Microbiology - Conrad Lab

Research output

Research output per year 1995 1995 1999 2006 2012 2013 2014 2015 2017 2018 2022

• 33 Article
• 3 Chapter
• 1 Review article

Research output per year

Research output per year

Search results

• Article

  A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

  Park, S. K., Zhou, X., Pendleton, K. E., Hunter, O. V., Kohler, J. J., O'Donnell-Mendell, K. A. & Conrad, N. K., Aug 1 2017, In: Cell Reports. 20, 5, p. 1088-1099 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • O-GlcNAc transferase 100%
  • hexosaminidase C 69%
  • Introns 59%
  • Homeostasis 45%
  • Agar 33%
  72 Scopus citations

• ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins

  Anantharaman, A., Tripathi, V., Khan, A., Yoon, J. H., Singh, D. K., Gholamalamdari, O., Guang, S., Ohlson, J., Wahlstedt, H., Öhman, M., Jantsch, M. F., Conrad, N. K., Ma, J., Gorospe, M., Prasanth, S. G. & Prasanth, K. V., Apr 20 2017, In: Nucleic acids research. 45, 7, p. 4189-4201 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nuclear RNA 100%
  • RNA-Binding Proteins 85%
  • RNA Stability 81%
  • RNA 25%
  • poly(A)-specific ribonuclease 23%
  39 Scopus citations

• A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts

  Conrad, N. K. & Steitz, J. A., May 18 2005, In: EMBO Journal. 24, 10, p. 1831-1841 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Globins 100%
  • Kaposi's Sarcoma 93%
  • RNA Viruses 90%
  • messenger ribonucleoprotein 81%
  • Nuclear RNA 71%
  96 Scopus citations

• A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II

  Conrad, N. K., Wilson, S. M., Steinmetz, E. J., Patturajan, M., Brow, D. A., Swanson, M. S. & Corden, J. L., Feb 2000, In: Genetics. 154, 2, p. 557-571 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Heterogeneous-Nuclear Ribonucleoproteins 100%
  • RNA Polymerase II 79%
  • Two-Hybrid System Techniques 57%
  • Yeasts 55%
  • RNA-Binding Proteins 52%
  113 Scopus citations

• Balance between MAT2A intron detention and splicing is determined cotranscriptionally

  Pendleton, K. E., Park, S. K., Hunter, O. V., Bresson, S. M. & Conrad, N. K., Jun 2018, In: RNA. 24, 6, p. 778-786 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Introns 100%
  • S-Adenosylmethionine 27%
  • Messenger RNA 23%
  • RNA Precursors 23%
  • Methionine Adenosyltransferase 16%
  23 Scopus citations

• Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs

  Bresson, S. M., Hunter, O. V., Hunter, A. C. & Conrad, N. K., 2015, In: PLoS genetics. 11, 10, e1005610.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polynucleotide Adenylyltransferase 100%
  • Nuclear RNA 84%
  • Polyadenylation 79%
  • Untranslated RNA 70%
  • RNA 64%
  80 Scopus citations

• Chapter 15 Co-Immunoprecipitation Techniques for Assessing RNA-Protein Interactions In Vivo

  Conrad, N. K., 2008, In: Methods in Enzymology. 449, C, p. 317-342 26 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoprecipitation 100%
  • RNA 71%
  • Nuclear RNA 55%
  • Protein 42%
  • Proteins 37%
  29 Scopus citations

• Chapter 6 Posttranscriptional Gene Regulation in Kaposi's Sarcoma-Associated Herpesvirus

  Conrad, N. K., 2009, In: Advances in Applied Microbiology. 68, p. 241-261 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Herpesvirus 8 100%
  • Genes 31%
  • RNA Stability 19%
  • Multi-centric Castleman's Disease 13%
  • Primary Effusion Lymphoma 13%
  17 Scopus citations

• Chemical Reporters for Monitoring RNA Synthesis and Poly(A) Tail Dynamics

  Grammel, M., Hang, H. & Conrad, N. K., May 2012, In: ChemBioChem. 13, 8, p. 1112-1115 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  55 Scopus citations

• Chromatin Immunoprecipitation and Microarray Analysis Suggest Functional Cooperation between Kaposi's Sarcoma-Associated Herpesvirus ORF57 and K-bZIP

  Hunter, O. V., Sei, E., Blake Richardson, R. & Conrad, N. K., Apr 2013, In: Journal of virology. 87, 7, p. 4005-4016 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human gammaherpesvirus 8 100%
  • Human Herpesvirus 8 73%
  • Chromatin Immunoprecipitation 63%
  • microarray technology 62%
  • Microarray Analysis 58%
  14 Scopus citations

• Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity

  Sei, E. & Conrad, N. K., Oct 25 2011, In: Virology. 419, 2, p. 107-116 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Herpesvirus 8 100%
  • RNA 53%
  • Regulator Genes 16%
  • Nucleotides 12%
  • Binding Sites 11%
  28 Scopus citations

• Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy

  Stubbs, S. H. & Conrad, N. K., Sep 1 2015, In: Nucleic acids research. 43, 1, p. 504-519 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Polymerase II 100%
  • RNA 59%
  • Nuclear RNA 58%
  • Gene Expression 51%
  • RNA-Seq 50%
  22 Scopus citations

• Genetic analysis of second primary lung cancers in patients surviving small cell lung cancer

  Kelley, M. J., Nakagawa, K., Conrad, N. K., LeRiche, J., Murray, N., Lee, J. S., Ro, J. Y., Shaw, E. G., Tucker, M. A. & Johnson, B. E., Jul 1996, In: Clinical Cancer Research. 2, 7, p. 1103-1105 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Second Primary Neoplasms 100%
  • Small Cell Lung Carcinoma 97%
  • Lung Neoplasms 69%
  • Smoking 42%
  • Mutation 32%
  8 Scopus citations

• HITS-CLIP Analysis Uncovers a Link between the Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein and Host Pre-mRNA Metabolism

  Sei, E., Wang, T., Hunter, O. V., Xie, Y. & Conrad, N. K., 2015, In: PLoS pathogens. 11, 2, e1004652.

  Research output: Contribution to journal › Article › peer-review

  • Human gammaherpesvirus 8 100%
  • Human Herpesvirus 8 73%
  • high-throughput nucleotide sequencing 67%
  • RNA Precursors 64%
  • Immunoprecipitation 55%
  16 Scopus citations

• Identification of a Rapid Mammalian Deadenylation-Dependent Decay Pathway and Its Inhibition by a Viral RNA Element

  Conrad, N. K., Mili, S., Marshall, E. L., Shu, M. D. & Steitz, J. A., Dec 28 2006, In: Molecular cell. 24, 6, p. 943-953 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Viral RNA 100%
  • Nuclear RNA 82%
  • Globins 76%
  • RNA Precursors 69%
  • Messenger RNA 52%
  89 Scopus citations

• Influenza virus NS1 protein-RNA interactome reveals intron targeting

  Zhang, L., Wang, J., Muñoz-Moreno, R., Kim, M., Sakthivel, R., Mo, W., Shao, D., Anantharaman, A., García-Sastre, A., Conrad, N. K. & Fontoura, B. M., Dec 1 2018, In: Journal of virology. 92, 24, e0163418.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • influenza virus INS1 protein 100%
  • Orthomyxoviridae 67%
  • RNA Precursors 56%
  • Introns 54%
  • introns 49%
  19 Scopus citations

• Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding rna from cellular RNA decay pathways

  Sahin, B. B., Patel, D. & Conrad, N. K., Mar 2010, In: PLoS pathogens. 6, 3, e1000799.

  Research output: Contribution to journal › Article › peer-review

  • Human gammaherpesvirus 8 100%
  • Nuclear RNA 77%
  • Human Herpesvirus 8 73%
  • Untranslated RNA 64%
  • RNA Stability 63%
  63 Scopus citations

• Kaposi’s sarcoma-associated herpesvirus fine-tunes the temporal expression of late genes by manipulating a host RNA quality control pathway

  Ruiz, J. C., Devlin, A. M., Kim, J. & Conrad, N. K., Jul 1 2020, In: Journal of virology. 94, 14, e00287-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human gammaherpesvirus 8 100%
  • Human Herpesvirus 8 73%
  • Tuberculin 67%
  • Quality Control 55%
  • quality control 52%
  4 Scopus citations

• Kaposi’s sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment

  Ruiz, J. C., Hunter, O. V. & Conrad, N. K., Feb 2019, In: PLoS pathogens. 15, 2, e1007596.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human gammaherpesvirus 8 100%
  • Nuclear RNA 77%
  • Human Herpesvirus 8 73%
  • viral proteins 65%
  • RNA Stability 63%
  12 Scopus citations

• Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage

  Nakagawa, K., Conrad, N. K., Williams, J. P., Johnson, B. E. & Kelley, M. J., Nov 2 1995, In: Oncogene. 11, 9, p. 1842-1851 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Non-Small Cell Lung Carcinoma 100%
  • Point Mutation 93%
  • Tumor Cell Line 48%
  • Single-Stranded Conformational Polymorphism 43%
  • Neoplasms 36%
  78 Scopus citations

• Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylate tail

  Conrad, N. K., Shu, M. D., Uyhazi, K. E. & Steitz, J. A., Jun 19 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 25, p. 10412-10417 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Stability 100%
  • Viral RNA 99%
  • Base Pairing 93%
  • Nuclear RNA 61%
  • Human Herpesvirus 8 58%
  49 Scopus citations

• New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA

  Conrad, N. K., Jan 2 2016, In: Virus Research. 212, p. 53-63 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear RNA 100%
  • Human Herpesvirus 8 95%
  • Untranslated RNA 83%
  • Messenger RNA 42%
  • RNA Stability 11%
  41 Scopus citations

• Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

  Chorghade, S., Seimetz, J., Emmons, R., Yang, J., Bresson, S. M., de Lisio, M., Parise, G., Conrad, N. K. & Kalsotra, A., Jun 27 2017, In: eLife. 6, e24139.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(A)-Binding Protein I 100%
  • Protein Synthesis 79%
  • Heart 49%
  • Developmental 45%
  • Length 44%
  54 Scopus citations

• RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts

  Steinmetz, E. J., Conrad, N. K., Brow, D. A. & Corden, J. L., Sep 20 2001, In: Nature. 413, 6853, p. 327-331 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly A 100%
  • RNA Polymerase II 87%
  • RNA-Binding Proteins 86%
  • Small Nuclear RNA 54%
  • Messenger RNA 32%
  298 Scopus citations

• SAM homeostasis is regulated by CFI_m- mediated splicing of MAT2A

  Scarborough, A. M., Flaherty, J. N., Hunter, O. V., Liu, K., Kumar, A., Xing, C., Tu, B. P. & Conrad, N. K., May 2021, In: eLife. 10, e64930.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • S-Adenosylmethionine 100%
  • Intramuscular 92%
  • Introns 73%
  • Homeostasis 55%
  • Cleavage 52%
  16 Scopus citations

• Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

  Doxtader, K. A., Wang, P., Scarborough, A. M., Seo, D., Conrad, N. K. & Nam, Y., Sep 20 2018, In: Molecular cell. 71, 6, p. 1001-1011.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • S-Adenosylmethionine 100%
  • Homeostasis 55%
  • N(6)-methyladenosine 40%
  • RNA 35%
  • Methyltransferases 28%
  137 Scopus citations

• The challenge of viral snRNPs

  Conrad, N. K., Fok, V., Cazalla, D., Borah, S. & Steitz, J. A., 2006, In: Cold Spring Harbor symposia on quantitative biology. 71, p. 377-384 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Epstein-Barr virus encoded RNA 1 100%
  • Nuclear RNA 84%
  • Messenger RNA 71%
  • Untranslated RNA 70%
  • Mammalian Cell 64%
  8 Scopus citations

• The Human Nuclear Poly(A)-Binding Protein Promotes RNA Hyperadenylation and Decay

  Bresson, S. M. & Conrad, N. K., Oct 2013, In: PLoS genetics. 9, 10, e1003893.

  Research output: Contribution to journal › Article › peer-review

  • Polynucleotide Adenylyltransferase 100%
  • Poly(A)-Binding Proteins 98%
  • RNA-binding proteins 79%
  • RNA Stability 68%
  • RNA 64%
  94 Scopus citations

• The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4

  Kubo, A., Nakagawa, K., Varma, R. K., Conrad, N. K., Cheng, J. Q., Lee, W. C., Testa, J. R., Johnson, B. E., Kaye, F. J. & Kelley, M. J., Dec 1999, In: Clinical Cancer Research. 5, 12, p. 4279-4286 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 4 100%
  • Tumor Cell Line 71%
  • Phosphotransferases 54%
  • thioacridone 34%
  • Benzothiadiazines 26%
  72 Scopus citations

• The U6 snRNA m⁶A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention

  Pendleton, K. E., Chen, B., Liu, K., Hunter, O. V., Xie, Y., Tu, B. P. & Conrad, N. K., May 18 2017, In: Cell. 169, 5, p. 824-835.e14

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • U6 small nuclear RNA methyltransferase 100%
  • Methionine Adenosyltransferase 62%
  • S-Adenosylmethionine 50%
  • Methionine 39%
  • Introns 37%
  698 Scopus citations

• TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract

  Yang, H. K., Linnoila, R. I., Conrad, N. K., Krasna, M. J., Aisner, S. C., Johnson, B. E. & Kelley, M. J., Aug 22 1995, In: International Journal of Cancer. 64, 4, p. 229-233 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Neoplasms 57%
  • Codon 19%
  • Second Primary Neoplasms 11%
  • Missense Mutation 10%
  29 Scopus citations

• Viral factors reveal a role for REF/Aly in nuclear RNA stability

  Stubbs, S. H., Hunter, O. V., Hoover, A. & Conrad, N. K., Apr 2012, In: Molecular and cellular biology. 32, 7, p. 1260-1270 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nuclear RNA 100%
  • RNA Stability 81%
  • Messenger RNA 42%
  • Human Herpesvirus 8 23%
  • Quality Control 17%
  34 Scopus citations

• Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation

  Patturajan, M., Conrad, N. K., Bregman, D. B. & Corden, J. L., Sep 24 1999, In: Journal of Biological Chemistry. 274, 39, p. 27823-27828 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Polymerase II 100%
  • Serine 83%
  • Yeasts 69%
  • Phosphotransferases 66%
  • Phosphorylation 59%
  55 Scopus citations