Center for Alzheimer's and Neurodegenerative Diseases

Research output

Research output per year 2016 2021 2022 2023 2024 2024

• 49 Article
• 9 Review article
• 2 Chapter
• 2 Comment/debate

Research output per year

Research output per year

Search results

• 2024

  Blood Markers in Relation to a History of Traumatic Brain Injury Across Stages of Cognitive Impairment in a Diverse Cohort

  Lobue, C., Stopschinski, B. E., Saez Calveras, N., Douglas, P. M., Huebinger, R., Cullum, C. M., Hart, J. & Gonzales, M. M., Jan 2 2024, In: Journal of Alzheimer's Disease. 97, 1, p. 345-358 14 p.

  Research output: Contribution to journal › Article › peer-review

  • cognitive impairment 100%
  • Traumatic Brain Injury 80%
  • brain 68%
  • Cognitive Dysfunction 66%
  • dementia 63%

• Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population

  Hendren, N. S., De Lemos, J. A., Berry, J. D., Kozlitina, J., Saelices, L., Ji, A. X., Shao, Z., Liu, C. F., Garg, S., Farr, M. A., Drazner, M. H., Tang, W. H. W. & Grodin, J. L., 2024, (Accepted/In press) In: Amyloid.

  Research output: Contribution to journal › Article › peer-review

  • Retinol-Binding Proteins 100%
  • Prealbumin 92%
  • Middle Aged 75%
  • Population 29%
  • Linear Models 7%

• DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity

  Ryder, B. D., Ustyantseva, E., Boyer, D. R., Mendoza-Oliva, A., Kuska, M. I., Wydorski, P. M., Macierzyńska, P., Morgan, N., Sawaya, M. R., Diamond, M. I., Kampinga, H. H. & Joachimiak, L. A., 2024, (Accepted/In press) In: Structure.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Domains 100%
  • Molecular Chaperones 40%
  • Protein Folding 38%
  • Proteome 34%
  • Seeds 33%
  1 Scopus citations

• Docking for Molecules That Bind in a Symmetric Stack with SymDOCK

  Smith, M. S., Knight, I. S., Kormos, R. C., Pepe, J. G., Kunach, P., Diamond, M. I., Shahmoradian, S. H., Irwin, J. J., DeGrado, W. F. & Shoichet, B. K., Jan 22 2024, In: Journal of Chemical Information and Modeling. 64, 2, p. 425-434 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ligands 100%
  • Molecules 73%
  • Ligand 33%
  • energy 30%
  • Molecule 26%

• Hairpin trimer transition state of amyloid fibril

  Sari, L., Bali, S., Joachimiak, L. A. & Lin, M. M., Dec 2024, In: Nature communications. 15, 1, 2756.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloid Fibril 100%
  • trimers 99%
  • Trimer 82%
  • Amyloid 79%
  • Transition State 69%

• Local structural preferences in shaping tau amyloid polymorphism

  Louros, N., Wilkinson, M., Tsaka, G., Ramakers, M., Morelli, C., Garcia, T., Gallardo, R., D’Haeyer, S., Goossens, V., Audenaert, D., Thal, D. R., Mackenzie, I. R., Rademakers, R., Ranson, N. A., Radford, S. E., Rousseau, F. & Schymkowitz, J., Dec 2024, In: Nature communications. 15, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • polymorphism 100%
  • Amyloid Fibril 91%
  • Amyloid 73%
  • Disorder 66%
  • Strain 53%

• Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength

  Rios, M. U., Bagnucka, M. A., Ryder, B. D., Ferreira Gomes, B., Familiari, N. E., Yaguchi, K., Amato, M., Stachera, W. E., Joachimiak, Ł. A. & Woodruff, J. B., Apr 1 2024, In: The Journal of cell biology. 223, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Centrosome 100%
  • Microtubules 77%
  • Caenorhabditis elegans Proteins 63%
  • Phosphorylation 55%
  • Spindle Apparatus 49%

• N-glycosylation as a eukaryotic protective mechanism against protein aggregation

