Research output per year
Research output per year
- 1 - 50 out of 483 results
Search results
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2024
A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer
Eglenen-Polat, B., Kowash, R. R., Huang, H. C., Siteni, S., Zhu, M., Chen, K., Bender, M. E., Mender, I., Stastny, V., Drapkin, B. J., Raj, P., Minna, J. D., Xu, L., Shay, J. W. & Akbay, E. A., Dec 2024, In: Nature communications. 15, 1, 672.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Mender, I., Siteni, S., Barron, S., Flusche, A. M., Kubota, N., Yu, C., Cornelius, C., Tedone, E., Maziveyi, M., Grichuk, A., Venkateswaran, N., Conacci-Sorrell, M., Hoshida, Y., Kang, R., Tang, D., Gryaznov, S. & Shay, J. W., Jun 1 2023, In: Molecular Cancer Therapeutics. 22, 6, p. 737-750 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs
Rosso, I., Jones-Weinert, C., Rossiello, F., Cabrini, M., Brambillasca, S., Munoz-Sagredo, L., Lavagnino, Z., Martini, E., Tedone, E., Garre’, M., Aguado, J., Parazzoli, D., Mione, M., Shay, J. W., Mercurio, C. & d’Adda di Fagagna, F., Dec 2023, In: Nature communications. 14, 1, 7086.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis
Ghayee, H. K., Xu, Y., Hatch, H., Brockway, R., Multani, A. S., Gu, T., Bollag, W. B., Turcu, A., Rainey, W. E., Rege, J., Nanba, K., Bhagwandin, V. J., Nwariaku, F., Stastny, V., Gazdar, A. F., Shay, J. W., Auchus, R. J. & Tevosian, S. G., Jan 2023, In: International journal of molecular sciences. 24, 1, 584.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
Bhat, P., Aksenova, V., Gazzara, M., Rex, E. A., Aslam, S., Haddad, C., Gao, S., Esparza, M., Cagatay, T., Batten, K., El Zahed, S. S., Arnaoutov, A., Zhong, H., Shay, J. W., Tolbert, B. S., Dasso, M., Lynch, K. W., García-Sastre, A. & Fontoura, B. M. A., Dec 2023, In: Nature communications. 14, 1, 2304.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly
Xie, Y., Gao, S., Zhang, K., Bhat, P., Clarke, B. P., Batten, K., Mei, M., Gazzara, M., Shay, J. W., Lynch, K. W., Angelos, A. E., Hill, P. S., Ivey, A. L., Fontoura, B. & Ren, Y., Aug 29 2023, In: Cell Reports. 42, 8, 112988.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2022
DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
Sepe, S., Rossiello, F., Cancila, V., Iannelli, F., Matti, V., Cicio, G., Cabrini, M., Marinelli, E., Alabi, B. R., di Lillo, A., Di Napoli, A., Shay, J. W., Tripodo, C. & d’Adda di Fagagna, F., Feb 3 2022, In: EMBO Reports. 23, 2, e53658.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure
Kiffer, F. C., Luitel, K., Tran, F. H., Patel, R. A., Guzman, C. S., Soler, I., Xiao, R., Shay, J. W., Yun, S. & Eisch, A. J., Feb 15 2022, In: Behavioural Brain Research. 419, 113677.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Nuclear speckle integrity and function require TAO2 kinase
Gao, S., Esparza, M., Dehghan, I., Aksenova, V., Zhang, K., Batten, K., Ferretti, M. B., Begg, B. E., Cagatay, T., Shay, J. W., Garcıa-Sastre, A., Goldsmith, E. J., Chen, Z. J., Dasso, M., Lynch, K. W., Cobb, M. H. & Fontoura, B. M. A., Jun 21 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 25, e2206046119.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer
Wong, C. C., Wu, J. L., Ji, F., Kang, W., Bian, X., Chen, H., Chan, L. S., Luk, S. T. Y., Tong, S., Xu, J., Zhou, Q., Liu, D., Su, H., Gou, H., Cheung, A. H. K., To, K. F., Cai, Z., Shay, J. W. & Yu, J., Dec 2022, In: Nature communications. 13, 1, 3971.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
The novel, telomerase-directed, telomere-targeted, anticancer agent 6-thio-dG (THIO) demonstrates potent activity and induces antitumor immunity in hepatocellular carcinoma (HCC) models
Shay, J., Mender, I., Siteni, S., Obrocea, M., Vitoc, V. & Gryaznov, S., Oct 2022, In: European Journal of Cancer. 174, p. S30-S31Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Imaging assay to probe the role of telomere length shortening on telomere-gene interactions in single cells
