Research output per year
Research output per year
- 16 results
Search results
-
2024
Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines
Wang, W., Ranjan, A., Zhang, W., Liang, Q., MacMillan, K. S., Chapman, K., Wang, X., Chandrasekaran, P., Williams, N. S., Rosenbaum, D. M. & De Brabander, J. K., Feb 1 2024, In: Bioorganic and Medicinal Chemistry Letters. 99, 129624.Research output: Contribution to journal › Article › peer-review
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2023
Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice
Sun, Y., Ranjan, A., Tisdale, R., Ma, S. C., Park, S., Haire, M., Heu, J., Morairty, S. R., Wang, X., Rosenbaum, D. M., Williams, N. S., De Brabander, J. K. & Kilduff, T. S., Aug 2023, In: Journal of Sleep Research. 32, 4, e13839.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Molecular mechanism of fatty acid activation of FFAR1
Kumari, P., Inoue, A., Chapman, K., Lian, P. & Rosenbaum, D. M., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2219569120.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Orexin A, an amphipathic α-helical neuropeptide involved in pleiotropic functions in the nervous and immune systems: Synthetic approach and biophysical studies of the membrane-bound state
Ball, H. L., Said, H., Chapman, K., Fu, R., Xiong, Y., Burk, J. A., Rosenbaum, D., Veneziano, R. & Cotten, M. L., Jun 2023, In: Biophysical Chemistry. 297, 107007.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2022
Molecular basis for ligand modulation of the cannabinoid CB1 receptor
Ramesh, K. & Rosenbaum, D. M., Jul 2022, In: British Journal of Pharmacology. 179, 14, p. 3487-3495 9 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Molecular mechanism of the wake-promoting agent TAK-925
Yin, J., Kang, Y., McGrath, A. P., Chapman, K., Sjodt, M., Kimura, E., Okabe, A., Koike, T., Miyanohana, Y., Shimizu, Y., Rallabandi, R., Lian, P., Bai, X., Flinspach, M., De Brabander, J. K. & Rosenbaum, D. M., Dec 2022, In: Nature communications. 13, 1, 2902.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2021
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Xiao, P., Yan, W., Gou, L., Zhong, Y. N., Kong, L., Wu, C., Wen, X., Yuan, Y., Cao, S., Qu, C., Yang, X., Yang, C. C., Xia, A., Hu, Z., Zhang, Q., He, Y. H., Zhang, D. L., Zhang, C., Hou, G. H., Liu, H., & 9 others, Feb 18 2021, In: Cell. 184, 4, p. 943-956.e18Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations -
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing
Kober, D. L., Radhakrishnan, A., Goldstein, J. L., Brown, M. S., Clark, L. D., Bai, X. C. & Rosenbaum, D. M., Jul 8 2021, In: Cell. 184, 14, p. 3689-3701.e22Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2020
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
Kober, D. L., Xu, S., Li, S., Bajaj, B., Liang, G., Rosenbaum, D. M. & Radhakrishnan, A., Nov 10 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 45, p. 28080-28091 12 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Structural and functional diversity calls for a new classification of ABC transporters
Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y., & 23 others, Dec 2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p.Research output: Contribution to journal › Article › peer-review
Open Access152 Scopus citations -
Structure-based development of a subtype-selective orexin 1 receptor antagonist
Hellmann, J., Drabek, M., Yin, J., Gunera, J., Pröll, T., Kraus, F., Langmead, C. J., Hübner, H., Weikert, D., Kolb, P., Rosenbaum, D. M. & Gmeiner, P., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 18059-18067 9 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor
Gunera, J., Baker, J. G., Van Hilten, N., Rosenbaum, D. M. & Kolb, P., Oct 8 2020, In: Journal of Medicinal Chemistry. 63, 19, p. 11045-11053 9 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane
Yin, J., Chen, K. Y. M., Clark, M. J., Hijazi, M., Kumari, P., Bai, X. C., Sunahara, R. K., Barth, P. & Rosenbaum, D. M., Aug 6 2020, In: Nature. 584, 7819, p. 125-129 5 p.Research output: Contribution to journal › Article › peer-review
Open Access120 Scopus citations -
2019
An improved yeast surface display platform for the screening of nanobody immune libraries
Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In: Scientific reports. 9, 1, 382.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris
Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Dec 1 2019, In: Journal of biomolecular NMR. 73, 12, p. 687-697 11 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor
Shao, Z., Yan, W., Chapman, K., Ramesh, K., Ferrell, A. J., Yin, J., Wang, X., Xu, Q. & Rosenbaum, D. M., Dec 1 2019, In: Nature chemical biology. 15, 12, p. 1199-1205 7 p.Research output: Contribution to journal › Article › peer-review
106 Scopus citations