
  • Phosphotransferases 52%
  22 Scopus citations

• Chloride sensing by WNK1 involves inhibition of autophosphorylation

  Piala, A. T., Moon, T. M., Akella, R., He, H., Cobb, M. H. & Goldsmith, E. J., May 6 2014, In: Science signaling. 7, 324, ra41.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chlorides 100%
  • Chloride 54%
  • Sodium Chloride 35%
  • Potassium Chloride 26%
  • Phosphotransferases 24%
  285 Scopus citations

• Cholesterol Regulates the Tumor Adaptive Resistance to MAPK Pathway Inhibition

  Wang, X. D., Kim, C., Zhang, Y., Rindhe, S., Cobb, M. H. & Yu, Y., Dec 3 2021, In: Journal of Proteome Research. 20, 12, p. 5379-5391 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pathway Inhibitor 100%
  • Cholesterol 72%
  • Resistance 50%
  • Mutation 34%
  • Anticholesteremic Agent 30%
  4 Scopus citations

• Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in β-cells

  Lawrence, M. C., McGlynn, K., Shao, C., Duan, L., Naziruddin, B., Levy, M. F. & Cobb, M. H., Sep 9 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 36, p. 13315-13320 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinases 100%
  • Chromatin 89%
  • Insulin 51%
  • Glucose 47%
  • Genes 40%
  60 Scopus citations

• Chromomycin A₂ potently inhibits glucosestimulated insulin secretion from pancreatic β cells

  Kalwat, M. A., Hwang, I. H., Macho, J., Grzemska, M. G., Yang, J. Z., McGlynn, K., MacMillan, J. B. & Cobb, M. H., Dec 1 2018, In: Journal of General Physiology. 150, 12, p. 1747-1757 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chromomycin A2 100%
  • Insulin Secretion 43%
  • Plicamycin 19%
  • Glucose 9%
  • Insulin 8%
  5 Scopus citations

• c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

  Minden, A., Lin, A., Smeal, T., Dérijard, B., Cobb, M., Davis, R. & Karin, M., Oct 1994, In: Molecular and cellular biology. 14, 10, p. 6683-6688 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitogen-Activated Protein Kinases 100%
  • Transcription Factor AP-1 74%
  • Phosphorylation 69%
  • Intercellular Signaling Peptides and Proteins 27%
  • Cytokines 20%
  451 Scopus citations

• C-kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas

  Funasaka, Y., Boulton, T., Cobb, M., Yarden, Y., Fan, B., Lyman, S. D., Williams, D. E., Anderson, D. M., Zakut, R., Mishima, Y. & Halaban, R., 1992, In: Molecular biology of the cell. 3, 2, p. 197-209 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell Factor 100%
  • Melanocytes 93%
  • Mitogen-Activated Protein Kinases 81%
  • Tyrosine 76%
  • Melanoma 68%
  188 Scopus citations

• Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

  Xu, S., Robbins, D. J., Christerson, L. B., English, J. M., Vanderbilt, C. A. & Cobb, M. H., May 28 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 11, p. 5291-5295 5 p.

  Research output: Contribution to journal › Article › peer-review

  • MAP Kinase Kinase Kinase 1 100%
  • Organism Cloning 55%
  • Complementary DNA 48%
  • Membranes 35%
  • Proteins 22%
  122 Scopus citations

• Comparative crystallography of map kin a se/inhibitor complexes reveals origin of selectivity of pyridinylimidazoie compounds and olomoucine

  Wane, Z., J-Canagaraiah, B., Adams, J. L., Young, P. R., Cobb, M. H. & Goldsmith, E. J., 1998, In: FASEB Journal. 12, 8, p. A1301

  Research output: Contribution to journal › Article › peer-review

  • olomoucine 100%
  • Kin 92%
  • EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 90%
  • Crystallography 81%
  • Catalytic Domain 50%

• Context-dependent regulation of NeuroD activity and protein accumulation

  Dufton, C., Marcora, E., Chae, J. H., McCullough, J., Eby, J., Hausburg, M., Stein, G. H., Khoo, S., Cobb, M. H. & Lee, J. E., Apr 2005, In: Molecular and Cellular Neuroscience. 28, 4, p. 727-736 10 p.

  Research output: Contribution to journal › Article › peer-review

  • NeuroD protein 100%
  • Xenopus 52%
  • Insulin-Secreting Cells 31%
  • Embryonic Structures 24%
  • Alanine 20%
  12 Scopus citations

• Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

  English, J. M., Pearson, G., Hockenberry, T., Shivakumar, L., White, M. A. & Cobb, M. H., Oct 29 1999, In: Journal of Biological Chemistry. 274, 44, p. 31588-31592 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Signal Transduction 100%
  • Mitogen-Activated Protein Kinase 7 77%
  • NIH 3T3 Cells 59%
  • Chemical Transformation 58%
  • Growth 46%
  107 Scopus citations