Neurology & Neurotherapeutics - NE Neuro Oncology Sections

Research output

Research output per year 1994 2010 2011 2012 2013 2014 2017 2019 2020 2021 2024

• 138 Article
• 7 Comment/debate
• 6 Review article
• 4 Chapter
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles

  Xiong, H., Wilson, B. A., Ge, X., Gao, X., Cai, Q., Xu, X., Bachoo, R. & Qin, Z., Feb 7 2024, In: Nano Letters. 24, 5, p. 1570-1578 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diffusion barriers 100%
  • Plasmonics 99%
  • Diffusion Barrier 85%
  • margins 73%
  • drugs 68%

• Optical Modulation of the Blood–Brain Barrier for Glioblastoma Treatment

  Cai, Q., Fan, H., Li, X., Giannotta, M., Bachoo, R. & Qin, Z., Jan 20 2024, In: Bio-protocol. 14, 2, e4920.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Optical Modulation 100%
  • glioblastoma 93%
  • blood-brain barrier 85%
  • Glioblastoma 63%
  • brain neoplasms 59%
• 2023

  ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma

  Blandin, A. F., Giglio, R., Graham, M. S., Garcia, G., Malinowski, S., Woods, J. K., Ramkissoon, S., Ramkissoon, L., Dubois, F., Schoolcraft, K., Tsai, J., Wang, D., Jones, R., Vogelzang, J., Pelton, K., Becker, S., Watkinson, F., Sinai, C., Cohen, E. F., Booker, M. A., & 26 othersTolstorukov, M. Y., Haemels, V., Goumnerova, L., Wright, K., Kieran, M., Fehnel, K., Reardon, D., Tauziede-Espariat, A., Lulla, R., Carcamo, B., Chaleff, S., Charest, A., De Smet, F., Ligon, A. H., Dubuc, A., Pages, M., Varlet, P., Wen, P. Y., Alexander, B. M., Chi, S., Alexandrescu, S., Kittler, R., Bachoo, R., Bandopadhayay, P., Beroukhim, R. & Ligon, K. L., Jul 2023, In: Clinical Cancer Research. 29, 14, p. 2651-2667 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anaplastic Lymphoma Kinase 100%
  • Glioblastoma 73%
  • Glioma 15%
  • Pediatrics 14%
  • ceritinib 9%
  3 Scopus citations
• 2022

  EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation

  Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., Hatanpaa, K. J., Garzon-Muvdi, T., Koduru, P., Nayab, A., Jenks, J., Sathe, A. A., Liu, Y., Xing, C., Wu, S. Y., Chiang, C. M., Mukherjee, B., Burma, S., Wohlfeld, B., Patel, T., & 10 othersMickey, B., Abdullah, K., Youssef, M., Pan, E., Gerber, D. E., Tian, S., Sarkaria, J. N., McBrayer, S. K., Zhao, D. & Habib, A. A., Aug 2022, In: Nature cell biology. 24, 8, p. 1291-1305 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • ErbB Receptors 96%
  • Oncogenes 96%
  • Up-Regulation 73%
  • Ligands 71%
  12 Scopus citations

• Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas

  Ijare, O. B., Hambarde, S., Brasil Da Costa, F. H., Lopez, S., Sharpe, M. A., Helekar, S. A., Hangel, G., Bogner, W., Widhalm, G., Bachoo, R. M., Baskin, D. S. & Pichumani, K., Apr 1 2022, In: Neuro-oncology. 24, 4, p. 556-568 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Meningioma 100%
  • Glutamine 96%
  • Amino Acids 64%
  • Alanine 31%
  • CB-839 31%
  10 Scopus citations

• Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas

  Hsu, E. J., Thomas, J., Maher, E. A., Youssef, M., Timmerman, R. D., Wardak, Z., Dan, T. D., Patel, T. R. & Vo, D. T., Dec 2022, In: Discover Oncology. 13, 1, 126.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • Survival 56%
  • Radiation 20%
  • Mutation 15%
  • Genetic Markers 9%
  5 Scopus citations

• Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

  Parida, P. K., Marquez-Palencia, M., Nair, V., Kaushik, A. K., Kim, K., Sudderth, J., Quesada-Diaz, E., Cajigas, A., Vemireddy, V., Gonzalez-Ericsson, P. I., Sanders, M. E., Mobley, B. C., Huffman, K., Sahoo, S., Alluri, P., Lewis, C., Peng, Y., Bachoo, R. M., Arteaga, C. L., Hanker, A. B., & 2 othersDeBerardinis, R. J. & Malladi, S., Jan 4 2022, In: Cell Metabolism. 34, 1, p. 90-105.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms 100%
  • Lactic Acid 71%
  • Immunologic Monitoring 69%
  • Breast Neoplasms 68%
  • Acidic Amino Acid Transport Systems 55%
  33 Scopus citations

• Neutrophilia and post-radiation thrombocytopenia predict for poor prognosis in radiation-treated glioma patients

  Hsu, E. J., Thomas, J., Maher, E. A., Youssef, M., Timmerman, R. D., Wardak, Z., Lee, M., Dan, T. D., Patel, T. R. & Vo, D. T., Sep 9 2022, In: Frontiers in Oncology. 12, 1000280.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thrombocytopenia 100%
  • Glioma 97%
  • Radiation 79%
  • Lymphocytes 48%
  • Neutrophils 34%
  6 Scopus citations
• 2021

  Distance traveled to glioblastoma treatment: A measure of the impact of socioeconomic status on survival

  Bird, C. E., Traylor, J. I., Youssef, M. & Abdullah, K., Oct 2021, In: Clinical Neurology and Neurosurgery. 209, 106909.

  Research output: Contribution to journal › Article › peer-review

  • Glioblastoma 100%
  • Social Class 96%
  • Survival 56%
  • Income 20%
  • Therapeutics 16%
  3 Scopus citations

• Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain

  Ahmed, M. S., Wang, P., Nhi Nguyen, N. U., Nakada, Y., Menendez-Montes, I., Ismail, M., Bachoo, R., Henkemeyer, M., Sadek, H. A. & Kandil, E. S., Mar 9 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 10, e2016265118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • EphB1 Receptor 100%
  • Chlortetracycline 75%
  • Demeclocycline 57%
  • Tetracycline 52%
  • Neuralgia 51%
  8 Scopus citations

• IDH mutation status and the development of venous thromboembolism in astrocytoma patients

  Mandel, J. J., Youssef, M., Yust-Katz, S., Patel, A. J., Jalali, A., Li, Z., Wu, J., Ludmir, E. B. & de Groot, J. F., Aug 15 2021, In: Journal of the Neurological Sciences. 427, 117538.

  Research output: Contribution to journal › Article › peer-review

  • Isocitrate Dehydrogenase 100%
  • Astrocytoma 81%
  • Venous Thromboembolism 79%
  • Mutation 41%
  • Biomarkers 11%
  4 Scopus citations

• Preoperative imaging of glioblastoma patients using hyperpolarized ¹³C pyruvate: Potential role in clinical decision making

  Chen, J., Patel, T. R., Pinho, M. C., Choi, C., Harrison, C. E., Baxter, J. D., Derner, K., Pena, S., Liticker, J., Raza, J., Hall, R. G., Reed, G. D., Cai, C., Hatanpaa, K. J., Bankson, J. A., Bachoo, R. M., Malloy, C. R., Mickey, B. E. & Park, J. M., Jan 1 2021, In: Neuro-Oncology Advances. 3, 1, vdab092.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pyruvic Acid 100%
  • Clinical Decision-Making 98%
  • Glioblastoma 92%
  • Neoplasms 30%
  • Lactic Acid 27%
  13 Scopus citations

• Probing Cerebral Metabolism with Hyperpolarized ¹³C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound

  Hackett, E. P., Shah, B. R., Cheng, B., Lague, E., Vemireddy, V., Mendoza, M., Bing, C., Bachoo, R. M., Billingsley, K. L., Chopra, R. & Park, J. M., Aug 4 2021, In: ACS Chemical Neuroscience. 12, 15, p. 2820-2828 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycerate 100%
  • Lactate 63%
  • Blood-Brain Barrier 60%
  • Pyruvate 48%
  • Pharmacological Metabolism 48%
  2 Scopus citations

• Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles

  Li, X., Vemireddy, V., Cai, Q., Xiong, H., Kang, P., Li, X., Giannotta, M., Hayenga, H. N., Pan, E., Sirsi, S. R., Mateo, C., Kleinfeld, D., Greene, C., Campbell, M., Dejana, E., Bachoo, R. & Qin, Z., Nov 24 2021, In: Nano Letters. 21, 22, p. 9805-9815 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Blood-Brain Barrier 100%
  • blood-brain barrier 88%
  • stimulation 56%
  • Nanoparticles 55%
  • Permeability 45%
  43 Scopus citations

• SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides

  Ikeda, Y., Hirayama, A., Kofuji, S., Hirota, Y., Kamata, R., Osaka, N., Fujii, Y., Sasaki, M., Ikeda, S., Smith, E. P., Bachoo, R., Soga, T. & Sasaki, A. T., Dec 1 2021, In: Journal of Biochemistry. 170, 6, p. 699-711 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ribonucleic Acid 100%
  • Stable Isotope 86%
  • Isotopes 85%
  • Nucleotide 64%
  • Metabolic 63%

• Spectral fitting strategy to overcome the overlap between 2-hydroxyglutarate and lipid resonances at 2.25 ppm

  Askari, P., Dimitrov, I. E., Ganji, S. K., Tiwari, V., Levy, M., Patel, T. R., Pan, E., Mickey, B. E., Malloy, C. R., Maher, E. A. & Choi, C., Oct 2021, In: Magnetic resonance in medicine. 86, 4, p. 1818-1828 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-hydroxyglutarate 100%
  • Lipids 40%
  • Isocitrate Dehydrogenase 21%
  • Mutation 5%
  • Brain Neoplasms 4%
  7 Scopus citations
• 2020

  A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE)

  Cloughesy, T. F., Brenner, A., De Groot, J. F., Butowski, N. A., Zach, L., Campian, J. L., Ellingson, B. M., Freedman, L. S., Cohen, Y. C., Lowenton-Spier, N., Rachmilewitz Minei, T., Fain Shmueli, S., Avgeropoulos, N., Beck, J., Benkers, T., Bokstein, F., Brenner, A., Burton, E., Campian, J., Carrillo, J., & 38 othersDe Groot, J., De Robles, P., Drappatz, J., Dunbar, I., Fink, K., Groves, M., Han, X., Adila, H., Jensen, R., Kowalska, A., Kumthekar, P., Lee, M., Lesser, G., Lossos, A., Lukas, R., Macdonald, D., Mammoser, A., Mechtler, L., Mohile, N., Nagpal, S., Nicholas, G., Kreisl, T., Pan, E., Peak, S., Pearlman, M., Perry, J., Peterson, R., Piccioni, D., Robins, H., Ronan, L., Salacz, M., Schiff, D., Tran, D., Zach, L., Tzuk-Shina, T., Walbert, T., Wen, P. Y. & Youst, S., May 15 2020, In: Neuro-oncology. 22, 5, p. 705-717 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bevacizumab 100%
  • Glioblastoma 88%
  • Survival 33%
  • Fever 22%
  • Safety Management 18%
  46 Scopus citations

• ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models

  Vue, T. Y., Kollipara, R. K., Borromeo, M. D., Smith, T., Mashimo, T., Burns, D. K., Bachoo, R. M. & Johnson, J. E., Dec 1 2020, In: GLIA. 68, 12, p. 2613-2630 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cdc Genes 100%
  • Glioblastoma 77%
  • Brain Neoplasms 72%
  • Glioma 72%
  • Transcription Factors 58%
  20 Scopus citations

• Differences in creep response of GBM cells migrating in confinement

  Khan, I., Bui, L., Bachoo, R., Kim, Y. T. & Chuong, C. J., Jan 1 2020, In: International Biomechanics. 7, 1, p. 44-57 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • Creep 86%
  • Energy dissipation 42%
  • Pressure 32%
  • Elastic deformation 28%
  1 Scopus citations

• Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

  Gao, X., Zhang, Z., Mashimo, T., Shen, B., Nyagilo, J., Wang, H., Wang, Y., Liu, Z., Mulgaonkar, A., Hu, X. L., Piccirillo, S. G. M., Eskiocak, U., Davé, D. P., Qin, S., Yang, Y., Sun, X., Fu, Y. X., Zong, H., Sun, W., Bachoo, R. M., & 1 othersGe, W. P., Feb 25 2020, In: Cell Reports. 30, 8, p. 2489-2500.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Vesicles 100%
  • Glioma 78%
  • Communication 77%
  • Brain 41%
  • Reduction 38%
  57 Scopus citations

• Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness

  Vivek, T., Elena, V. D., Kimmo, J. H., Ang, G., Song, Z., Zhongxu, A., Sandeep, K. G., Jack, M. R., Cheryl, M. L., Pegah, A., Jeannie, B., Michael, L., Ivan, D., Binu, P. T., Marco, C. P., Christopher, J. M., Edward, P., Toral, R. P., Ralph, J. D. B., Sherry, A. D., & 4 othersBruce, E. M., Craig, R. M., Elizabeth, A. M. & Changho, C., Jul 1 2020, In: Neuro-oncology. 22, 7, p. 1018-1029 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycine 100%
  • Glioma 91%
  • Magnetic Resonance Spectroscopy 82%
  • alpha-hydroxyglutarate 71%
  • Biomarkers 64%
  32 Scopus citations

• Intrasession reliability of arterial spin-labeled mri–measured noncontrast perfusion in glioblastoma at 3 t

  Zhou, L., Wang, Y., Pinho, M. C., Pan, E., Xi, Y., Maldjian, J. A. & Madhuranthakam, A. J., Jun 2020, In: Tomography. 6, 2, p. 139-147 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • Perfusion 76%
  • Gray Matter 34%
  • Healthy Volunteers 33%
  • Cerebrovascular Circulation 32%
  5 Scopus citations

• In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients

  Tiwari, V., Mashimo, T., An, Z., Vemireddy, V., Piccirillo, S., Askari, P., Hulsey, K. M., Zhang, S., de Graaf, R. A., Patel, T. R., Pan, E., Mickey, B. E., Maher, E. A., Bachoo, R. M. & Choi, C., Sep 1 2020, In: Magnetic resonance in medicine. 84, 3, p. 1152-1160 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-hydroxyglutarate 100%
  • Isocitrate Dehydrogenase 85%
  • Glioma 57%
  • Heterografts 56%
  • Dermatoglyphics 6%
  11 Scopus citations

• Mechanical regulation of glycolysis via cytoskeleton architecture

  Park, J. S., Burckhardt, C. J., Lazcano, R., Solis, L. M., Isogai, T., Li, L., Chen, C. S., Gao, B., Minna, J. D., Bachoo, R., DeBerardinis, R. J. & Danuser, G., Feb 27 2020, In: Nature. 578, 7796, p. 621-626 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycolysis 100%
  • Cytoskeleton 95%
  • Phosphofructokinases 88%
  • Actomyosin 41%
  • Stress Fibers 39%
  300 Scopus citations

• NRG/RTOG 1122: A phase 2, double-blinded, placebo-controlled study of bevacizumab with and without trebananib in patients with recurrent glioblastoma or gliosarcoma

  Lee, E. Q., Zhang, P., Wen, P. Y., Gerstner, E. R., Reardon, D. A., Aldape, K. D., deGroot, J. F., Pan, E., Raizer, J. J., Kim, L. J., Chmura, S. J., Robins, H. I., Connelly, J. M., Battiste, J. D., Villano, J. L., Wagle, N., Merrell, R. T., Wendland, M. M. & Mehta, M. P., Jun 15 2020, In: Cancer. 126, 12, p. 2821-2828 8 p.

  Research output: Contribution to journal › Article › peer-review

  • trebananib 100%
  • Gliosarcoma 79%
  • Bevacizumab 57%
  • Glioblastoma 51%
  • Progression-Free Survival 46%
  19 Scopus citations

• Occurrence of glioma in pregnant patients: An institutional case series and review of the literature

  Singh, P., Mantilla, E., Sewell, J., Hatanpaa, K. J. & Pan, E., Jun 2020, In: Anticancer Research. 40, 6, p. 3453-3457 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioma 100%
  • Pregnancy 35%
  • Astrocytoma 21%
  • Electronic Health Records 10%
  • Glioblastoma 9%
  3 Scopus citations

• Predictors of prognosis of synchronous brain metastases in small-cell lung cancer patients

