Pediatric Residency

Research output

Research output per year 1994 2019 2020 2021 2022 2023 2024

• 241 Article
• 22 Review article
• 12 Comment/debate
• 10 Letter
• 22 More
  • 9 Chapter
  • 9 Editorial
  • 3 Short survey
  • 1 Conference article

Research output per year

Research output per year

Search results

• 2024

  CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway

  Hernandez, K. C., Shah, A. M., Lopez, V. A., Tagliabracci, V. S., Chen, K., Xu, L., Bassel-Duby, R., Olson, E. N. & Liu, N., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 4, e2315925121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rhabdomyosarcoma 100%
  • Growth 42%
  • Adenosine A2 Receptor Agonists 27%
  • ectoATPase 24%
  • Adenosine Monophosphate 18%

• Contribution of caregiver and child anxiety and depressive symptoms to child asthma-related quality of life

  Gwak, D. Y., Tea, J. C., Fatima, F. N., Palka, J. M., Lehman, H., Khan, D. A., Zhou, H., Wood, B. L., Miller, B. D. & Brown, E. S., 2024, (Accepted/In press) In: Annals of Allergy, Asthma and Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Caregivers 100%
  • Asthma 90%
  • Anxiety 83%
  • Depression 76%
  • Quality of Life 75%

• CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model

  Lebek, S., Caravia, X. M., Straub, L. G., Alzhanov, D., Tan, W., Li, H., McAnally, J. R., Chen, K., Xu, L., Scherer, P. E., Liu, N., Bassel-Duby, R. & Olson, E. N., Jan 20 2024, In: Journal of Clinical Investigation. 134, 1, e175164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 90%
  • Reperfusion Injury 30%
  • Dependovirus 19%
  • Human Genome 16%
  1 Scopus citations

• CVID-Associated Intestinal Disorders in the USIDNET Registry: An Analysis of Disease Manifestations, Functional Status, Comorbidities, and Treatment

  Franzblau, L. E., Fuleihan, R. L., Cunningham-Rundles, C. & Wysocki, C. A., Jan 2024, In: Journal of Clinical Immunology. 44, 1, 32.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Common Variable Immunodeficiency 100%
  • Registries 56%
  • Comorbidity 56%
  • Lymphoma 13%
  • Therapeutics 11%

• Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis

  Liang, P., Zhang, Y., Wan, Y. C. S., Ma, S., Dong, P., Lowry, A. J., Francis, S. J., Khandelwal, S., Delahunty, M., Telen, M. J., Strouse, J. J., Arepally, G. M. & Yang, H., Jan 25 2024, In: Blood. 143, 4, p. 357-369 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hereditary Xerocytosis 100%
  • Erythrocytes 40%
  • Red 35%
  • Phosphatidylserines 34%
  • Phospholipid Transfer Proteins 33%
  1 Scopus citations

• Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila

  Zhang, S., Wu, S., Yao, R., Wei, X., Ohlstein, B. & Guo, Z., Jan 8 2024, In: Developmental cell. 59, 1, p. 125-140.e12

  Research output: Contribution to journal › Article › peer-review

  • Ecdysteroids 100%
  • Ecdysone 97%
  • Abdominal Oblique Muscles 93%
  • Ecdysteroid 92%
  • Asymmetric Cell Division 90%

• Granular Insights: Neutrophil Predominance and Elastase Release in Severe Asthma Exacerbations in a Pediatric Cohort

  Henley, K., Tresselt, E., Hook, J. S., Patel, P. A., Gill, M. A. & Moreland, J. G., Mar 2024, In: Cells. 13, 6, 533.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukocyte Elastase 100%
  • Cell Surface Marker 64%
  • Asthma 60%
  • Donor 52%
  • Granulocytes 51%

• Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

  Deja, S., Fletcher, J., Kim, C-W., Kucejova, B., Fu, X., Mizerska, M., Villegas, M., Pudelko-Malik, N., Browder, N., Inigo-Vollmer, M., Menezes, C. J., Mishra, P., Berglund, E. D., Browning, J. D., Thyfault, J. P., Young, J. D., Horton, J. D. & Burgess, S. C., 2024, (Accepted/In press) In: Cell Metabolism.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Malonyl Coenzyme A 100%
  • Acetyl-CoA Carboxylase 89%
  • Gluconeogenesis 80%
  • Pyruvic Acid 71%
  • Fats 49%