  Duran-Romaña, R., Houben, B., De Vleeschouwer, M., Louros, N., Wilson, M. P., Matthijs, G., Schymkowitz, J. & Rousseau, F., Feb 2024, In: Science Advances. 10, 5, eadk8173.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycosylation 100%
  • Post Translational Protein Processing 50%
  • Proteins 35%
  • Proteome 33%
  • Eukaryota 16%

• O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology

  Balana, A. T., Mahul-Mellier, A. L., Nguyen, B. A., Horvath, M., Javed, A., Hard, E. R., Jasiqi, Y., Singh, P., Afrin, S., Pedretti, R., Singh, V., Lee, V. M. Y., Luk, K. C., Saelices, L., Lashuel, H. A. & Pratt, M. R., 2024, (Accepted/In press) In: Nature chemical biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Amyloid 62%
  • Pathology 41%
  • Parkinson Disease 22%
  • Amyloidogenic Proteins 17%

• Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

  Nguyen, B. A., Singh, V., Afrin, S., Yakubovska, A., Wang, L., Ahmed, Y., Pedretti, R., Fernandez-Ramirez, M. D. C., Singh, P., Pękała, M., Cabrera Hernandez, L. O., Kumar, S., Lemoff, A., Gonzalez-Prieto, R., Sawaya, M. R., Eisenberg, D. S., Benson, M. D. & Saelices, L., Dec 2024, In: Nature communications. 15, 1, 581.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cryoelectron Microscopy 100%
  • Cryo-Electron Microscopy 96%
  • polymorphism 95%
  • Amyloid Fibril 87%
  • Amyloidosis 82%
  1 Scopus citations
• 2023

  Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds

  Hitt, B. D., Gupta, A., Singh, R., Yang, T., Beaver, J. D., Shang, P., White, C. L., Joachimiak, L. A. & Diamond, M. I., Nov 2023, In: Journal of Biological Chemistry. 299, 11, 105252.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pick Disease of the Brain 100%
  • Epitope 89%
  • Seeds 89%
  • Progressive Supranuclear Palsy 88%
  • Epitopes 75%
  1 Scopus citations

• Disease-associated patterns of acetylation stabilize tau fibril formation

  Li, L., Nguyen, B. A., Mullapudi, V., Li, Y., Saelices, L. & Joachimiak, L. A., Sep 7 2023, In: Structure. 31, 9, p. 1025-1037.e4

  Research output: Contribution to journal › Article › peer-review

  • Acetylation 100%
  • Amyloid 60%
  • Lysine 46%
  • Tauopathies 21%
  • beta-Strand Protein Conformation 18%
  2 Scopus citations

• DnaJC7 specifically regulates tau seeding

  Perez, V. A., Sanders, D. W., Mendoza-Oliva, A., Stopschinski, B. E., Mullapudi, V., White, C. L., Joachimiak, L. A. & Diamond, M. I., Jun 2023, In: eLife. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Domains 100%
  • Mutation 41%
  • Protective 40%
  • Tauopathies 33%
  • tau Proteins 31%
  3 Scopus citations

• Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

  Wydorski, P. M., Osipiuk, J., Lanham, B. T., Tesar, C., Endres, M., Engle, E., Jedrzejczak, R., Mullapudi, V., Michalska, K., Fidelis, K., Fushman, D., Joachimiak, A. & Joachimiak, L. A., Dec 2023, In: Nature communications. 14, 1, 2366.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • papain 100%
  • protease 84%
  • SARS Virus 84%
  • Papain 74%
  • Ubiquitin 57%
  8 Scopus citations

• FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

  Chen, D., Bali, S., Singh, R., Wosztyl, A., Mullapudi, V., Vaquer-Alicea, J., Jayan, P., Melhem, S., Seelaar, H., van Swieten, J. C., Diamond, M. I. & Joachimiak, L. A., Dec 2023, In: Nature communications. 14, 1, 1625.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia 100%
  • mutations 93%
  • Amyloid 75%
  • Mutation 67%
  • Data Aggregation 43%
  4 Scopus citations

• Hydrostatic Pressure Sensing by WNK kinases

  Humphreys, J. M., Teixeira, L. R., Akella, R., He, H., Kannangara, A. R., Sekulski, K., Pleinis, J., Liwocha, J., Jiou, J., Servage, K. A., Orth, K., Joachimiak, L., Rizo, J., Cobb, M. H., Brautigam, C. A., Rodan, A. R. & Goldsmith, E. J., Oct 1 2023, In: Molecular biology of the cell. 34, 11, ar109.