  Reddy, S. P., Dowell, J. E. & Pan, E., Aug 1 2020, In: Clinical and Experimental Metastasis. 37, 4, p. 531-539 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Small Cell Lung Carcinoma 100%
  • Neoplasm Metastasis 55%
  • Brain 44%
  • Alaska Natives 12%
  • North American Indians 10%
  16 Scopus citations

• Prolonged steroid dependence in adult patients with glioma

  Mantilla, E. C., Abramowitz, J., Dan, T. & Pan, E., Apr 2020, In: Anticancer Research. 40, 4, p. 2059-2064 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioma 100%
  • Adrenal Insufficiency 82%
  • Steroids 80%
  • Glucocorticoids 59%
  • Radiation Exposure 45%
  4 Scopus citations

• Review of rituximab in primary CNS lymphoma

  Singh, P. K. & Pan, E., Mar 15 2020, In: Journal of the Neurological Sciences. 410, 116649.

  Research output: Contribution to journal › Article › peer-review

  • Rituximab 100%
  • Lymphoma 76%
  • Induction Chemotherapy 66%
  • Standard of Care 17%
  • Drug Therapy 10%
  4 Scopus citations
• 2019

  3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo

  An, Z., Tiwari, V., Baxter, J., Levy, M., Hatanpaa, K. J., Pan, E., Maher, E. A., Patel, T. R., Mickey, B. E. & Choi, C., Feb 2019, In: Magnetic resonance in medicine. 81, 2, p. 795-802 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-hydroxyglutarate 100%
  • Glioma 57%
  • Acoustics 11%
  • Noise 10%
  • Echo-Planar Imaging 7%
  9 Scopus citations

• Adult primary peripheral PNET/Ewing’s sarcoma of the cervical and thoracic spine

  Khwaja, R., Mantilla, E., Fink, K. & Pan, E., 2019, In: Anticancer Research. 39, 8, p. 4463-4465 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Primitive Neuroectodermal Tumors 100%
  • Ewing's Sarcoma 91%
  • Spine 58%
  • Thorax 51%
  • Temozolomide 23%
  8 Scopus citations

• An adult patient with rare primary intracranial alveolar rhabdomyosarcoma

  Desai, K. B., Mella, D. & Pan, E., 2019, In: Anticancer Research. 39, 6, p. 3067-3070 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alveolar Rhabdomyosarcoma 100%
  • Central Nervous System 19%
  • Rhabdomyosarcoma 15%
  • Traumatic Brain Injury 13%
  • Hematoma 12%
  4 Scopus citations

• A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma

  Wen, P. Y., Reardon, D. A., Armstrong, T. S., Phuphanich, S., Aiken, R. D., Landolfi, J. C., Curry, W. T., Zhu, J. J., Glantz, M., Peereboom, D. M., Markert, J. M., LaRocca, R., O'Rourke, D. M., Fink, K., Kim, L., Gruber, M., Lesser, G. J., Pan, E., Kesari, S., Muzikansky, A., & 3 othersPinilla, C., Santos, R. G. & Yu, J. S., Oct 1 2019, In: Clinical Cancer Research. 25, 19, p. 5799-5807 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • Dendritic Cells 90%
  • Vaccines 76%
  • Placebos 69%
  • HLA-A2 Antigen 46%
  163 Scopus citations

• Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

  Jakkamsetti, V., Marin-Valencia, I., Ma, Q., Good, L. B., Terrill, T., Rajasekaran, K., Pichumani, K., Khemtong, C., Hooshyar, M. A., Sundarrajan, C., Patel, M. S., Bachoo, R. M., Malloy, C. R. & Pascual, J. M., 2019, In: Science translational medicine. 11, 480, aan0457.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pyruvate Dehydrogenase Complex Deficiency Disease 100%
  • Citric Acid Cycle 58%
  • Glutamic Acid 31%
  • Brain 29%
  • Pyruvic Acid 25%
  44 Scopus citations

• Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma

  Guo, G., Gong, K., Puliyappadamba, V. T., Panchani, N., Pan, E., Mukherjee, B., Damanwalla, Z., Bharia, S., Hatanpaa, K. J., Gerber, D. E., Mickey, B. E., Patel, T. R., Sarkaria, J. N., Zhao, D., Burma, S. & Habib, A. A., Dec 1 2019, In: Neuro-oncology. 21, 12, p. 1529-1539 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Temozolomide 100%
  • Glioblastoma 79%
  • ErbB Receptors 76%
  • Tumor Necrosis Factor-alpha 57%
  • Methyltransferases 49%
  21 Scopus citations

