Research output per year
Research output per year
- 49 results
Search results
-
2020
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase
Koirala, S., Klein, J., Zheng, Y., Glenn, N. O., Eisemann, T., Fon Tacer, K., Miller, D. J., Kulak, O., Lu, M., Finkelstein, D. B., Neale, G., Tillman, H., Vogel, P., Strand, D. W., Lum, L., Brautigam, C. A., Pascal, J. M., Clements, W. K. & Potts, P. R., Jul 21 2020, In: Cell Reports. 32, 3, 107922.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2019
CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation
Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In: Nature communications. 10, 1, 4056.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9
Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 2019, In: EBioMedicine. 39, p. 145-158 14 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2018
A synthetic combinatorial approach to disabling deviant Hedgehog signaling
Fan, C. W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C. & Lum, L., Dec 1 2018, In: Scientific reports. 8, 1, 1133.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
EGF receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors
Chen, K., Fustino, N. J., Shukla, A. A., Stroup, E. K., Budhipramono, A., Ateek, C., Stuart, S. H., Yamaguchi, K., Kapur, P., Frazier, A. L., Lum, L., Looijenga, L. H. J., Laetsch, T. W., Rakheja, D. & Amatruda, J. F., May 2018, In: Molecular Cancer Therapeutics. 17, 5, p. 1079-1089 11 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Regulation of tankyrase activity by a catalytic domain dimer interface
Fan, C., Yarravarapu, N., Chen, H., Kulak, O., Dasari, P., Herbert, J., Yamaguchi, K., Lum, L. & Zhang, X., Sep 10 2018, In: Biochemical and Biophysical Research Communications. 503, 3, p. 1780-1785 6 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2017
Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist
Moon, J., Zhou, H., Zhang, L. S., Tan, W., Liu, Y., Zhang, S., Morlock, L. K., Bao, X., Palecek, S. P., Feng, J. Q., Williams, N. S., Amatruda, J. F., Olson, E. N., Bassel-Duby, R. & Lum, L., Feb 14 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1649-1654 6 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
Wu, X., Zhang, L. S., Toombs, J., Kuo, Y. C., Piazza, J. T., Tuladhar, R., Barrett, Q., Fan, C. W., Zhang, X., Walensky, L. D., Kool, M., Cheng, S. Y., Brekken, R., Opferman, J. T., Green, D. R., Moldoveanu, T. & Lum, L., Sep 29 2017, In: Nature cell biology. 19, 10, p. 1226-1236 11 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
2016
Development of a triazole class of highly potent Porcn inhibitors
You, L., Zhang, C., Yarravarapu, N., Morlock, L., Wang, X., Zhang, L., Williams, N. S., Lum, L. & Chen, C., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5891-5895 5 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2015
Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine
Lum, L. & Chen, C., Dec 1 2015, In: Current Medicinal Chemistry. 22, 35, p. 4091-4103 13 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells
Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In: Molecular and cellular biology. 35, 14, p. 2425-2435 11 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Fatty acyl donor selectivity in membrane bound o-acyltransferases and communal cell fate decision-making
Tuladhar, R. & Lum, L., Apr 1 2015, In: Biochemical Society Transactions. 43, p. 235-239 5 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts
Kulak, O., Yamaguchi, K. & Lum, L., 2015, In: Methods in Molecular Biology. 1263, p. 3-16 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Role of the exocyst complex component Sec6/8 in genomic stability
Torres, M. J., Pandita, R. K., Kulak, O., Kumar, R., Formstecher, E., Horikoshi, N., Mujoo, K., Hunt, C. R., Zhao, Y., Lum, L., Zaman, A., Yeaman, C., White, M. A. & Pandita, T. K., 2015, In: Molecular and cellular biology. 35, 21, p. 3633-3645 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2014
Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens
Zhong, R., Kim, J., Kim, H. S., Kim, M., Lum, L., Levine, B., Xiao, G., White, M. A. & Xie, Y., Jul 29 2014, In: Nucleic acids research. 42, 13, p. 8214-8222 9 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer
Singel, S. M., Cornelius, C., Zaganjor, E., Batten, K., Sarode, V. R., Buckley, D. L., Peng, Y., John, G. B., Li, H. C., Sadeghi, N., Wright, W. E., Lum, L., Corson, T. W. & Shay, J. W., Mar 2014, In: Neoplasia (United States). 16, 3, p. 247-256.e2 e2.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation
Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In: Chemistry and Biology. 21, 12, p. 1680-1689 10 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
2013
A multiplexed luciferase-based screening platform for interrogating cancer-associated signal transduction in cultured cells.