  Research output: Contribution to journal › Article › peer-review

  • Hydrostatic Pressure 100%
  • Phosphotransferases 59%
  • Gases 25%
  • Malpighian Tubules 25%
  • Pressure 20%
  2 Scopus citations

• Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

  Tayeb-Fligelman, E., Bowler, J. T., Tai, C. E., Sawaya, M. R., Jiang, Y. X., Garcia, G., Griner, S. L., Cheng, X., Salwinski, L., Lutter, L., Seidler, P. M., Lu, J., Rosenberg, G. M., Hou, K., Abskharon, R., Pan, H., Zee, C. T., Boyer, D. R., Li, Y., Anderson, D. H., & 8 othersMurray, K. A., Falcon, G., Cascio, D., Saelices, L., Damoiseaux, R., Arumugaswami, V., Guo, F. & Eisenberg, D. S., Dec 2023, In: Nature communications. 14, 1, 2379.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Nucleocapsid Proteins 93%
  • Amyloid Fibril 80%
  • Amyloid 64%
  • proteins 53%
  4 Scopus citations

• LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

  Libé-Philippot, B., Lejeune, A., Wierda, K., Louros, N., Erkol, E., Vlaeminck, I., Beckers, S., Gaspariunaite, V., Bilheu, A., Konstantoulea, K., Nyitrai, H., De Vleeschouwer, M., Vennekens, K. M., Vidal, N., Bird, T. W., Soto, D. C., Jaspers, T., Dewilde, M., Dennis, M. Y., Rousseau, F., & 5 othersComoletti, D., Schymkowitz, J., Theys, T., de Wit, J. & Vanderhaeghen, P., Dec 21 2023, In: Cell. 186, 26, p. 5766-5783.e25

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Voltage-Gated Sodium Channels 100%
  • Cortical Excitability 99%
  • Axons 64%
  • Neurons 45%
  • Pyramidal Cells 44%

• Network of hotspot interactions cluster tau amyloid folds

  Mullapudi, V., Vaquer-Alicea, J., Bommareddy, V., Vega, A. R., Ryder, B. D., White, C. L., Diamond, M. I. & Joachimiak, L. A., Dec 2023, In: Nature communications. 14, 1, 895.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloid 100%
  • proteins 83%
  • Amyloidogenic Proteins 70%
  • Molecular Cluster 68%
  • Microtubule-Associated Proteins 62%
  7 Scopus citations

• Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation

  Chlebowicz, J., Russ, W., Chen, D., Vega, A., Vernino, S., White, C. L., Rizo, J., Joachimiak, L. A. & Diamond, M. I., Oct 27 2023, In: Science Advances. 9, 43, eadh3457.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Synucleinopathies 92%
  • Mutagenesis 65%
  • Protein Conformation 29%
  • Prions 27%

• The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

  Saha, I., Yuste-Checa, P., Da Silva Padilha, M., Guo, Q., Körner, R., Holthusen, H., Trinkaus, V. A., Dudanova, I., Fernández-Busnadiego, R., Baumeister, W., Sanders, D. W., Gautam, S., Diamond, M. I., Hartl, F. U. & Hipp, M. S., Dec 2023, In: Nature communications. 14, 1, 560.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Seeds 62%
  • seeds 56%
  • proteins 48%
  • machinery 30%
  8 Scopus citations
• 2022

  Clinical Reasoning: A 59-Year-Old Man with Thymoma and Constitutional Symptoms, Seizures, and Multifocal CNS Lesions

  Stopschinski, B. E., Fredrich, S., Vernino, S., Phillips, L. & Blackburn, K. M., Dec 13 2022, In: Neurology. 99, 24, p. 1115-1121 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thymoma 100%
  • Seizures 64%
  • Cholinergic Receptors 60%
  • Arm 48%
  • Antibodies 45%

• Evidence-Based Evaluation and Management of Cognitive Impairment in Dementia With Lewy Bodies

