Research output per year
Research output per year
- 1 - 50 out of 80 results
Search results
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2023
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells
Ceglia, S., Berthelette, A., Howley, K., Li, Y., Mortzfeld, B., Bhattarai, S. K., Yiew, N. K. H., Xu, Y., Brink, R., Cyster, J. G., Hooper, L. V., Randolph, G. J., Bucci, V. & Reboldi, A., Mar 2023, In: Nature immunology. 24, 3, p. 531-544 14 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Macrophages regulate gastrointestinal motility through complement component 1q
Pendse, M., De Selle, H., Vo, N., Quinn, G., Dende, C., Li, Y., Salinas, C. N., Srinivasan, T., Propheter, D. C., Crofts, A. A., Koo, E., Hassell, B., Ruhn, K. A., Raj, P., Obata, Y. & Hooper, L. V., Apr 2023, In: eLife. 12, e78558.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2022
Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells
Carroll, D. J., Burns, M. W. N., Mottram, L., Propheter, D. C., Boucher, A., Lessen, G. M., Kumar, A., Malaker, S. A., Xing, C., Hooper, L. V., Yrlid, U. & Kohler, J. J., Feb 1 2022, In: Journal of Biological Chemistry. 298, 2, 101463.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2021
Impact of Bead-Beating Intensity on the Genus- and Species-Level Characterization of the Gut Microbiome Using Amplicon and Complete 16S rRNA Gene Sequencing
Zhang, B., Brock, M., Arana, C., Dende, C., van Oers, N. S., Hooper, L. V. & Raj, P., Oct 1 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 678522.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Serum amyloid a delivers retinol to intestinal myeloid cells to promote adaptive immunity
Bang, Y. J., Hu, Z., Li, Y., Gattu, S., Ruhn, K. A., Raj, P., Herz, J. & Hooper, L. V., Sep 17 2021, In: Science. 373, 6561, eabf9232.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection
Hu, Z., Zhang, C., Sifuentes-Dominguez, L., Zarek, C. M., Propheter, D. C., Kuang, Z., Wang, Y., Pendse, M., Ruhn, K. A., Hassell, B., Behrendt, C. L., Zhang, B., Raj, P., Harris-Tryon, T. A., Reese, T. A. & Hooper, L. V., Nov 5 2021, In: Science. 374, 6568, eabe6723.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
2019
Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity
Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris, T. A., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Molecular basis for retinol binding by serum amyloid A during infection
Hu, Z., Bang, Y. J., Ruhn, K. A. & Hooper, L. V., Sep 17 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19077-19082 6 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin
Harris, T. A., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In: Cell Host and Microbe. 25, 6, p. 777-788.e8Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3
Kuang, Z., Wang, Y., Li, Y., Ye, C., Ruhn, K. A., Behrendt, C. L., Olson, E. N. & Hooper, L. V., Sep 27 2019, In: Science. 365, 6460, p. 1428-1434 7 p.Research output: Contribution to journal › Article › peer-review
Open Access188 Scopus citations -
2018
Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth
Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Jan 10 2018, In: Cell Host and Microbe. 23, 1, p. 54-64.e6Research output: Contribution to journal › Article › peer-review
Open Access124 Scopus citations -
Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation
Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Feb 14 2018, In: Cell Host and Microbe. 23, 2, p. 177-190.e4Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
Murine colitis reveals a disease-associated bacteriophage community
Duerkop, B. A., Kleiner, M., Paez-Espino, D., Zhu, W., Bushnell, B., Hassell, B., Winter, S. E., Kyrpides, N. C. & Hooper, L. V., Sep 1 2018, In: Nature microbiology. 3, 9, p. 1023-1031 9 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
Precision editing of the gut microbiota ameliorates colitis
Zhu, W., Winter, M. G., Byndloss, M. X., Spiga, L., Duerkop, B. A., Hughes, E. R., Büttner, L., De Lima Romão, E., Behrendt, C. L., Lopez, C. A., Sifuentes-Dominguez, L., Huff-Hardy, K., Wilson, R. P., Gillis, C. C., Tükel, Ç., Koh, A. Y., Burstein, E., Hooper, L. V., Bäumler, A. J. & Winter, S. E., Jan 11 2018, In: Nature. 553, 7687, p. 208-211 4 p.Research output: Contribution to journal › Article › peer-review
Open Access361 Scopus citations -
Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease
Zhao, D., Kim, Y. H., Jeong, S., Greenson, J. K., Chaudhry, M. S., Hoepting, M., Anderson, E. R., van den Brink, M. R., Peled, J. U., Gomes, A. L., Slingerland, A. E., Donovan, M. J., Harris, A. C., Levine, J. E., Ozbek, U., Hooper, L. V., Stappenbeck, T. S., Ver Heul, A., Liu, T. C., Reddy, P., & 1 others, Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4970-4979 10 p.Research output: Contribution to journal › Article › peer-review