• H3 K27M Mutations in Thalamic Pilocytic Astrocytomas with Anaplasia

  El Ahmadieh, T. Y., Plitt, A., Kafka, B., Aoun, S. G., Raisanen, J. M., Orr, B., Pan, E., Wardak, Z., Nedzi, L. A. & Patel, T. R., Apr 2019, In: World neurosurgery. 124, p. 87-92 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Anaplasia 100%
  • Astrocytoma 73%
  • Mutation 37%
  • Neoplasms 17%
  • Central Nervous System Neoplasms 16%
  7 Scopus citations

• IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

  Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S., & 37 othersBan, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., Aug 1 2019, In: Nature cell biology. 21, 8, p. 1003-1014 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • IMP Dehydrogenase 100%
  • Glioblastoma 61%
  • Carcinogenesis 47%
  • Transfer RNA 27%
  • Guanine Nucleotides 15%
  89 Scopus citations

• Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

  MGTX Study Group, Mar 2019, In: The Lancet Neurology. 18, 3, p. 259-268 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • margatoxin 100%
  • Thymectomy 70%
  • Myasthenia Gravis 63%
  • Prednisone 55%
  • Edrophonium 4%
  133 Scopus citations

• Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high-grade gliomas

  Todorova, P. K., Fletcher-Sananikone, E., Mukherjee, B., Kollipara, R., Vemireddy, V., Xie, X. J., Guida, P. M., Story, M. D., Hatanpaa, K., Habib, A. A., Kittler, R., Bachoo, R., Hromas, R., Floyd, J. R. & Burma, S., 2019, In: Cancer research. 79, 14, p. 3749-3761 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioma 100%
  • DNA Damage 94%
  • Radiation 81%
  • Linear Energy Transfer 45%
  • X-Rays 25%
  24 Scopus citations

• Spinal pleomorphic xanthoastrocytoma With a QKI-RAF1 Fusion

  Daoud, E. V., Wachsmann, M., Richardson, T. E., Mella, D., Pan, E., Schwarzbach, A., Oliver, D. & Hatanpaa, K. J., Jan 1 2019, In: Journal of neuropathology and experimental neurology. 78, 1, p. 10-14 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • MAP Kinase Signaling System 78%
  • LY3009120 77%
  • trametinib 55%
  • Supratentorial Neoplasms 54%
  9 Scopus citations
• 2018

  Adult brainstem gliomas with H3K27M mutation: Radiology, pathology, and prognosis

  Daoud, E. V., Rajaram, V., Cai, C., Oberle, R. J., Martin, G. R., Raisanen, J. M., White, C. L., Foong, C., Mickey, B. E., Pan, E. & Hatanpaa, K. J., Apr 1 2018, In: Journal of neuropathology and experimental neurology. 77, 4, p. 302-311 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiology 100%
  • Glioma 92%
  • Brain Stem 90%
  • Pathology 63%
  • Mutation 56%
  63 Scopus citations

• Brainstem glioblastoma multiforme in a patient with NF1

  Fortunato, J. T., Reys, B., Singh, P. & Pan, E., Aug 2018, In: Anticancer Research. 38, 8, p. 4897-4900 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurofibromatosis 1 100%
  • Glioblastoma 80%
  • Brain Stem 73%
  • Neurofibromatosis 1 Genes 25%
  • Nonsense Codon 18%
  8 Scopus citations

• Echo-planar spectroscopic imaging with dual-readout alternated gradients (DRAG-EPSI) at 7 T: Application for 2-hydroxyglutarate imaging in glioma patients

  An, Z., Tiwari, V., Ganji, S. K., Baxter, J., Levy, M., Pinho, M. C., Pan, E., Maher, E. A., Patel, T. R., Mickey, B. E. & Choi, C., Apr 2018, In: Magnetic resonance in medicine. 79, 4, p. 1851-1861 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-hydroxyglutarate 100%
  • Echo-Planar Imaging 85%
  • Glioma 57%
  • Isocitrate Dehydrogenase 31%
  • Glioblastoma 7%
  26 Scopus citations

• Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

  Courtney, K. D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy, V., Funk, A. M., Wimberly, J., McNeil, S. S., Kapur, P., Lotan, Y., Margulis, V., Cadeddu, J. A., Pedrosa, I., DeBerardinis, R. J., Malloy, C. R., Bachoo, R. & Maher, E. A., Nov 6 2018, In: Cell Metabolism. 28, 5, p. 793-800.e2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isotopes 100%
  • Renal Cell Carcinoma 89%
  • Citric Acid Cycle 63%
  • Glucose 58%
  • Neoplasms 26%
  172 Scopus citations

• Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression

  Hansen, M. R., Pan, E., Wilson, A., McCreary, M., Wang, Y., Stanley, T., Pinho, M. C., Guo, X. & Okuda, D. T., Sep 1 2018, In: Journal of Neuro-Oncology. 139, 3, p. 731-738 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gadolinium 100%
  • Glioblastoma 90%
  • Neoplasms 29%
  • Principal Component Analysis 19%
  • Health Personnel 15%
  13 Scopus citations

• PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation: A Randomized Phase II Study: BrUOG 244

  Elinzano, H., Glantz, M., Mrugala, M., Kesari, S., Piccioni, D. E., Kim, L., Pan, E., Yunus, S., Coyle, T., Timothy, K., Evans, D., Mantripragada, K., Boxerman, J., DiPetrillo, T., Donahue, J. E., Hebda, N., Mitchell, K. M., Rosati, K. L. & Safran, H., 2018, In: American Journal of Clinical Oncology: Cancer Clinical Trials. 41, 2, p. 159-162 4 p.

  Research output: Contribution to journal › Article › peer-review

  • paclitaxel poliglumex 100%
  • Methyltransferases 57%
  • DNA Methylation 50%
  • Glioblastoma 50%
  • Radiation 38%
  12 Scopus citations

• Successful Novel Treatment of a Paraspinal Primitive Neuroectodermal Tumor with Predominantly Glial Differentiation: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide

  El Ahmadieh, T. Y., Raisanen, J. M., Botros, J., Kabangu, J. L., Pan, E. & Gluf, W., Nov 1 2018, In: World Neurosurgery. 119, p. 340-344 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Primitive Neuroectodermal Tumors 100%
  • Temozolomide 93%
  • Neuroglia 66%
  • Radiotherapy 52%
  • Peripheral Primitive Neuroectodermal Tumors 39%
• 2017

  A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma

  Guo, G., Gong, K., Ali, S., Ali, N., Shallwani, S., Hatanpaa, K. J., Pan, E., Mickey, B., Burma, S., Wang, D. H., Kesari, S., Sarkaria, J. N., Zhao, D. & Habib, A. A., Aug 1 2017, In: Nature neuroscience. 20, 8, p. 1074-1084 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • JNK Mitogen-Activated Protein Kinases 100%
  • Extracellular Signal-Regulated MAP Kinases 96%
  • Glioblastoma 87%
  • ErbB Receptors 84%
  • Tumor Necrosis Factor-alpha 63%
  79 Scopus citations

• Detection of 2-hydroxyglutarate in brain tumors by triple-refocusing MR spectroscopy at 3T in vivo

  An, Z., Ganji, S. K., Tiwari, V., Pinho, M. C., Patel, T., Barnett, S., Pan, E., Mickey, B. E., Maher, E. A. & Choi, C., Jul 2017, In: Magnetic resonance in medicine. 78, 1, p. 40-48 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-hydroxyglutarate 100%
  • Brain Neoplasms 58%
  • Magnetic Resonance Spectroscopy 52%
  • Glutamine 19%
  • Glutamic Acid 16%
  25 Scopus citations

• Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

  Newman, J. P., Wang, G. Y., Arima, K., Guan, S. P., Waters, M. R., Cavenee, W. K., Pan, E., Aliwarga, E., Chong, S. T., Kok, C. Y. L., Endaya, B. B., Habib, A. A., Horibe, T., Ng, W. H., Ho, I. A. W., Hui, K. M., Kordula, T. & Lam, P. Y. P., Dec 1 2017, In: Nature communications. 8, 1, 1913.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-13 Receptor alpha2 Subunit 100%
  • interleukins 78%
  • Interleukin-13 Receptors 75%
  • epidermal growth factor receptor VIII 75%
  • Glioblastoma 46%
  58 Scopus citations