  Khera, A., Stopschinski, B. E. & Chiang, H. S., Oct 1 2022, In: Psychiatric Annals. 52, 10, p. 404-409 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Lewy Body Disease 100%
  • Cognitive Dysfunction 64%
  • Behavioral Symptoms 23%
  • Dementia 16%
  • Pharmacology 13%

• Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

  Lu, S., Hu, J., Arogundade, O. A., Goginashvili, A., Vazquez-Sanchez, S., Diedrich, J. K., Gu, J., Blum, J., Oung, S., Ye, Q., Yu, H., Ravits, J., Liu, C., Yates, J. R. & Cleveland, D. W., Sep 2022, In: Nature cell biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heat-Shock Response 100%
  • Gels 74%
  • Amyotrophic Lateral Sclerosis 64%
  • RNA 62%
  • Psychological Inhibition 49%
  36 Scopus citations

• Large-Size Subunit Catalases Are Chimeric Proteins: A H₂ O₂ Selecting Domain with Catalase Activity Fused to a Hsp31-Derived Domain Conferring Protein Stability and Chaperone Activity

  Hansberg, W., Nava-Ramírez, T., Rangel-Silva, P., Díaz-Vilchis, A. & Mendoza-Oliva, A., May 2022, In: Antioxidants. 11, 5, 979.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • recombinant fusion proteins 100%
  • Protein Stability 90%
  • Staphylococcal Protein A 88%
  • protein domains 83%
  • Catalase 73%
  4 Scopus citations

• RNA induces unique tau strains and stabilizes Alzheimer's disease seeds

  Zwierzchowski-Zarate, A. N., Mendoza-Oliva, A., Kashmer, O. M., Collazo-Lopez, J. E., White, C. L. & Diamond, M. I., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Seeds 100%
  • Alzheimer Disease 76%
  • Strain 68%
  • RNA 68%
  • Tauopathies 38%
  16 Scopus citations

• Seed-competent tau monomer initiates pathology in a tauopathy mouse model

  Mirbaha, H., Chen, D., Mullapudi, V., Terpack, S. J., White, C. L., Joachimiak, L. A. & Diamond, M. I., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Seeds 75%
  • Pathology 46%
  • Monomer 43%
  • Phosphorylation 20%
  15 Scopus citations

• The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics

  Wickramaratne, A. C., Li, L., Hopkins, J. B., Joachimiak, L. A. & Green, C. B., Jun 7 2022, In: Biochemistry. 61, 11, p. 1091-1102 12 p.

  Research output: Contribution to journal › Article › peer-review

  • NADP phosphatase 100%
  • nocturnin 88%
  • Leucine 46%
  • Enzymes 24%
  • Leucine Zippers 23%
  4 Scopus citations

• VCP suppresses proteopathic seeding in neurons

  Zhu, J., Pittman, S., Dhavale, D., French, R., Patterson, J. N., Kaleelurrrahuman, M. S., Sun, Y., Vaquer-Alicea, J., Maggiore, G., Clemen, C. S., Buscher, W. J., Bieschke, J., Kotzbauer, P., Ayala, Y., Diamond, M. I., Davis, A. A. & Weihl, C., Dec 2022, In: Molecular neurodegeneration. 17, 1, 30.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Neurons 37%
  • Biosensing Techniques 26%
  • Seeds 16%
  • Mutation 12%
  11 Scopus citations
• 2021

  AAV9-mediated FIG4 delivery prolongs life span in Charcot-Marie-Tooth disease type 4J mouse model

  Presa, M., Bailey, R. M., Davis, C., Murphy, T., Cook, J., Walls, R., Wilpan, H., Bogdanik, L., Lenk, G. M., Burgess, R. W., Gray, S. J. & Lutz, C., Jun 2021, In: Journal of Clinical Investigation. 131, 11, e137159.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type 4j Charcot-Marie-Tooth Disease 100%
  • Dependovirus 56%
  • Serogroup 41%
  • Longevity 40%
  • Loss of Function Mutation 10%
  14 Scopus citations

• A Compartmentalized Neuronal Cell-Culture Platform Compatible With Cryo-Fixation by High-Pressure Freezing for Ultrastructural Imaging