Open Access88 Scopus citations -
The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion
Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V. & Farrar, J. D., Nov 2018, In: Brain, Behavior, and Immunity. 74, p. 176-185 10 p.Research output: Contribution to journal › Article › peer-review
Open Access123 Scopus citations -
2017
An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate
Spiga, L., Winter, M. G., Furtado de Carvalho, T., Zhu, W., Hughes, E. R., Gillis, C. C., Behrendt, C. L., Kim, J., Chessa, D., Andrews-Polymenis, H. L., Beiting, D. P., Santos, R. L., Hooper, L. V. & Winter, S. E., Sep 13 2017, In: Cell Host and Microbe. 22, 3, p. 291-301.e6Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice
Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis
Hughes, E. R., Winter, M. G., Duerkop, B. A., Spiga, L., Furtado de Carvalho, T., Zhu, W., Gillis, C. C., Büttner, L., Smoot, M. P., Behrendt, C. L., Cherry, S., Santos, R. L., Hooper, L. V. & Winter, S. E., Feb 8 2017, In: Cell Host and Microbe. 21, 2, p. 208-219 12 p.Research output: Contribution to journal › Article › peer-review
Open Access213 Scopus citations -
NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways
Udden, S. M. N., Peng, L., Gan, J. L., Shelton, J. M., Malter, J. S., Hooper, L. V. & Zaki, M. H., Jun 27 2017, In: Cell Reports. 19, 13, p. 2756-2770 15 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
Bel, S., Pendse, M., Wang, Y., Ii, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J. & Hooper, L. V., Sep 8 2017, In: Science. 357, 6355, p. 1047-1052 6 p.Research output: Contribution to journal › Article › peer-review
Open Access248 Scopus citations -
Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium
Propheter, D. C., Chara, A. L., Harris, T. A., Ruhn, K. A. & Hooper, L. V., Oct 17 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11027-11033 7 p.Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations -
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M. & Hooper, L. V., Sep 1 2017, In: Science. 357, 6354, p. 912-916 5 p.Research output: Contribution to journal › Article › peer-review
Open Access289 Scopus citations -
2016
Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species
Chatzidaki-Livanis, M., Geva-Zatorsky, N., Comstock, L. E. & Hooper, L. V., Mar 29 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3627-3632 6 p.Research output: Contribution to journal › Article › peer-review
Open Access142 Scopus citations -
Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation
Wang, L., Fouts, D. E., Stärkel, P., Hartmann, P., Chen, P., Llorente, C., DePew, J., Moncera, K., Ho, S. B., Brenner, D. A., Hooper, L. V. & Schnabl, B., 2016, In: Cell Host and Microbe. 19, 2, p. 227-239 13 p.Research output: Contribution to journal › Article › peer-review
Open Access267 Scopus citations -
Molecular basis for lytic bacteriophage resistance in enterococci
Duerkop, B. A., Huo, W., Bhardwaj, P., Palmer, K. L. & Hooper, L. V., Jul 1 2016, In: mBio. 7, 4, e01304-16.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Pulmonary Th17 antifungal immunity is regulated by the gut microbiome
McAleer, J. P., Nguyen, N. L. H., Chen, K., Kumar, P., Ricks, D. M., Binnie, M., Armentrout, R. A., Pociask, D. A., Hein, A., Yu, A., Vikram, A., Bibby, K., Umesaki, Y., Rivera, A., Sheppard, D., Ouyang, W., Hooper, L. V. & Kolls, J. K., Jul 1 2016, In: Journal of Immunology. 197, 1, p. 97-107 11 p.Research output: Contribution to journal › Article › peer-review
Open Access88 Scopus citations -
2015
Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis
Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V. & Koh, A. Y., Aug 1 2015, In: PLoS pathogens. 11, 8, e1005129.Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
Cutting edge: Developmental regulation of IFN-γ production by mouse neutrophil precursor cells
Sturge, C. R., Burger, E., Raetz, M., Hooper, L. V. & Yarovinsky, F., Jul 1 2015, In: Journal of Immunology. 195, 1, p. 36-40 5 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Epithelial Cell Contributions to Intestinal Immunity
Hooper, L. V., 2015, In: Advances in Immunology. 126, p. 129-172 44 p.Research output: Contribution to journal › Article › peer-review
93 Scopus citations -
Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes
Kleiner, M., Hooper, L. V. & Duerkop, B. A., Jan 22 2015, In: BMC Genomics. 16, 1, 7.Research output: Contribution to journal › Article › peer-review
132 Scopus citations -
Immunology: A bacterial nudge to T-cell function
Bel, S. & Hooper, L. V., Oct 15 2015, In: Nature. 526, 7573, p. 328-330 3 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense
Hu, S., Peng, L., Kwak, Y. T., Tekippe, E. M., Pasare, C., Malter, J. S., Hooper, L. V. & Zaki, M. H., Dec 1 2015, In: Cell Reports. 13, 9, p. 1922-1936 15 p.Research output: Contribution to journal › Article › peer-review