Zhang, N., Li, Y., Lai, T. P., Shay, J. W. & Danuser, G., Mar 2021, In: Chromosoma. 130, 1, p. 61-73 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Guan, J., Lu, C., Jin, Q., Lu, H., Chen, X., Tian, L., Zhang, Y., Ortega, J., Zhang, J., Siteni, S., Chen, M., Gu, L., Shay, J. W., Davis, A. J., Chen, Z. J., Fu, Y. X. & Li, G. M., Jan 11 2021, In: Cancer Cell. 39, 1, p. 109-121.e5Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer
Cen, B., Wei, J., Wang, D., Xiong, Y., Shay, J. W. & DuBois, R. N., Oct 14 2021, In: Oncogene. 40, 41, p. 5984-5992 9 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Repair of O6-carboxymethylguanine adducts by O6-methylguanine-DNA methyltransferase in human colon epithelial cells
Kostka, T., Empl, M. T., Seiwert, N., Geisen, S. M., Hoffmann, P., Adam, J., Seeger, B., Shay, J. W., Christmann, M., Sturla, S. J., Fahrer, J. & Steinberg, P., Aug 1 2021, In: Carcinogenesis. 42, 8, p. 1110-1118 9 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Short-term and long-term carcinogenic effects of food contaminants (4-hydroxynonenal and pesticides) on colorectal human cells: Involvement of genotoxic and non-genomic mechanisms
Arnaud, L. C., Gauthier, T., Le Naour, A., Hashim, S., Naud, N., Shay, J. W., Pierre, F. H., Boutet-Robinet, E. & Huc, L., Sep 1 2021, In: Cancers. 13, 17, 4337.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell expression landscape of SARS-CoV-2 receptor ACE2 and host proteases in normal and malignant lung tissues from pulmonary adenocarcinoma patients
Han, G., Sinjab, A., Hara, K., Treekitkarnmongkol, W., Brennan, P., Chang, K., Bogatenkova, E., Sanchez-Espiridion, B., Behrens, C., Solis, L. M., Gao, B., Girard, L., Zhang, J., Sepesi, B., Cascone, T., Byers, L. A., Gibbons, D. L., Chen, J., Moghaddam, S. J., Ostrin, E. J., & 11 others, Mar 2 2021, In: Cancers. 13, 6, p. 1-13 13 p., 1250.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Telomere erosion in human pluripotent stem cells leads to atr-mediated mitotic catastrophe
Vessoni, A. T., Zhang, T., Quinet, A., Jeong, H. C., Munroe, M., Wood, M., Tedone, E., Vindigni, A., Shay, J. W., Greenberg, R. A. & Batista, L. F. Z., 2021, In: Journal of Cell Biology. 220, 6, e202011014.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes
Lai, T. P., Simpson, M., Patel, K., Verhulst, S., Noh, J., Roche, N., Heller, D., Guirguis, G., Shay, J. W., Herbig, U. & Aviv, A., Dec 2021, In: Scientific reports. 11, 1, 5115.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2020
Chemical intervention of influenza virus mRNA nuclear export
Esparza, M., Mor, A., Niederstrasser, H., White, K., White, A., Zhang, K., Gao, S., Wang, J., Liang, J., Sho, S., Sakthivel, R., Sathe, A. A., Xing, C., Muñoz-Moreno, R., Shay, J. W., García-Sastre, A., Ready, J., Posner, B. & Fontoura, B. M. A., Apr 1 2020, In: PLoS pathogens. 16, 4, e1008407.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase
Abdisalaam, S., Bhattacharya, S., Mukherjee, S., Sinha, D., Srinivasan, K., Zhu, M., Akbay, E. A., Sadek, H. A., Shay, J. W. & Asaithamby, A., Aug 7 2020, In: Journal of Biological Chemistry. 295, 32, p. 11144-11160 17 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention
Luitel, K., Kim, S. B., Barron, S., Richardson, J. A. & Shay, J. W., Feb 2020, In: Life Sciences in Space Research. 24, p. 108-115 8 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
MAP9 loss triggers chromosomal instability, initiates colorectal tumorigenesis, and is associated with poor survival of patients with colorectal cancer
Wang, S., Huang, J., Li, C., Zhao, L., Wong, C. C., Zhai, J., Zhou, Y., Deng, W., Zeng, Y., Gao, S., Zhang, Y., Wang, G., Guan, X. Y., Wei, H., Wong, S. H., He, H. H., Shay, J. W. & Yu, J., Feb 1 2020, In: Clinical Cancer Research. 26, 3, p. 746-757 12 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings
Peters-Hall, J. R., Min, J., Tedone, E., Sho, S., Siteni, S., Mender, I. & Shay, J. W., Jan 1 2020, In: FASEB Journal. 34, 1, p. 386-398 13 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
SLC43A3 is a biomarker of sensitivity to the telomeric DNA damage mediator 6-thio-2′-deoxyguanosine
Mender, I., Batten, K., Peyton, M., Vemula, A., Cornelius, C., Girard, L., Gao, B., Minna, J. D. & Shay, J. W., Mar 1 2020, In: Cancer research. 80, 5, p. 929-936 8 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
Mender, I., Zhang, A., Ren, Z., Han, C., Deng, Y., Siteni, S., Li, H., Zhu, J., Vemula, A., Shay, J. W. & Fu, Y. X., Sep 14 2020, In: Cancer Cell. 38, 3, p. 400-411.e6Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
2019
Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs)
Sayed, M. E., Cheng, A., Yadav, G. P., Ludlow, A. T., Shay, J. W., Wright, W. E. & Jiang, Q. X., Jul 26 2019, In: Journal of Biological Chemistry. 294, 30, p. 11579-11596 18 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52
Min, J., Wright, W. E. & Shay, J. W., Jul 2019, In: Genes and Development. 33, 13-14, p. 814-827 14 p.Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations -
Decellularized mice colons as models to study the contribution of the extracellular matrix to cell behavior and colon cancer progression
Alabi, B. R., LaRanger, R. & Shay, J. W., Dec 2019, In: Acta Biomaterialia. 100, p. 213-222 10 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
Hao, Y. H., Lafita-Navarro, M. C., Zacharias, L., Borenstein-Auerbach, N., Kim, M., Barnes, S., Kim, J., Shay, J., Deberardinis, R. J. & Conacci-Sorrell, M., Oct 17 2019, In: Cell Communication and Signaling. 17, 1, 129.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells
Martin, O. C. B., Bergonzini, A., D'Amico, F., Chen, P., Shay, J. W., Dupuy, J., Svensson, M., Masucci, M. G. & Frisan, T., Dec 1 2019, In: Cellular Microbiology. 21, 12, e13099.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
In perspective: An update on telomere targeting in cancer
Sugarman, E. T., Zhang, G. & Shay, J. W., Sep 2019, In: Molecular Carcinogenesis. 58, 9, p. 1581-1588 8 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer
Venkateswaran, N., Lafita-Navarro, M. C., Hao, Y. H., Kilgore, J. A., Perez-Castro, L., Braverman, J., Borenstein-Auerbach, N., Kim, M., Lesner, N. P., Mishra, P., Brabletz, T., Shay, J. W., DeBerardinis, R. J., Williams, N. S., Yilmaz, O. H. & Conacci-Sorrell, M., Sep 1 2019, In: Genes and Development. 33, 17-18, p. 1236-1251 16 p.Research output: Contribution to journal › Article › peer-review
Open Access121 Scopus citations -
Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution
O'Hara, R., Tedone, E., Ludlow, A., Huang, E., Arosio, B., Mari, D. & Shay, J. W., 2019, In: Genome Research. 29, 11, p. 1878-1888 11 p.Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians
Tedone, E., Huang, E., O’Hara, R., Batten, K., Ludlow, A. T., Lai, T. P., Arosio, B., Mari, D., Wright, W. E. & Shay, J. W., Feb 2019, In: Aging Cell. 18, 1, e12859.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Telomeres and telomerase: three decades of progress
Shay, J. W. & Wright, W. E., May 1 2019, In: Nature Reviews Genetics. 20, 5, p. 299-309 11 p.Research output: Contribution to journal › Article › peer-review
488 Scopus citations -
Transient introduction of human telomerase mRNA improves hallmarks of progeria cells
Li, Y., Zhou, G., Bruno, I. G., Zhang, N., Sho, S., Tedone, E., Lai, T. P., Cooke, J. P. & Shay, J. W., Aug 2019, In: Aging Cell. 18, 4, e12979.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2018
Cholesterol depletion by tasin-1 induces apoptotic cell death through the er stress/ ros/jnk signaling in colon cancer cells