  Tran, H. T., Lucas, M. S., Ishikawa, T., Shahmoradian, S. H. & Padeste, C., Sep 8 2021, In: Frontiers in Neuroscience. 15, 726763.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Freezing 100%
  • Cell Culture Techniques 75%
  • Electron Microscopy 68%
  • Pressure 64%
  • Neurons 60%
  1 Scopus citations

• Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns

  Stopschinski, B. E., Del Tredici, K., Estill-Terpack, S. J., Ghebremdehin, E., Yu, F. F., Braak, H. & Diamond, M. I., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alzheimer Disease 100%
  • Pathology 81%
  • Brain 63%
  • Tauopathies 49%
  • Basal Nucleus of Meynert 26%
  14 Scopus citations

• Biophysical properties of a tau seed

  Hou, Z., Chen, D., Ryder, B. D. & Joachimiak, L. A., Jun 30 2021, In: Scientific reports. 11, 1, p. 13602 1 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Seeds 100%
  • Tauopathies 88%
  • Heparin 14%
  • Mass Spectrometry 14%
  • In Vitro Techniques 14%
  17 Scopus citations

• Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores

  Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B. A., Lu, J., Murray, K. A., Kandeel, F. & Eisenberg, D. S., Sep 2021, In: Nature Structural and Molecular Biology. 28, 9, p. 724-730 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Islet Amyloid Polypeptide 100%
  • Amyloid 67%
  • Amyloidosis 13%
  • Seeds 12%
  • Islets of Langerhans 11%
  41 Scopus citations

• DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

  Hou, Z., Wydorski, P. M., Perez, V. A., Mendoza-Oliva, A., Ryder, B. D., Mirbaha, H., Kashmer, O. & Joachimiak, L. A., Dec 1 2021, In: Nature communications. 12, 1, 5338.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Domains 100%
  • Amyloid 93%
  • Tetratricopeptide Repeat 74%
  • tau Proteins 62%
  • Molecular Chaperones 60%
  10 Scopus citations

• Extensive rod and cone photoreceptor-cell degeneration in rat models of giant axonal neuropathy: implications for gene therapy of human disease

  Armao, D., Bouldin, T. W., Bailey, R. M. & Gray, S. J., 2021, In: Ophthalmic Genetics. 42, 5, p. 600-603 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Giant Axonal Neuropathy 100%
  • Retinal Cone Photoreceptor Cells 74%
  • Retinal Rod Photoreceptor Cells 73%
  • Photoreceptor Cells 69%
  • Vertebrate Photoreceptor Cells 68%
  2 Scopus citations

• HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

  Yu, H., Lu, S., Gasior, K., Singh, D., Vazquez-Sanchez, S., Tapia, O., Toprani, D., Beccari, M. S., Yates, J. R., Da Cruz, S., Newby, J. M., Lafarga, M., Gladfelter, A. S., Villa, E. & Cleveland, D. W., Feb 5 2021, In: Science. 371, 6529, eabb4309.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteasome Endopeptidase Complex 100%
  • Acetylation 67%
  • RNA 66%
  • Adenosine Triphosphate 49%
  • RNA Recognition Motif 48%
  136 Scopus citations

• Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

  Ryder, B. D., Matlahov, I., Bali, S., Vaquer-Alicea, J., van der Wel, P. C. A. & Joachimiak, L. A., Dec 1 2021, In: Nature communications. 12, 1, 946.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteostasis 100%
  • Substrate Specificity 85%
  • interactions 30%
  • Proteins 28%
  • Surface 24%
  13 Scopus citations

• Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF

  Hitt, B. D., Vaquer-Alicea, J., Manon, V. A., Beaver, J. D., Kashmer, O. M., Garcia, J. N. & Diamond, M. I., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 99.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biosensing Techniques 100%
  • Cerebrospinal Fluid 71%
  • Alzheimer Disease 63%
  • Seeds 62%
  • Fluorescence Resonance Energy Transfer 54%
  24 Scopus citations
• 2020

  A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

  Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S. & Diamond, M. I., Mar 6 2020, In: Journal of Biological Chemistry. 295, 10, p. 2974-2983 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heparinoid 100%
  • Heparinoids 92%
  • Heparin 59%
  • Prions 53%
  • Tauopathies 39%
  23 Scopus citations
• 2019

  Advancing the pathologic phenotype of giant axonal neuropathy: Early involvement of the ocular lens

  Armao, D., Bouldin, T. W., Bailey, R. M., Hooper, J. E., Bharucha, D. X. & Gray, S. J., Feb 1 2019, In: Orphanet Journal of Rare Diseases. 14, 1, 27.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Giant Axonal Neuropathy 100%
  • Crystalline Lens 70%
  • Intermediate Filaments 60%
  • Inclusion Bodies 45%
  • Lenses 37%
  10 Scopus citations

• Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

  Gasset-Rosa, F., Lu, S., Yu, H., Chen, C., Melamed, Z., Guo, L., Shorter, J., Da Cruz, S. & Cleveland, D. W., Apr 17 2019, In: Neuron. 102, 2, p. 339-357.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Nucleus Active Transport 100%
  • Neurodegenerative Diseases 73%
  • Cell Death 64%
  266 Scopus citations

• Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment

  Jiang, L. L., Zhu, B., Zhao, Y., Li, X., Liu, T., Pina-Crespo, J., Zhou, L., Xu, W., Rodriguez, M. J., Yu, H., Cleveland, D. W., Ravits, J., Cruz, S. D., Long, T., Zhang, D., Huang, T. Y. & Xu, H., Aug 1 2019, In: Journal of Clinical Investigation. 129, 8, p. 3103-3120 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Glutamic Acid 81%
  • Astrocytes 71%
  • Homeostasis 68%
  • Motor Neurons 45%
  26 Scopus citations

• Propagation of protein aggregation in neurodegenerative diseases

  Vaquer-Alicea, J. & Diamond, M. I., Jun 20 2019, In: Annual review of biochemistry. 88, p. 785-810 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloidogenic Proteins 100%
  • Neurodegenerative Diseases 97%
  • Neuropathology 83%
  • Amyloid 70%
  • Synucleins 56%
  186 Scopus citations

• Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

  Yang, T., Dang, Y., Ostaszewski, B., Mengel, D., Steffen, V., Rabe, C., Bittner, T., Walsh, D. M. & Selkoe, D. J., Aug 2019, In: Annals of Neurology. 86, 2, p. 215-224 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • crenezumab 100%
  • Amyloid 44%
  • Cerebrospinal Fluid 40%
  • Placebos 26%
  • Alzheimer Disease 18%
  65 Scopus citations
• 2018

  Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus -synuclein and -amyloid aggregates

  Stopschinski, B. E., Holmes, B. B., Miller, G. M., Manon, V. A., Vaquer-Alicea, J., Prueitt, W. L., Hsieh-Wilson, L. C. & Diamond, M. I., Jul 6 2018, In: Journal of Biological Chemistry. 293, 27, p. 10826-10840 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Heparan Sulfate Proteoglycan 99%
  • Heparan Sulfate Proteoglycans 84%
  • Glycosaminoglycan 76%
  • Glycosaminoglycans 70%
  118 Scopus citations
• 2017

  Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor

  Hou, Z., Su, L., Pei, J., Grishin, N. V. & Zhang, H., Aug 1 2017, In: Structure. 25, 8, p. 1187-1194.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chlorpropham 100%
  • Transcriptional Activation 46%
  • Protein Databases 10%
  • Hydrogen Bonding 10%
  • Invertebrates 9%
  7 Scopus citations

• Widespread tau seeding activity at early Braak stages

  Furman, J. L., Vaquer-Alicea, J., White, C. L., Cairns, N. J., Nelson, P. T. & Diamond, M. I., Jan 1 2017, In: Acta Neuropathologica. 133, 1, p. 91-100 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Fluorescence Resonance Energy Transfer 65%
  • Alzheimer Disease 57%
  • Parietal Lobe 48%
  • Frontal Lobe 46%
  97 Scopus citations
• 2016

  Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

  Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M. & Diamond, M. I., Nov 23 2016, In: Neuron. 92, 4, p. 796-812 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Prions 90%
  • Pathology 46%
  • Brain 24%
  • Neurodegenerative Diseases 21%
  286 Scopus citations