Open Access92 Scopus citations -
2014
Antibacterial membrane attack by a pore-forming intestinal C-type lectin
Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo-Rey, J., Grabe, M., Jiang, Q. X. & Hooper, L. V., 2014, In: Nature. 505, 7481, p. 103-107 5 p.Research output: Contribution to journal › Article › peer-review
236 Scopus citations -
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S. & Hooper, L. V., Jul 29 2014, In: eLife. 3, July2014, p. 1-18 18 p., e03206.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
Yu, X., Wang, Y., Deng Ph.D., M., Li, Y., Ruhn, K. A., Zhang, C. & Hooper, L. V., Oct 13 2014, In: eLife. 3, e04406.Research output: Contribution to journal › Article › peer-review
Open Access188 Scopus citations -
2013
Intestinal epithelial autophagy is essential for host defense against invasive bacteria
Benjamin, J. L., Sumpter, R., Levine, B. & Hooper, L. V., Jun 12 2013, In: Cell Host and Microbe. 13, 6, p. 723-734 12 p.Research output: Contribution to journal › Article › peer-review
244 Scopus citations -
Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
Li, Y., Zhang, Q., Carreira-Rosario, A., Maines, J. Z., McKearin, D. M. & Buszczak, M., Mar 20 2013, In: PloS one. 8, 3, e58301.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
Raetz, M., Hwang, S. H., Wilhelm, C. L., Kirkland, D., Benson, A., Sturge, C. R., Mirpuri, J., Vaishnava, S., Hou, B., Defranco, A. L., Gilpin, C. J., Hooper, L. V. & Yarovinsky, F., Feb 2013, In: Nature immunology. 14, 2, p. 136-142 7 p.Research output: Contribution to journal › Article › peer-review
Open Access157 Scopus citations -
Proteobacteria-specific IgA regulates maturation of the intestinal microbiota
Mirpuri, J., Raetz, M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V. & Yarovinsky, F., Sep 25 2013, In: Gut Microbes. 5, 1, p. 28-39 12 p.Research output: Contribution to journal › Article › peer-review
Open Access198 Scopus citations -
TH17 cell differentiation is regulated by the circadian clock
Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S. & Hooper, L. V., 2013, In: Science. 342, 6159, p. 727-730 4 p.Research output: Contribution to journal › Article › peer-review
Open Access320 Scopus citations -
Understanding the microbiota in the midst of Renaissance architecture and olive groves
Guarner, F., Hooper, L. V. & Núñez, G., Feb 2013, In: Nature immunology. 14, 2, p. 101-105 5 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2012
A composite bacteriophage alters colonization by an intestinal commensal bacterium
Duerkop, B. A., Clements, C. V., Rollins, D., Rodrigues, J. L. M. & Hooper, L. V., Oct 23 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17621-17626 6 p.Research output: Contribution to journal › Article › peer-review
Open Access182 Scopus citations -
Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity
Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 2012, In: Genes and Development. 26, 12, p. 1306-1311 6 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling
Li, Y., Maines, J. Z., Tastan, Ö. Y., McKearin, D. M. & Buszczak, M., May 1 2012, In: Development. 139, 9, p. 1547-1556 10 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
2011
Intestinal microbiota promote enteric virus replication and systemic pathogenesis
Kuss, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J., Frierson, J. M., Hooper, L. V., Dermody, T. S. & Pfeiffer, J. K., Oct 14 2011, In: Science. 334, 6053, p. 249-252 4 p.Research output: Contribution to journal › Article › peer-review
Open Access470 Scopus citations -
Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
Li, X. D., Chiu, Y. H., Ismail, A. S., Behrendt, C. L., Wight-Carter, M., Hooper, L. V. & Chen, Z. J., Oct 18 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17390-17395 6 p.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
Recombinant lectin microarrays for glycomic analysis.
Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 15 2011, In: Methods in molecular biology (Clifton, N.J.). 723, p. 67-77 11 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine
Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K. & Hooper, L. V., Oct 14 2011, In: Science. 334, 6053, p. 255-258 4 p.Research output: Contribution to journal › Article › peer-review
Open Access1076 Scopus citations -
γδ intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface
Ismail, A. S., Severson, K. M., Vaishnava, S., Behrendt, C. L., Yu, X., Benjamin, J. L., Ruhn, K. A., Hou, B., DeFranco, A. L., Yarovinsky, F. & Hooper, L. V., May 24 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 21, p. 8743-8748 6 p.Research output: Contribution to journal › Article › peer-review
Open Access247 Scopus citations