Zhang, L., Kim, S. B., Luitel, K. & Shay, J. W., May 2018, In: Molecular Cancer Therapeutics. 17, 5, p. 943-951 9 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma
Reyes-Uribe, P., Adrianzen-Ruesta, M. P., Deng, Z., Echevarria-Vargas, I., Mender, I., Saheb, S., Liu, Q., Altieri, D. C., Murphy, M. E., Shay, J. W., Lieberman, P. M. & Villanueva, J., Jul 26 2018, In: Oncogene. 37, 30, p. 4058-4072 15 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Expression of contactin 4 is associated with malignant behavior in pheochromocytomas and paragangliomas
Evenepoel, L., Van Nederveen, F. H., Oudijk, L., Papathomas, T. G., Restuccia, D. F., Belt, E. J. T., De Herder, W. W., Feelders, R. A., Franssen, G. J. H., Hamoir, M., Maiter, D., Ghayee, H. K., Shay, J. W., Perren, A., Timmers, H. J. L. M., Van Eeden, S., Vroonen, L., Aydin, S., Robledo, M., Vikkula, M., & 4 others, 2018, In: Journal of Clinical Endocrinology and Metabolism. 103, 1, p. 46-55 10 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Induced telomere damage to treat telomerase expressing therapy-resistant pediatric brain tumors
Sengupta, S., Sobo, M., Lee, K., Kumar, S. S., White, A. R., Mender, I., Fuller, C., Chow, L. M. L., Fouladi, M., Shay, J. W. & Drissi, R., Jul 2018, In: Molecular Cancer Therapeutics. 17, 7, p. 1504-1514 11 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Induction of telomere dysfunction prolongs disease control of therapy-resistant melanoma
Zhang, G., Wu, L. W., Mender, I., Barzily-Rokni, M., Hammond, M. R., Ope, O., Cheng, C., Vasilopoulos, T., Randell, S., Sadek, N., Beroard, A., Xiao, M., Tian, T., Tan, J., Saeed, U., Sugarman, E., Krepler, C., Brafford, P., Sproesser, K., Murugan, S., & 24 others, Oct 1 2018, In: Clinical Cancer Research. 24, 19, p. 4771-4784 14 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD)
Kim, W. & Shay, J. W., Jan 2018, In: Differentiation. 99, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function
Peters-Hall, J. R., Coquelin, M. L., Torres, M. J., Laranger, R., Alabi, B. R., Sho, S., Calva-Moreno, J. F., Thomas, P. J. & Shay, J. W., Aug 2018, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 2, p. L313-L327Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
Ludlow, A. T., Wong, M. S., Robin, J. D., Batten, K., Yuan, L., Lai, T. P., Dahlson, N., Zhang, L., Mender, I., Tedone, E., Sayed, M. E., Wright, W. E. & Shay, J. W., Dec 1 2018, In: Nature communications. 9, 1, 3112.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Proton radiation-induced cancer progression
Luitel, K., Bozeman, R., Kaisani, A., Kim, S. B., Barron, S., Richardson, J. A. & Shay, J. W., Nov 2018, In: Life Sciences in Space Research. 19, p. 31-42 12 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells
Laranger, R., Peters-Hall, J. R., Coquelin, M., Alabi, B. R., Chen, C. T., Wright, W. E. & Shay, J. W., Apr 2018, In: Tissue Engineering - Part A. 24, 7-8, p. 559-568 10 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Reflections on telomere dynamics and ageing-related diseases in humans
Aviv, A. & Shay, J. W., Mar 5 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1741, 20160436.Research output: Contribution to journal › Article › peer-review
Open Access115 Scopus citations -
Silencing the snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells
Walser, T. C., Jing, Z., Tran, L. M., Lin, Y. Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L. X., Sharma, S., Lee, M. H., Belperio, J. A., Ooi, A. T., Gomperts, B. N., Shay, J. W., Larsen, J. E., Minna, J. D., Hong, L. S., Fishbein, M. C. & Dubinett, S. M., Apr 15 2018, In: Cancer research. 78, 8, p. 1986-1999 14 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance
Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 2018, In: Neoplasia (United States). 20, 8, p. 826-837 12 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations