Research output per year
Research output per year
- 1 - 50 out of 62 results
Search results
-
2023
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects
Huff, J. L., Poignant, F., Rahmanian, S., Khan, N., Blakely, E. A., Britten, R. A., Chang, P., Fornace, A. J., Hada, M., Kronenberg, A., Norman, R. B., Patel, Z. S., Shay, J. W., Weil, M. M., Simonsen, L. C. & Slaba, T. C., Feb 2023, In: Life Sciences in Space Research. 36, p. 90-104 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
The Molecular Mechanisms and Therapeutic Prospects of Alternative Lengthening of Telomeres (ALT)
Sohn, E. J., Goralsky, J. A., Shay, J. W. & Min, J., Apr 2023, In: Cancers. 15, 7, 1945.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
2020
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma
Moreno, L., Barone, G., DuBois, S. G., Molenaar, J., Fischer, M., Schulte, J., Eggert, A., Schleiermacher, G., Speleman, F., Chesler, L., Geoerger, B., Hogarty, M. D., Irwin, M. S., Bird, N., Blanchard, G. B., Buckland, S., Caron, H., Davis, S., De Wilde, B., Deubzer, H. E., & 18 others, Sep 2020, In: European Journal of Cancer. 136, p. 52-68 17 p.Research output: Contribution to journal › Review article › peer-review
34 Scopus citations -
Immortalized normal human lung epithelial cell models for studying lung cancer biology
Sato, M., Shay, J. W. & Minna, J. D., Sep 2020, In: Respiratory Investigation. 58, 5, p. 344-354 11 p.Research output: Contribution to journal › Review article › peer-review
16 Scopus citations -
2018
Comparison of telomere length measurement methods
Lai, T. P., Wright, W. E. & Shay, J. W., Mar 5 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1741, 20160451.Research output: Contribution to journal › Review article › peer-review
Open Access170 Scopus citations -
Telomeres and aging
Shay, J. W., Jun 2018, In: Current Opinion in Cell Biology. 52, p. 1-7 7 p.Research output: Contribution to journal › Review article › peer-review
111 Scopus citations -
2017
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer
Zhang, L. & Shay, J. W., Aug 1 2017, In: Journal of the National Cancer Institute. 109, 8, djw332.Research output: Contribution to journal › Review article › peer-review
Open Access239 Scopus citations -
Mutations, Cancer and the Telomere Length Paradox
Aviv, A., Anderson, J. J. & Shay, J. W., Apr 2017, In: Trends in Cancer. 3, 4, p. 253-258 6 p.Research output: Contribution to journal › Review article › peer-review
85 Scopus citations -
Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention
Jafri, M. A., Al-Qahtani, M. H. & Shay, J. W., Jun 2017, In: Seminars in Cancer Biology. 44, p. 117-131 15 p.Research output: Contribution to journal › Review article › peer-review
89 Scopus citations -
Telomere-associated aging disorders
Opresko, P. L. & Shay, J. W., Jan 1 2017, In: Ageing Research Reviews. 33, p. 52-66 15 p.Research output: Contribution to journal › Review article › peer-review
108 Scopus citations -
2016
Role of telomeres and telomerase in aging and cancer
Shay, J. W., Jun 2016, In: Cancer discovery. 6, 6, p. 584-593 10 p.Research output: Contribution to journal › Review article › peer-review
429 Scopus citations -
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
Jafri, M. A., Ansari, S. A., Alqahtani, M. H. & Shay, J. W., Jun 20 2016, In: Genome Medicine. 8, 1, 69.Research output: Contribution to journal › Review article › peer-review
Open Access434 Scopus citations -
2015
Concepts and challenges in cancer risk prediction for the space radiation environment
Barcellos-Hoff, M. H., Blakely, E. A., Burma, S., Fornace, A. J., Gerson, S., Hlatky, L., Kirsch, D. G., Luderer, U., Shay, J., Wang, Y. & Weil, M. M., Jul 1 2015, In: Life Sciences in Space Research. 6, p. 92-103 12 p., 68.Research output: Contribution to journal › Review article › peer-review
Open Access78 Scopus citations -
MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer
Jafri, M. A., Zaidi, S. K., Ansari, S. A., Al-Qahtani, M. H. & Shay, J. W., Dec 2 2015, In: Expert Opinion on Therapeutic Targets. 19, 12, p. 1705-1723 19 p.Research output: Contribution to journal › Review article › peer-review
18 Scopus citations -
2014
Alternative splicing regulation of telomerase: A new paradigm?
