Research output per year
Research output per year
- 1 - 50 out of 69 results
Search results
-
2023
Comprehensive phenotypic analysis of diverse FOXN1 variants
Moses, A., Bhalla, P., Thompson, A., Lai, L., Coskun, F. S., Seroogy, C. M., de la Morena, M. T., Wysocki, C. A. & van Oers, N. S. C., Nov 2023, In: Journal of Allergy and Clinical Immunology. 152, 5, p. 1273-1291.e15Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome
Bhalla, P., Du, Q., Kumar, A., Xing, C., Moses, A., Dozmorov, I., Wysocki, C. A., Cleaver, O. B., Pirolli, T. J., Markert, M. L., de la Morena, M. T., Baldini, A. & van Oers, N. S., Jul 3 2023, In: The Journal of clinical investigation. 133, 13Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome
Bhalla, P., Du, Q., Kumar, A., Xing, C., Moses, A., Dozmorov, I., Wysocki, C. A., Cleaver, O. B., Pirolli, T. J., Markert, M. L., de la Morena, M. T., Baldini, A. & van Oers, N. S. C., Nov 15 2022, In: Journal of Clinical Investigation. 132, 22, e160101.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2021
Impact of Bead-Beating Intensity on the Genus- and Species-Level Characterization of the Gut Microbiome Using Amplicon and Complete 16S rRNA Gene Sequencing
Zhang, B., Brock, M., Arana, C., Dende, C., van Oers, N. S., Hooper, L. V. & Raj, P., Oct 1 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 678522.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency
van Oers, N. S. C., Hanners, N. W., Sue, P., Aquino, V., Li, Q. Z., Schoggins, J. W. & Wysocki, C. A., Mar 2021, In: Clinical Immunology. 224, 108662.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses
Pichilingue-Reto, P., Raj, P., Li, Q. Z., Dozmorov, I., Karp, D. R., Wakeland, E. K., Nelson, M., Gruchalla, R. S., de la Morena, M. T. & van Oers, N. S. C., Jul 2021, In: Journal of Clinical Immunology. 41, 5, p. 1031-1047 17 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2020
Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus
Raj, P., Song, R., Zhu, H., Riediger, L., Jun, D. J., Liang, C., Arana, C., Zhang, B., Gao, Y., Wakeland, B. E., Dozmorov, I., Zhou, J., Kelly, J. A., Lauwerys, B. R., Guthridge, J. M., Olsen, N. J., Nath, S. K., Pasare, C., van Oers, N., Gilkeson, G., & 8 others, Dec 2020, In: Genome biology. 21, 1, 281.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
sncRNA-1 Is a Small Noncoding RNA Produced by Mycobacterium tuberculosis in Infected Cells That Positively Regulates Genes Coupled to Oleic Acid Biosynthesis
Coskun, F. S., Srivastava, S., Raj, P., Dozmorov, I., Belkaya, S., Mehra, S., Golden, N. A., Bucsan, A. N., Chapagain, M. L., Wakeland, E. K., Kaushal, D., Gumbo, T. & van Oers, N. S. C., Jul 28 2020, In: Frontiers in Microbiology. 11, 1631.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2019
FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans
Du, Q., Huynh, L. K., Coskun, F., Molina, E., King, M. A., Raj, P., Khan, S., Dozmorov, I., Seroogy, C. M., Wysocki, C. A., Padron, G. T., Yates, T. R., Louise Markert, M., Teresa de la Morena, M. & van Oers, N. S. C., Nov 1 2019, In: Journal of Clinical Investigation. 129, 11, p. 4724-4738 15 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary
Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T. C., de la Morena, M. T., Cleaver, O. B., Mendell, J. T. & van Oers, N. S. C., May 20 2019, In: Developmental cell. 49, 4, p. 618-631.e5Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
2017
Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations
Maryoung, L., Yue, Y., Young, A., Newton, C. A., Barba, C., Van Oers, N. S. C., Wang, R. C. & Garcia, C. K., Mar 1 2017, In: Journal of Clinical Investigation. 127, 3, p. 982-986 5 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
2016
MicroRNA-205 maintains T cell development following stress by regulating forkhead box N1 and selected chemokines
Hoover, A. R., Dozmorov, I., MacLeod, J., Du, Q., De La Teresa Morena, M., Forbess, J., Guleserian, K., Cleaver, O. B. & Van Oers, N. S. C., Oct 28 2016, In: Journal of Biological Chemistry. 291, 44, p. 23237-23247 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8
Khan, S., Kuruvilla, M., Hagin, D., Wakeland, B., Liang, C., Vishwanathan, K., Gatti, R. A., Torgersen, T. R., Abraham, R. S., Wakeland, E. K., van Oers, N. S. C. & de la Morena, M. T., Jul 1 2016, In: Journal of Allergy and Clinical Immunology. 138, 1, p. 289-292.e6Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells
Gonzales-van Horn, S. R., Estrada, L. D., van Oers, N. S. C. & Farrar, J. D., Jun 1 2016, In: European Journal of Immunology. 46, 6, p. 1504-1510 7 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2014
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
Iwashima, M., Irving, B. A., Van Oers, N. S. C., Chan, A. C. & Weiss, A., Nov 1 2014, In: Journal of Immunology. 193, 9, p. 4279-4282 4 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
The haemophilus ducreyi lspa1 protein inhibits phagocytosis by using a new mechanism involving Activation of C-terminal src kinase
Dodd, D. A., Worth, R. G., Rosen, M. K., Grinstein, S., van Oers, N. S. C. & Hansen, E. J., May 20 2014, In: mBio. 5, 3, e01178-14.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Transgenic expression of microRNA-181d augments the stress-sensitivity of CD4+CD8+ thymocytes
Belkaya, S. & Van Oers, N. S. C., Jan 9 2014, In: PloS one. 9, 1Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2013
Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion/DiGeorge syndrome
De la Morena, M. T., Eitson, J. L., Dozmorov, I. M., Belkaya, S., Hoover, A. R., Anguiano, E., Pascual, M. V. & van Oers, N. S. C., Apr 2013, In: Clinical Immunology. 147, 1, p. 11-22 12 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1
Belkaya, S., Murray, S. E., Eitson, J. L., De La Morena, M. T., Forman, J. A. & Van Oers, N. S. C., Oct 18 2013, In: Journal of Biological Chemistry. 288, 42, p. 30752-30762 11 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
2012
Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages
Eitson, J. L., Medeiros, J. J., Hoover, A. R., Srivastava, S., Roybal, K. T., Aínsa, J. A., Hansen, E. J., Gumbo, T. & Van Oersa, N. S. C., Oct 2012, In: Applied and environmental microbiology. 78, 19, p. 6829-6837 9 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The antibiotic resistance arrow of time: Efflux pump induction is a general first step in the evolution of mycobacterial drug resistance
Schmalstieg, A. M., Srivastava, S., Belkaya, S., Deshpande, D., Meek, C., Leff, R., Van Oers, N. S. C. & Gumbo, T., Sep 2012, In: Antimicrobial agents and chemotherapy. 56, 9, p. 4806-4815 10 p.Research output: Contribution to journal › Article › peer-review
Open Access144 Scopus citations -
2011
Basal and antigen-induced exposure of the proline-rich sequence in CD3ε
De La Cruz, J., Kruger, T., Parks, C. A., Silge, R. L., Van Oers, N. S. C., Luescher, I. F., Schrum, A. G. & Gil, D., Feb 15 2011, In: Journal of Immunology. 186, 4, p. 2282-2290 9 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Dynamic modulation of thymic microRNAs in response to stress
Belkaya, S., Silge, R. L., Hoover, A. R., Medeiros, J. J., Eitson, J. L., Becker, A. M., de la Morena, M. T., Bassel-Duby, R. S. & van Oers, N. S. C., Nov 16 2011, In: PloS one. 6, 11, e27580.Research output: Contribution to journal › Article › peer-review
41 Scopus citations -
The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse
DeFord-Watts, L. M., Dougall, D. S., Belkaya, S., Johnson, B. A., Eitson, J. L., Roybal, K. T., Barylko, B., Albanesi, J. P., Wülfing, C. & Van Oers, N. S. C., Jun 15 2011, In: Journal of Immunology. 186, 12, p. 6839-6847 9 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
2010
A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting In impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as mrsa subdural empyema
Devora, G. A., Sun, L., Chen, Z., Van Oers, N. S. C., Hanson, E. P., Orange, J. S. & De La Morena, M. T., Nov 2010, In: Journal of Clinical Immunology. 30, 6, p. 881-885 5 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Invariant NKT cell development requires a full complement of functional CD3 ζ immunoreceptor tyrosine-based activation motifs
Becker, A. M., Blevins, J. S., Tomson, F. L., Eitson, J. L., Medeiros, J. J., Yarovinsky, F., Norgard, M. V. & Van Oers, N. S. C., Jun 15 2010, In: Journal of Immunology. 184, 12, p. 6822-6832 11 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2009
Spatiotemporal patterning during T cell activation is highly diverse
Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., Van Oers, N. S. C. & Wülfing, C., Apr 7 2009, In: Science signaling. 2, 65, p. ra15Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
The cytoplasmic tail of the T cell receptor CD3 ε subunit contains a phospholipid-binding motif that regulates T cell functions
DeFord-Watts, L. M., Tassin, T. C., Becker, A. M., Medeiros, J. J., Albanesi, J. P., Love, P. E., Wülfing, C. & Van Oers, N. S. C., Jul 15 2009, In: Journal of Immunology. 183, 2, p. 1055-1064 10 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
2008
Haemophilus ducreyi LspA proteins are tyrosine phosphorylated by macrophage-encoded protein tyrosine kinases
Deng, K., Mock, J. R., Greenberg, S., Van Oers, N. S. C. & Hansen, E. J., Oct 2008, In: Infection and immunity. 76, 10, p. 4692-4702 11 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity
Holst, J., Wang, H., Eder, K. D., Workman, C. J., Boyd, K. L., Baquet, Z., Singh, H., Forbes, K., Chruscinski, A., Smeyne, R., van Oers, N. S. C., Utz, P. J. & Vignali, D. A. A., Jun 2008, In: Nature immunology. 9, 6, p. 658-666 9 p.Research output: Contribution to journal › Article › peer-review
127 Scopus citations -
The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions
Young, J. A., Becker, A. M., Medeiros, J. J., Shapiro, V. S., Wang, A., Farrar, J. D., Quill, T. A., van Huijsduijnen, R. H. & van Oers, N. S. C., Aug 2008, In: Molecular Immunology. 45, 14, p. 3756-3766 11 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2007
The constitutive tyrosine phosphorylation of CD3ζ results from TCR-MHC interactions that are independent of thymic selection
Becker, A. M., DeFord-Watts, L. M., Wuelfing, C. & Van Oers, N. S. C., Apr 1 2007, In: Journal of Immunology. 178, 7, p. 4120-4128 9 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
The membrane-proximal portion of CD3 ε associates with the serine/threonine kinase GRK2
DeFord-Watts, L. M., Young, J. A., Pitcher, L. A. & Van Oers, N. S. C., Jun 1 2007, In: Journal of Biological Chemistry. 282, 22, p. 16126-16134 9 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
2005
Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling
Mock, J. R., Vakevainen, M., Deng, K., Latimer, J. L., Young, J. A., Van Oers, N. S. C., Greenberg, S. & Hansen, E. J., Dec 2005, In: Infection and immunity. 73, 12, p. 7808-7816 9 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR ζ promotes the emergence of T cells with autoreactive potential
Pitcher, L. A., Mathis, M. A., Subramanian, S., Young, J. A., Wakeland, E. K., Love, P. E. & Van Oers, N. S. C., May 15 2005, In: Journal of Immunology. 174, 10, p. 6071-6079 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells
Purtic, B., Pitcher, L. A., Van Oers, N. S. C. & Wülfing, C., Feb 22 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 8, p. 2904-2909 6 p.Research output: Contribution to journal › Article › peer-review
81 Scopus citations -
The CD3 γε/δε signalling module provides normal T cell functions in the absence of the TCR ζ immunoreceptor tyrosine-based activation motifs
Pitcher, L. A., Mathis, M. A., Young, J. A., DeFord, L. M., Purtic, B., Wulfing, C. & van Oers, N. S. C., Dec 2005, In: European Journal of Immunology. 35, 12, p. 3643-3654 12 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
2004
PTPH1 Is a Predominant Protein-tyrosine Phosphatase Capable of Interacting with and Dephosphorylating the T Cell Receptor ζ Subunit
Sozio, M. S., Mathis, M. A., Young, J. A., Wälchli, S., Pitcher, L. A., Wrage, P. C., Bartók, B., Campbell, A., Watts, J. D., Aebersold, R., Van Huijsduijnen, R. H. & Van Oers, N. S. C., Feb 27 2004, In: Journal of Biological Chemistry. 279, 9, p. 7760-7769 10 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
2003
T cell antagonism is functionally uncoupled from the 21- and 23-kDa tyrosine-phosphorylated TCR ζ subunits
Pitcher, L. A., Ohashi, P. S. & Van Oers, N. S. C., Jul 15 2003, In: Journal of Immunology. 171, 2, p. 845-852 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2002
I-κB kinases α and β have distinct roles in regulating murine T cell function
Ren, H., Schmalstieg, A., Van Oers, N. S. C. & Gaynor, R. B., Apr 15 2002, In: Journal of Immunology. 168, 8, p. 3721-3731 11 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Positive selection by the pre-TCR yields mature CD8+ T cells
Ito, Y., Arai, S., Van Oers, N. S. C., Aifantis, I., Von Boehmer, H. & Miyazaki, T., Nov 1 2002, In: Journal of Immunology. 169, 9, p. 4913-4919 7 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2000
Tetracycline-controllable selection of CD4+ T cells: Half-life and survival signals in the absence of major histocompatibility complex class II molecules
Witherden, D., Van Oers, N., Waltzinger, C., Weiss, A., Benoist, C. & Mathis, D., Jan 17 2000, In: Journal of Experimental Medicine. 191, 2, p. 355-364 10 p.Research output: Contribution to journal › Article › peer-review
138 Scopus citations -
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
Van Oers, N. S. C., Tohlen, B., Malissen, B., Moomaw, C. R., Afendis, S. & Slaughter, C. A., Oct 2000, In: Nature immunology. 1, 4, p. 322-328 7 p.Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
1999
Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression
Chu, D. H., Van Oers, N. S. C., Malissen, M., Harris, J., Elder, M. & Weiss, A., Sep 1 1999, In: Journal of Immunology. 163, 5, p. 2610-2620 11 p.Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
T cell receptor-mediated signs and signals governing T cell development
Van Oers, N. S. C., Aug 1999, In: Seminars in Immunology. 11, 4, p. 227-237 11 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
1998
Differential requirements for ZAP-70 in TCR signaling and T cell development
Kadlecek, T. A., Van Oers, N. S. C., Lefrancois, L., Olson, S., Finlay, D., Chu, D. H., Connolly, K., Killeen, N. & Weiss, A., Nov 1 1998, In: Journal of Immunology. 161, 9, p. 4688-4694 7 p.Research output: Contribution to journal › Article › peer-review
109 Scopus citations -
Regulation of TCR signal transduction in murine thymocytes by multiple TCR ζ-chain signaling motifs
Van Oers, N. S. C., Love, P. E., Shores, E. W. & Weiss, A., Jan 1 1998, In: Journal of Immunology. 160, 1, p. 163-170 8 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
1997
Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development
Page, S. T., Van Oers, N. S. C., Perlmutter, R. M., Weiss, A. & Pullen, A. M., 1997, In: European Journal of Immunology. 27, 2, p. 554-562 9 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling
Qian, D., Lev, S., Van Oers, N. S. C., Dikic, I., Schlessinger, J. & Weiss, A., Apr 7 1997, In: Journal of Experimental Medicine. 185, 7, p. 1253-1259 7 p.Research output: Contribution to journal › Article › peer-review
152 Scopus citations -
1996
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
Van Oers, N. S. C., Killeen, N. & Weiss, A., Mar 1 1996, In: Journal of Experimental Medicine. 183, 3, p. 1053-1062 10 p.Research output: Contribution to journal › Article › peer-review
287 Scopus citations