Kulak, O. & Lum, L., 2013, In: Journal of visualized experiments : JoVE. 77, p. e50369Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer
Singel, S. M., Cornelius, C., Batten, K., Fasciani, G., Wright, W. E., Lum, L. & Shay, J. W., Apr 15 2013, In: Clinical Cancer Research. 19, 8, p. 2061-2070 10 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
Das, A., Tanigawa, S., Karner, C. M., Xin, M., Lum, L., Chen, C., Olson, E. N., Perantoni, A. O. & Carroll, T. J., Sep 2013, In: Nature cell biology. 15, 9, p. 1035-1044 10 p.Research output: Contribution to journal › Article › peer-review
Open Access183 Scopus citations -
The development of highly potent inhibitors for porcupine
Wang, X., Moon, J., Dodge, M. E., Pan, X., Zhang, L., Hanson, J. M., Tuladhar, R., Ma, Z., Shi, H., Williams, N. S., Amatruda, J. F., Carroll, T. J., Lum, L. & Chen, C., Mar 28 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2700-2704 5 p.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
2012
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine
Dodge, M. E., Moon, J., Tuladhar, R., Lu, J., Jacob, L. S., Zhang, L. S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C. M., Carroll, T. J., Chen, C., Amatruda, J. F. & Lum, L., Jun 29 2012, In: Journal of Biological Chemistry. 287, 27, p. 23246-23254 9 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains
Moro, E., Ozhan-Kizil, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R. M., Bournele, D., Domenichini, A., Valdivia, L. E., Lum, L., Chen, C., Amatruda, J. F., Tiso, N., Weidinger, G. & Argenton, F., Jun 15 2012, In: Developmental Biology. 366, 2, p. 327-340 14 p.Research output: Contribution to journal › Article › peer-review
181 Scopus citations -
Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression
Zhang, X., Farrell, A. S., Daniel, C. J., Arnold, H., Scanlan, C., Laraway, B. J., Janghorban, M., Lum, L., Chen, D., Troxell, M. & Sears, R., Feb 21 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2790-2795 6 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids
Gao, S., Wang, Q., Wang, G., Lomenick, B., Liu, J., Fan, C. W., Deng, L. W., Huang, J., Lum, L. & Chen, C., 2012, In: Synlett. 23, 16, p. 2298-2310 13 p., ST-2012-A0436-A.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2011
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development
Karner, C. M., Das, A., Ma, Z., Self, M., Chen, C., Lum, L., Oliver, G. & Carroll, T. J., Apr 2011, In: Development. 138, 7, p. 1247-1257 11 p.Research output: Contribution to journal › Article › peer-review
225 Scopus citations -
Drugging the cancer stem cell compartment: Lessons learned from the hedgehog andwnt signal transduction pathways
Dodge, M. E. & Lum, L., Feb 10 2011, In: Annual review of pharmacology and toxicology. 51, p. 289-310 22 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling
Jacob, L. S., Wu, X., Dodge, M. E., Fan, C. W., Kulak, O., Chen, B., Tang, W., Wang, B., Amatruda, J. F. & Lum, L., Jan 25 2011, In: Science signaling. 4, 157, ra4.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells
Ren, Y., Lee, M. Y., Schliffke, S., Paavola, J., Amos, P. J., Ge, X., Ye, M., Zhu, S., Senyei, G., Lum, L., Ehrlich, B. E. & Qyang, Y., Sep 2011, In: Journal of Molecular and Cellular Cardiology. 51, 3, p. 280-287 8 p.Research output: Contribution to journal › Article › peer-review
Open Access124 Scopus citations -
2010
Chemical and biological studies of nakiterpiosin and nakiterpiosinone
Gao, S., Wang, Q., Huang, L. J. S., Lum, L. & Chen, C., Jan 13 2010, In: Journal of the American Chemical Society. 132, 1, p. 371-383 13 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
Tankyrase is necessary for canonical Wnt signaling during kidney development
Karner, C. M., Merkel, C. E., Dodge, M., Ma, Z., Lu, J., Chen, C., Lum, L. & Carroll, T. J., Jul 2010, In: Developmental Dynamics. 239, 7, p. 2014-2023 10 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
2009
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., Wei, S., Hao, W., Kilgore, J., Williams, N. S., Roth, M. G., Amatruda, J. F., Chen, C. & Lum, L., Feb 6 2009, In: Nature chemical biology. 5, 2, p. 100-107 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1158 Scopus citations -
Structure-activity relationship studies of small-molecule inhibitors of Wnt response
Lu, J., Ma, Z., Hsieh, J. C., Fan, C. W., Chen, B., Longgood, J. C., Williams, N. S., Amatruda, J. F., Lum, L. & Chen, C., Jul 15 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3825-3827 3 p.Research output: Contribution to journal › Article › peer-review
118 Scopus citations -
2008
A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
Tang, W., Dodge, M., Gundapaneni, D., Michnoff, C., Roth, M. & Lum, L., Jul 15 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 28, p. 9697-9702 6 p.Research output: Contribution to journal › Article › peer-review
152 Scopus citations -
2006
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells
Dorner, S., Lum, L., Kim, M., Paro, R., Beachy, P. A. & Green, R., Aug 8 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 11880-11885 6 p.Research output: Contribution to journal › Article › peer-review
51 Scopus citations -
Minimizing the risk of reporting false positives in large-scale RNAi screens
Echeverri, C. J., Beachy, P. A., Baum, B., Boutros, M., Buchholz, F., Chanda, S. K., Downward, J., Ellenberg, J., Fraser, A. G., Hacohen, N., Hahn, W. C., Jackson, A. L., Kiger, A., Linsley, P. S., Lum, L., Ma, Y., Mathey-Prévôt, B., Root, D. E., Sabatini, D. M., Taipale, J., & 2 others, Oct 2006, In: Nature methods. 3, 10, p. 777-779 3 p.Research output: Contribution to journal › Article › peer-review
Open Access379 Scopus citations -
Prevalence of off-target effects in Drosophila RNA interference screens
Ma, Y., Creanga, A., Lum, L. & Beachy, P. A., Sep 21 2006, In: Nature. 443, 7109, p. 359-363 5 p.Research output: Contribution to journal › Article › peer-review
242 Scopus citations -
The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation
Yao, S., Lum, L. & Beachy, P., Apr 21 2006, In: Cell. 125, 2, p. 343-357 15 p.Research output: Contribution to journal › Article › peer-review
182 Scopus citations -
2004
Evidence for a Critical Role of the Tumor Necrosis Factor α Convertase (TACE) in Ectodomain Shedding of the p75 Neurotrophin Receptor (p75NTR)
Weskamp, G., Schlöndorff, J., Lum, L., Becherer, J. D., Kim, T. W., Saftig, P., Hartmann, D., Murphy, G. & Blobel, C. P., Feb 6 2004, In: Journal of Biological Chemistry. 279, 6, p. 4241-4249 9 p.Research output: Contribution to journal › Article › peer-review
132 Scopus citations -
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
Zhang, C., Williams, E. H., Guo, Y., Lum, L. & Beachy, P. A., Dec 28 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 52, p. 17900-17907 8 p.Research output: Contribution to journal › Article › peer-review
150 Scopus citations -
2003
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
Lum, L., Zhang, C., Oh, S., Mann, R. K., Von Kessler, D. P., Taipale, J., Weis-Garcia, F., Gong, R., Wang, B. & Beachy, P. A., Nov 2003, In: Molecular cell. 12, 5, p. 1261-1274 14 p.Research output: Contribution to journal › Article › peer-review
197 Scopus citations -
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
Lum, L., Yao, S., Mozer, B., Rovescalli, A., Von Kessler, D., Nirenberg, M. & Beachy, P. A., Mar 28 2003, In: Science. 299, 5615, p. 2039-2045 7 p.Research output: Contribution to journal › Article › peer-review
470 Scopus citations -
Potential role for ADAM15 in pathological neovascularization in mice
Horiuchi, K., Weskamp, G., Lum, L., Hammes, H. P., Cai, H., Brodie, T. A., Ludwig, T., Chiusaroli, R., Baron, R., Preissner, K. T., Manova, K. & Blobel, C. P., Aug 2003, In: Molecular and cellular biology. 23, 16, p. 5614-5624 11 p.Research output: Contribution to journal › Article › peer-review
Open Access157 Scopus citations -
2001
Biochemical and Pharmacological Criteria Define Two Shedding Activities for TRANCE/OPGL That Are Distinct from the Tumor Necrosis Factor α Convertase
Schlöndorff, J., Lum, L. & Blobel, C. P., May 4 2001, In: Journal of Biological Chemistry. 276, 18, p. 14665-14674 10 p.Research output: Contribution to journal › Article › peer-review
116 Scopus citations -
1999
Evidence for a role of a tumor necrosis factor-α (TNF-α)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
Lum, L., Wong, B. R., Josien, R., Becherer, J. D., Erdjument-Bromage, H., Schlöndorff, J., Tempst, P., Choi, Y. & Blobel, C. P., May 7 1999, In: Journal of Biological Chemistry. 274, 19, p. 13613-13618 6 p.Research output: Contribution to journal › Article › peer-review
371 Scopus citations -
1998
Cloning and initial characterization of mouse meltrin β and analysis of the expression of four metalloproteasedisintegrins in bone cells
Inoue, D., Reid, M., Lum, L., Krätzschmar, J., Weskamp, G., Myung, Y. M., Baron, R. & Blobel, C. P., Feb 13 1998, In: Journal of Biological Chemistry. 273, 7, p. 4180-4187 8 p.Research output: Contribution to journal › Article › peer-review
95 Scopus citations -
Intracellular maturation of the mouse metalloprotease disintegrin MDC15
Lum, L., Reid, M. S. & Blobel, C. P., Oct 2 1998, In: Journal of Biological Chemistry. 273, 40, p. 26236-26247 12 p.Research output: Contribution to journal › Article › peer-review
138 Scopus citations -
1997
Evidence for distinct serine protease activities with a potential role in processing the sperm protein fertilin
Lum, L. & Blobel, C. P., Nov 1 1997, In: Developmental Biology. 191, 1, p. 131-145 15 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
1996
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence
Krätzschmar, J., Lum, L. & Blobel, C. P., Mar 1 1996, In: Journal of Biological Chemistry. 271, 9, p. 4593-4596 4 p.Research output: Contribution to journal › Article › peer-review
155 Scopus citations