• Metabolic signatures of thymomas: potential biomarkers and treatment targets

  Miller, J. W., Faubert, B. M., Mathews, T. P., Waters, J. K., DeBerardinis, R. J. & Kernstine, K. H., Feb 1 2024, In: European Journal of Cardio-thoracic Surgery. 65, 2, ezad394.

  Research output: Contribution to journal › Article › peer-review

  • Thymoma 100%
  • Biomarkers 53%
  • Glucose 28%
  • Thymus Gland 26%
  • Lactic Acid 24%
  1 Scopus citations

• Quantifying neutrophil extracellular trap release in a combined infection-inflammation NET-array device

  Datla, U. S., Vundurthy, B., Hook, J. S., Menon, N., Razmi Bagtash, H., Shihabeddin, T., Schmidtke, D. W., Moreland, J. G., Radic, M. Z. & Jones, C. N., Jan 4 2024, In: Lab on a Chip. 24, 3, p. 615-628 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukotriene B4 100%
  • Extracellular Traps 98%
  • Histone 75%
  • Immunoassay 66%
  • Biological Marker 63%

• Severe Multiple Drug Intolerance Syndrome in Fibromyalgia and Irritable Bowel Syndrome

  Alvarez, A. A., Palka, J. M. & Khan, D. A., 2024, (Accepted/In press) In: Journal of Allergy and Clinical Immunology: In Practice.

  Research output: Contribution to journal › Article › peer-review

  • Fibromyalgia 100%
  • Irritable Bowel Syndrome 96%
  • Pharmaceutical Preparations 35%
  • Polypharmacy 9%
  • Opiate Alkaloids 8%
• 2023

  Ablation of CaMKIId oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease

  Lebek, S., Chemello, F., Caravia, X. M., Tan, W., Li, H., Chen, K., Xu, L., Liu, N., Bassel-Duby, R. & Olson, E. N., Jan 13 2023, In: Science. 379, 6628, p. 179-185 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Editing 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 93%
  • Heart Diseases 66%
  • Induced Pluripotent Stem Cells 30%
  • Mutation 30%
  34 Scopus citations

• A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut

  Wu, S., Tang, R., Ohlstein, B. & Guo, Z., Dec 15 2023, In: STAR Protocols. 4, 4, 102749.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • caN protocol 100%
  • Drosophila melanogaster 88%
  • Intestinal Mucosa 85%
  • Cell Division 76%
  • Drosophila 75%

• Association Between Disrupted Cerebral Autoregulation and Radiographic Neurologic Injury for Children on Extracorporeal Membrane Oxygenation: A Prospective Pilot Study

  Sanford, E. L., Akorede, R., Miller, I., Morriss, M. C., Nandy, K., Raman, L. & Busch, D. R., Jul 1 2023, In: ASAIO Journal. 69, 7, p. E315-E321

  Research output: Contribution to journal › Article › peer-review

  • Oxygenation 100%
  • Nervous System Trauma 85%
  • Correlation Spectroscopy 85%
  • Extracorporeal Membrane Oxygenation 82%
  • Spectroscopy 77%
  1 Scopus citations

• Association between preoperative respiratory symptoms and perioperative respiratory adverse events in pediatric patients with positive viral testing

  Saynhalath, R., Efune, P. N., Nakonezny, P. A., Alex, G., Sabers, J. N., Clintsman, L. M., Poppino, K. F., Szmuk, P. & Sanford, E. L., Nov 2023, In: Journal of Clinical Anesthesia. 90, 111241.