Wong, M. S., Wright, W. E. & Shay, J. W., Oct 1 2014, In: Trends in Genetics. 30, 10, p. 430-438 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access70 Scopus citations -
Telomeropathies: An emerging spectrum disorder
Holohan, B., Wright, W. E. & Shay, J. W., 2014, In: Journal of Cell Biology. 205, 3, p. 289-299 11 p.Research output: Contribution to journal › Review article › peer-review
132 Scopus citations -
2013
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations
Hunt, C. R., Ramnarain, D., Horikoshi, N., Iyengar, P., Pandita, R. K., Shay, J. W. & Pandita, T. K., Apr 2013, In: Radiation research. 179, 4, p. 383-392 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access108 Scopus citations -
2012
Is telomerase a viable target in cancer?
Buseman, C. M., Wright, W. E. & Shay, J. W., Feb 1 2012, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 730, 1-2, p. 90-97 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access119 Scopus citations -
2011
Role of telomeres and telomerase in cancer
Shay, J. W. & Wright, W. E., Dec 2011, In: Seminars in Cancer Biology. 21, 6, p. 349-353 5 p.Research output: Contribution to journal › Review article › peer-review
401 Scopus citations -
Targeting telomerase-expressing cancer cells
Ouellette, M. M., Wright, W. E. & Shay, J. W., Jul 2011, In: Journal of Cellular and Molecular Medicine. 15, 7, p. 1433-1442 10 p.Research output: Contribution to journal › Review article › peer-review
63 Scopus citations -
2010
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy
Sullivan, J. P., Minna, J. D. & Shay, J. W., Mar 2010, In: Cancer and Metastasis Reviews. 29, 1, p. 61-72 12 p.Research output: Contribution to journal › Review article › peer-review
146 Scopus citations -
Telomere biology in Metazoa
Gomes, N. M. V., Shay, J. W. & Wright, W. E., Sep 2010, In: FEBS Letters. 584, 17, p. 3741-3751 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access143 Scopus citations -
Telomeres and telomerase in normal and cancer stem cells
Shay, J. W. & Wright, W. E., Sep 2010, In: FEBS Letters. 584, 17, p. 3819-3825 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access184 Scopus citations -
2009
Is telomerase a novel target for metastatic colon cancer?
Roig, A. I., Wright, W. E. & Shay, J. W., Oct 2009, In: Current Colorectal Cancer Reports. 5, 4, p. 203-208 6 p.Research output: Contribution to journal › Review article › peer-review
11 Scopus citations -
Pancreatic cancer stem cells: Fact or fiction?
Bhagwandin, V. J. & Shay, J. W., Apr 2009, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 4, p. 248-259 12 p.Research output: Contribution to journal › Review article › peer-review
33 Scopus citations -
Prostate tumor-initiating cells: A new target for telomerase inhibition therapy?
Marian, C. O. & Shay, J. W., Apr 2009, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 4, p. 289-296 8 p.Research output: Contribution to journal › Review article › peer-review
31 Scopus citations -
2008
Actions of human telomerase beyond telomeres
Cong, Y. & Shay, J. W., Jul 2008, In: Cell Research. 18, 7, p. 725-732 8 p.Research output: Contribution to journal › Review article › peer-review
195 Scopus citations -
2007
Hallmarks of telomeres in ageing research
Shay, J. W. & Wright, W. E., Jan 2007, In: Journal of Pathology. 211, 2, p. 114-123 10 p.Research output: Contribution to journal › Review article › peer-review
165 Scopus citations -
Human diseases of telomerase dysfunction: Insights into tissue aging
Garcia, C. K., Wright, W. E. & Shay, J. W., Dec 2007, In: Nucleic acids research. 35, 22, p. 7406-7416 11 p.Research output: Contribution to journal › Review article › peer-review
129 Scopus citations -
Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells
Keith, W. N., Thomson, C. M., Howcroft, J., Maitland, N. J. & Shay, J. W., Aug 2007, In: Drug Discovery Today. 12, 15-16, p. 611-621 11 p.Research output: Contribution to journal › Review article › peer-review
21 Scopus citations -
2006
Telomerase therapeutics for cancer: Challenges and new directions
Shay, J. W. & Wright, W. E., Jul 2006, In: Nature Reviews Drug Discovery. 5, 7, p. 577-584 8 p.Research output: Contribution to journal › Review article › peer-review
387 Scopus citations -
2005
Fine-tuning the chromosome ends: The last base of human telomeres
Sfeir, A. J., Shay, J. W. & Wright, W. E., Nov 2005, In: Cell Cycle. 4, 11, p. 1467-1470 4 p.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
Mechanism-based combination telomerase inhibition therapy
Shay, J. W. & Wright, W. E., Jan 2005, In: Cancer Cell. 7, 1, p. 1-2 2 p.Research output: Contribution to journal › Review article › peer-review
45 Scopus citations -
Senescence and immortalization: Role of telomeres and telomerase
Shay, J. W. & Wright, W. E., 2005, In: Carcinogenesis. 26, 5, p. 867-874 8 p.Research output: Contribution to journal › Review article › peer-review
576 Scopus citations -
Telomerase as a therapeutic target in cancer
Gellert, G. C., Jackson, S. R., Dikmen, Z. G., Wright, W. E. & Shay, J. W., 2005, In: Drug Discovery Today: Disease Mechanisms. 2, 2, p. 159-164 6 p.Research output: Contribution to journal › Review article › peer-review
27 Scopus citations -
The longevity gender gap: are telomeres the explanation?
Aviv, A., Shay, J., Christensen, K. & Wright, W., Jun 8 2005, In: Science of aging knowledge environment : SAGE KE. 2005, 23, p. pe16Research output: Contribution to journal › Review article › peer-review
58 Scopus citations -
2004
Hallmarks of senescence in carcinogenesis and cancer therapy
Shay, J. W. & Roninson, I. B., Apr 12 2004, In: Oncogene. 23, 16 REV. ISS. 2, p. 2919-2933 15 p.Research output: Contribution to journal › Review article › peer-review
442 Scopus citations -
Telomeres are double-strand DNA breaks hidden from DNA damage responses
Shay, J. W. & Wright, W. E., May 21 2004, In: Molecular cell. 14, 4, p. 420-421 2 p.Research output: Contribution to journal › Review article › peer-review
22 Scopus citations -
The frequency of homologous recombination in human ALT cells
Bechter, O. E., Shay, J. W. & Wright, W. E., May 2004, In: Cell Cycle. 3, 5, p. 545-547 3 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
2003
Telomerase therapeutics: Telomeres recognized as a DNA damage signal
Shay, J. W., Oct 1 2003, In: Clinical Cancer Research. 9, 10 I, p. 3521-3525 5 p.Research output: Contribution to journal › Review article › peer-review
45 Scopus citations -
2002
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation
Ford, L. P., Wright, W. E. & Shay, J. W., Jan 21 2002, In: Oncogene. 21, 4 REV. ISS. 1, p. 580-583 4 p.Research output: Contribution to journal › Review article › peer-review
130 Scopus citations -
Historical claims and current interpretations of replicative aging
Wright, W. E. & Shay, J. W., 2002, In: Nature biotechnology. 20, 7, p. 682-688 7 p.Research output: Contribution to journal › Review article › peer-review
303 Scopus citations -
Oligonucleotide N3′→P5′ phosphoramidates as efficient telomerase inhibitors
Shea-Herbert, B., Pongracz, K., Shay, J. W. & Gryaznov, S. M., Jan 21 2002, In: Oncogene. 21, 1, p. 638-642 5 p.Research output: Contribution to journal › Review article › peer-review
115 Scopus citations -
Telomerase: A target for cancer therapeutics
Shay, J. W. & Wright, W. E., Oct 2002, In: Cancer Cell. 2, 4, p. 257-265 9 p.Research output: Contribution to journal › Review article › peer-review
303 Scopus citations -
Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again
Forsyth, N. R., Wright, W. E. & Shay, J. W., Jan 2002, In: Differentiation. 69, 4-5, p. 188-197 10 p.Research output: Contribution to journal › Review article › peer-review
298 Scopus citations -
Telomerase in cancer and aging
Granger, M. P., Wright, W. E. & Shay, J. W., 2002, In: Critical Reviews in Oncology/Hematology. 41, 1, p. 29-40 12 p.Research output: Contribution to journal › Review article › peer-review
140 Scopus citations -
Telomerase regulation: Not just flipping the switch
Aisner, D. L., Wright, W. E. & Shay, J. W., Feb 1 2002, In: Current Opinion in Genetics and Development. 12, 1, p. 80-85 6 p.Research output: Contribution to journal › Review article › peer-review
136 Scopus citations -
2001
Cellular senescence as a tumor-protection mechanism: The essential role of counting
Wright, W. E. & Shay, J. W., Feb 1 2001, In: Current Opinion in Genetics and Development. 11, 1, p. 98-103 6 p.Research output: Contribution to journal › Review article › peer-review
262 Scopus citations -
Forward: Aging and cancer: Are telomeres and telomerase the connection?
Shay, J. W. & Wright, W. E., 2001, In: Advances in Cell Aging and Gerontology. 8, C, p. 1-13 13 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Telomerase and cancer
Shay, J. W., Zou, Y., Hiyama, E. & Wright, W. E., 2001, In: Human molecular genetics. 10, 7, p. 677-685 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access362 Scopus citations