  Research output: Contribution to journal › Article › peer-review

  • Pediatrics 100%
  • SARS Virus 68%
  • Child 67%
  • Respiratory Tract Infections 28%
  • Anesthetics 27%

• Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice

  Chai, A. C., Cui, M., Chemello, F., Li, H., Chen, K., Tan, W., Atmanli, A., McAnally, J. R., Zhang, Y., Xu, L., Liu, N., Bassel-Duby, R. & Olson, E. N., Feb 2023, In: Nature medicine. 29, 2, p. 401-411 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypertrophic Cardiomyopathy 100%
  • Cardiac Myocytes 81%
  • Adenine 81%
  • Thickening 54%
  • Heart Diseases 35%
  42 Scopus citations

• Biallelic variants in NUDCD2 associated with a multiple malformation syndrome with cholestasis and renal failure

  Scheuerle, A. E., Ni, M., Ahmad, A. A., Timmons, C. F., Rakheja, D., Gordon, E. E. & Boothe, M., Sep 2023, In: American Journal of Medical Genetics, Part A. 191, 9, p. 2324-2328 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cholestasis 100%
  • Renal Insufficiency 77%
  • Ciliopathies 32%
  • Proteins 32%
  • cohesins 31%
  1 Scopus citations

• Clinical Phenotypes of Immediate First-Dose Reactions to mRNA COVID-19: A Multicenter Latent Class Analysis

  Stone, C. A., Robinson, L. B., Li, L., Krantz, M. S., Kwah, J. H., Ortega, G., Mancini, C., Wolfson, A. R., Saff, R. R., Samarakoon, U., Hong, D. I., Koo, G., Chow, T. G., Gruchalla, R., Liao, J. X., Kuster, J. K., Price, C., Ahola, C., Khan, D. A., Phillips, E. J., & 2 othersBanerji, A. & Blumenthal, K. G., Feb 2023, In: Journal of Allergy and Clinical Immunology: In Practice. 11, 2, p. 458-465.e1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus 100%
  • Latent Class Analysis 89%
  • Phenotype 47%
  • Messenger RNA 45%
  • Vaccines 29%
  2 Scopus citations

• Comprehensive characterization of patient-derived xenograft models of pediatric leukemia

  Rogojina, A., Klesse, L. J., Butler, E., Kim, J., Zhang, H., Xiao, X., Guo, L., Zhou, Q., Hartshorne, T., Garcia, D., Weldon, K., Holland, T., Bandyopadhyay, A., Prado, L. P., Wang, S., Yang, D. M., Langevan, A. M., Zou, Y., Grimes, A. C., Assanasen, C., & 10 othersGidvani-Diaz, V., Zheng, S., Lai, Z., Chen, Y., Xie, Y., Tomlinson, G. E., Skapek, S. X., Kurmasheva, R. T., Houghton, P. J. & Xu, L., Nov 17 2023, In: iScience. 26, 11, 108171.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heterografts 100%
  • Leukemia 91%
  • Pediatrics 71%
  • Hispanic Americans 23%
  • Methylation 22%

• Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

  Cai, F., Bezwada, D., Cai, L., Mahar, R., Wu, Z., Chang, M. C., Pachnis, P., Yang, C., Kelekar, S., Gu, W., Brooks, B., Ko, B., Vu, H. S., Mathews, T. P., Zacharias, L. G., Martin-Sandoval, M., Do, D., Oaxaca, K. C., Jin, E. S., Margulis, V., & 3 othersMalloy, C. R., Merritt, M. E. & DeBerardinis, R. J., Oct 3 2023, In: Cell Metabolism. 35, 10, p. 1830-1843.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aspartic Acid 100%
  • Mass Spectrometry 86%
  • Glutamic Acid 84%
  • Magnetic Resonance Spectroscopy 64%
  • Isotope Labeling 56%

• Computed Tomography Is Predictive of Significant Neurologic Injury in Children Supported on Extracorporeal Membrane Oxygenation

  Custer, C., Singh, S., Sanford, E., Nandy, K., Raman, L., Busch, D. R. & Morriss, M. C., Nov 1 2023, In: ASAIO Journal. 69, 11, p. E460-E462

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report

  Pandurangi, S., Kim, S., Asai, A., Bondoc, A., Balistreri, W., Campbell, K., Miethke, A., Peters, A., Rogers, M., Taylor, A., Attia, S. L., Gibbons, T., Mullapudi, B., Sheridan, R., Tiao, G. & Bezerra, J. A., Aug 2023, In: Journal of Pediatric Surgery. 58, 8, p. 1483-1488 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatic Portoenterostomy 100%
  • Biliary Atresia 80%
  • Bile 60%
  • Drainage 51%
  • Adrenal Cortex Hormones 19%
  2 Scopus citations

• Delabeling penicillin allergy in a pediatric primary care clinic

  Chow, T. G., Patel, G., Mohammed, M., Johnson, D. & Khan, D. A., May 2023, In: Annals of Allergy, Asthma and Immunology. 130, 5, p. 667-669 3 p.

  Research output: Contribution to journal › Article › peer-review
  7 Scopus citations

• Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance

  Lyu, J., Liu, Y., Gong, L., Chen, M., Madanat, Y. F., Zhang, Y., Cai, F., Gu, Z., Cao, H., Kaphle, P., Kim, Y. J., Kalkan, F. N., Stephens, H., Dickerson, K. E., Ni, M., Chen, W., Patel, P., Mims, A. S., Borate, U., Burd, A., & 8 othersCai, S. F., Yin, C. C., You, M. J., Chung, S. S., Collins, R. H., DeBerardinis, R. J., Liu, X. & Xu, J., Jan 9 2023, In: Cancer discovery. 13, 1, p. 170-193 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Acute Myeloid Leukemia 73%
  • NADP 55%
  • Leukemia 41%
  • Amino Acids 35%
  5 Scopus citations

• Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture

  Wei, Y., Zhang, E., Yu, L., Ci, B., Sakurai, M., Guo, L., Zhang, X., Lin, S., Takii, S., Liu, L., Liu, J., Schmitz, D. A., Su, T., Zhang, J., Shen, Q., Ding, Y., Zhan, L., Sun, H. X., Zheng, C., Xu, L., & 4 othersOkamura, D., Ji, W., Tan, T. & Wu, J., Dec 21 2023, In: Cell. 186, 26, p. 5859-5875.e24

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Growth Inhibition 100%
  • Embryonic Stem Cells 89%
  • Coculture Techniques 83%
  • Cell Culture Techniques 63%
  • Stem Cells 61%
  4 Scopus citations

• Drug Allergy Practice Parameter Updates to Incorporate Into Your Clinical Practice

  Banerji, A., Solensky, R., Phillips, E. J. & Khan, D. A., Feb 2023, In: Journal of Allergy and Clinical Immunology: In Practice. 11, 2, p. 356-368.e5

  Research output: Contribution to journal › Article › peer-review

  • Drug Hypersensitivity 100%
  • Hypersensitivity 35%
  • Penicillins 32%
  • Delayed Hypersensitivity 24%
  • Biological Products 21%
  5 Scopus citations

• Ectopic PLAG1 induces muscular dystrophy in the mouse

  Aguayo, J. S., Shelton, J. M., Tan, W., Rakheja, D., Cai, C., Shalaby, A., Lee, J., Iannaccone, S. T., Xu, L., Chen, K., Burns, D. K. & Zheng, Y., Jul 12 2023, In: Biochemical and Biophysical Research Communications. 665, p. 159-168 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscular Dystrophies 100%
  • Mutation 71%
  • Skeletal Muscle 55%
  • Dystrophin 52%
  • Lethal 50%
  1 Scopus citations

• Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice

  Lebek, S., Caravia, X. M., Chemello, F., Tan, W., McAnally, J. R., Chen, K., Xu, L., Liu, N., Bassel-Duby, R. & Olson, E. N., Nov 7 2023, In: Circulation. 148, 19, p. 1490-1504 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 90%
  • Heart Failure 57%
  • Constriction 27%
  • Cardiac Myocytes 19%
  3 Scopus citations

• Endothelial and Leptin Receptor⁺ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow

  Kara, N., Xue, Y., Zhao, Z., Murphy, M. M., Comazzetto, S., Lesser, A., Du, L. & Morrison, S. J., Mar 13 2023, In: Developmental cell. 58, 5, p. 348-360.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leptin 100%
  • RNA Sequencing 97%
  • Leptin Receptors 75%
  • Hematopoiesis 63%
  • Endothelial Cells 43%
  10 Scopus citations

• Evaluation of an association between RANKL and OPG with bone disease in people with cystic fibrosis

  Abid, S., Lee, M. J., Rodich, B., Hook, J. S., Moreland, J. G., Towler, D., Maalouf, N. M., Keller, A., Ratti, G. & Jain, R., Jan 2023, In: Journal of Cystic Fibrosis. 22, 1, p. 140-145 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Diseases 100%
  • Cystic Fibrosis 87%
  • Bone Remodeling 16%
  • RANK Ligand 10%
  • Bone and Bones 9%
  1 Scopus citations

• Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan

  Ahmed, S., Akbar, F., Deberardinis, R. J., Ni, M. & Afroze, B., Aug 1 2023, In: Journal of Pediatric Endocrinology and Metabolism. 36, 8, p. 761-771 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylenetetrahydrofolate Reductase (NADPH2) 100%
  • Pakistan 87%
  • Molecular Biology 62%
  • Methylenetetrahydrofolate reductase deficiency 19%
  • Betaine 15%

• Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice

  Lee, S., Schleer, H., Park, H., Jang, E., Boyer, M., Tao, B., Gamez-Mendez, A., Singh, A., Folta-Stogniew, E., Zhang, X., Qin, L., Xiao, X., Xu, L., Zhang, J., Hu, X., Pashos, E., Tellides, G., Shaul, P. W., Lee, W. L., Fernandez-Hernando, C., & 2 othersEichmann, A. & Sessa, W. C., May 2023, In: Nature Cardiovascular Research. 2, 5, p. 438-448 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcytosis 100%
  • LDL Lipoproteins 76%
  • Neutralization 75%
  • Atherosclerosis 60%
  • Activin Receptors 56%
  4 Scopus citations

• Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer

  He, F., Bandyopadhyay, A. M., Klesse, L. J., Rogojina, A., Chun, S. H., Butler, E., Hartshorne, T., Holland, T., Garcia, D., Weldon, K., Prado, L. N. P., Langevin, A. M., Grimes, A. C., Sugalski, A., Shah, S., Assanasen, C., Lai, Z., Zou, Y., Kurmashev, D., Xu, L., & 8 othersXie, Y., Chen, Y., Wang, X., Tomlinson, G. E., Skapek, S. X., Houghton, P. J., Kurmasheva, R. T. & Zheng, S., Dec 2023, In: Nature communications. 14, 1, 7600.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tumors 100%
  • cancer 97%
  • Heterogeneity 96%
  • Antitumor 96%
  • Heterografts 94%

• Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells

  Ikeda, M., Kato, H., Shima, H., Matsumoto, M., Furukawa, E., Yan, Y., Liao, R., Xu, J., Muto, A., Fujiwara, T., Harigae, H., Bresnick, E. H. & Igarashi, K., Feb 2023, In: Experimental Hematology. 118, p. 21-30 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitophagy 100%
  • Erythroid Cells 92%
  • Heme 81%
  • Mitochondria 37%
  • Erythroblasts 35%

• Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle

  Peng, J., Yu, L., Huang, L., Paschoal, V. A., Chu, H., de Souza, C. O., Varre, J. V., Oh, D. Y., Kohler, J. J., Xiao, X., Xu, L., Holland, W. L., Shaul, P. W. & Mineo, C., Dec 2023, In: Molecular Metabolism. 78, 101812.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N-Acetylneuraminic Acid 100%
  • Skeletal Muscle 68%
  • Homeostasis 63%
  • Glucose 54%
  • Liver 44%
  1 Scopus citations

• Hypothermia after extracorporeal cardiopulmonary resuscitation not associated with improved neurologic complications or survival in children: An analysis of the ELSO registry

  Sanford, E. L., Bhaskar, P., Li, X., Thiagarajan, R. & Raman, L., Jul 2023, In: Resuscitation. 188, 109852.

  Research output: Contribution to journal › Article › peer-review

  • Extracorporeal Membrane Oxygenation 100%
  • Cardiopulmonary Resuscitation 93%
  • Hypothermia 88%
  • Organizations 70%
  • Nervous System 68%
  2 Scopus citations

• IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

  Lin, Y. H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M. H., Corbitt, N., Zhang, Y., Sharma, T., Wang, T. & Zhu, H., May 4 2023, In: Cell Stem Cell. 30, 5, p. 665-676.e4

  Research output: Contribution to journal › Article › peer-review

  • Liver Regeneration 100%
  • Hepatocytes 68%
  • Homeostasis 59%
  • 3,5-diethoxycarbonyl-1,4-dihydrocollidine 29%
  • Fasting 26%
  2 Scopus citations

• Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence

  Xu, L., Pierce, J. L., Sanchez, A., Chen, K. S., Shukla, A. A., Fustino, N. J., Stuart, S. H., Bagrodia, A., Xiao, X., Guo, L., Krailo, M. D., Shaikh, F., Billmire, D. F., Pashankar, F., Bestrashniy, J., Oosterhuis, J. W., Gillis, A. J. M., Xie, Y., Teot, L., Mora, J., & 6 othersPoynter, J. N., Rakheja, D., Looijenga, L. H. J., Draper, B. W., Frazier, A. L. & Amatruda, J. F., Dec 2023, In: Nature communications. 14, 1, 2636.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Germ Cell and Embryonal Neoplasms 100%
  • tumors 80%
  • aberration 75%
  • Mutation 71%
  • Molecule 29%
  3 Scopus citations

• Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

  Crossley, J. L., Ostashevskaya-Gohstand, S., Comazzetto, S., Hook, J. S., Guo, L., Vishlaghi, N., Juan, C., Xu, L., Horswill, A. R., Hoxhaj, G., Moreland, J. G., Tower, R. J. & Levi, B., Oct 2023, In: JCI Insight. 8, 20, e169208.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • itaconic acid 100%
  • Neutrophils 43%
  • Inflammation 33%
  • Wounds and Injuries 27%
  • Metabolomics 24%
  3 Scopus citations

• L-2-hydroxyglutaric aciduria – review of literature and case series

  Ahmed, S., Siddiqui, A., DeBerardinis, R. J., Ni, M., Lai, W. G., Cai, F., Vu, H. S. & Afroze, B., Apr 1 2023, In: Annals of Medicine and Surgery. 85, 4, p. 712-717 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-Hydroxyglutaricaciduria 100%
  • alpha-hydroxyglutarate 22%
  • Pakistan 15%
  • Basal Ganglia 14%
  • Siblings 12%
  1 Scopus citations

• Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions

  Kim, Y. J., Lee, M., Lee, Y. T., Jing, J., Sanders, J. T., Botten, G. A., He, L., Lyu, J., Zhang, Y., Mettlen, M., Ly, P., Zhou, Y. & Xu, J., Mar 29 2023, In: Science Advances. 9, 13, eadg1123.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromatin 100%
  • Light 79%
  • Genes 45%
  • Optogenetics 36%
  • Proteomics 26%
  8 Scopus citations

• Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden

  Zhu, M., Kim, J., Deng, Q., Ricciuti, B., Alessi, J. V., Eglenen-Polat, B., Bender, M. E., Huang, H. C., Kowash, R. R., Cuevas, I., Bennett, Z. T., Gao, J., Minna, J. D., Castrillon, D. H., Awad, M. M., Xu, L. & Akbay, E. A., Oct 9 2023, In: Cancer Cell. 41, 10, p. 1731-1748.e8

  Research output: Contribution to journal › Article › peer-review

  • Tumor Burden 100%
  • Lung Neoplasms 83%
  • Immunotherapy 46%
  • Neoplasms 33%
  • DNA-Directed DNA Polymerase 29%
  3 Scopus citations

• Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice

  Yu, L., Xu, L., Chu, H., Peng, J., Sacharidou, A., Hsieh, H. H., Weinstock, A., Khan, S., Ma, L., Durán, J. G. B., McDonald, J., Nelson, E. R., Park, S., McDonnell, D. P., Moore, K. J., Huang, L. J. S., Fisher, E. A., Mineo, C., Huang, L. & Shaul, P. W., Dec 2023, In: Nature communications. 14, 1, 4101.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • estrogens 100%
  • 27-hydroxycholesterol 99%
  • arteriosclerosis 85%
  • macrophages 85%
  • metabolites 78%

• Methyltransferase Inhibition Enables Tgfβ Driven Induction of CDKN2A and B in Cancer Cells

  Liu, Y. T., Romero, C., Xiao, X., Guo, L., Zhou, X., Applebaum, M. A., Xu, L. & Skapek, S. X., 2023, In: Molecular and cellular biology. 43, 3, p. 115-129 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Methyltransferases 100%
  • Rhabdomyosarcoma 63%
  • Neoplasms 28%
  • Clustered Regularly Interspaced Short Palindromic Repeats 20%
  • Neuroblastoma 17%

• Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid

  Frank, A. R., Li, V., Shelton, S. D., Kim, J., Stott, G. M., Neckers, L. M., Xie, Y., Williams, N. S., Mishra, P. & McFadden, D. G., Aug 1 2023, In: Cancer discovery. 13, 8, p. 1884-1903 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fermentation 100%
  • Thyroid Neoplasms 95%
  • Respiration 46%
  • Neoplasms 30%
  • Electron Transport Complex I 25%
  3 Scopus citations

• Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy

  Zhang, Y., Ramirez-Martinez, A., Chen, K., McAnally, J. R., Cai, C., Durbacz, M. Z., Chemello, F., Wang, Z., Xu, L., Bassel-Duby, R., Liu, N. & Olson, E. N., Jul 3 2023, In: Journal of Clinical Investigation. 133, 13, e163333.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Emery-Dreifuss Muscular Dystrophy 100%
  • Mechanical Stress 75%
  • Nuclear Envelope 42%
  • Muscles 37%
  • DNA Damage 32%
  1 Scopus citations

• Neuropsychological assessment in rare pediatric neurogenetic disorders: considerations for cross-cultural clinical research

  Bordes Edgar, V., Dorsman, K. A., Horton, D., Messahel, S. & MacDonald, B., 2023, (Accepted/In press) In: Child Neuropsychology.

  Research output: Contribution to journal › Article › peer-review

  • Research Personnel 100%
  • Pediatrics 92%
  • Health Care Process Assessment 86%
  • Neurodevelopmental Disorders 84%
  • Natural History 72%

• Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

  Li, Y., Hook, J. S., Ding, Q., Xiao, X., Chung, S. S., Mettlen, M., Xu, L., Moreland, J. G. & Agathocleous, M., Dec 2023, In: Nature communications. 14, 1, 2610.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • neutrophils 100%
  • suppressors 93%
  • Extracellular Traps 92%
  • Metabolomics 72%
  • Neutrophils 51%
  5 Scopus citations

• Novel pathogenic UQCRC2 variants in a female with normal neurodevelopment

  Haidar, L. A., Harris, R. C., Pachnis, P., Chen, H., Gotway, G. K., Ni, M. & DeBerardinis, R. J., 2023, In: Cold Spring Harbor Molecular Case Studies. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Core Protein 100%
  • Oxidoreductases 70%
  • Electron Transport Complex III 43%
  • Hyperammonemia 41%
  • Lactic Acidosis 39%
  1 Scopus citations

• Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution

  Dos Santos, M., Shah, A. M., Zhang, Y., Bezprozvannaya, S., Chen, K., Xu, L., Lin, W., McAnally, J. R., Bassel-Duby, R., Liu, N. & Olson, E. N., Dec 2023, In: Nature communications. 14, 1, 4333.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • genes 100%
  • Regulator Genes 88%
  • Muscle Development 66%
  • skeletal muscle 66%
  • Atlases 61%
  2 Scopus citations