BP-Lab Rosenbaum

Research output

Research output per year 2019 2019 2020 2023 2024

• 16 Article
• 1 Letter

Research output per year

Research output per year

Search results

• 2024

  Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines

  Wang, W., Ranjan, A., Zhang, W., Liang, Q., MacMillan, K. S., Chapman, K., Wang, X., Chandrasekaran, P., Williams, N. S., Rosenbaum, D. M. & De Brabander, J. K., Feb 1 2024, In: Bioorganic and Medicinal Chemistry Letters. 99, 129624.

  Research output: Contribution to journal › Article › peer-review

  • Orexin Receptors 100%
  • Imines 99%
  • pyridine 86%
  • imidazole 86%
  • Ether 74%
• 2023

  Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice

  Sun, Y., Ranjan, A., Tisdale, R., Ma, S. C., Park, S., Haire, M., Heu, J., Morairty, S. R., Wang, X., Rosenbaum, D. M., Williams, N. S., De Brabander, J. K. & Kilduff, T. S., Aug 2023, In: Journal of Sleep Research. 32, 4, e13839.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orexin Receptors 100%
  • Orexins 87%
  • Cataplexy 48%
  • Sleep 43%
  • Electroencephalography 28%
  1 Scopus citations

• Molecular mechanism of fatty acid activation of FFAR1

  Kumari, P., Inoue, A., Chapman, K., Lian, P. & Rosenbaum, D. M., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2219569120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GTP-Binding Proteins 100%
  • TAK-875 97%
  • Fatty Acids 85%
  • Ligands 70%
  • Hormones 70%
  4 Scopus citations

• Orexin A, an amphipathic α-helical neuropeptide involved in pleiotropic functions in the nervous and immune systems: Synthetic approach and biophysical studies of the membrane-bound state

  Ball, H. L., Said, H., Chapman, K., Fu, R., Xiong, Y., Burk, J. A., Rosenbaum, D., Veneziano, R. & Cotten, M. L., Jun 2023, In: Biophysical Chemistry. 297, 107007.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orexin A 100%
  • Orexins 64%
  • Neuropeptides 50%
  • Nervous System 40%
  • Immune System 39%
  1 Scopus citations

• Reply to: The G protein preference of orexin receptors is currently an unresolved issue

  Yin, J., Kang, Y., McGrath, A. P., Chapman, K., Sjodt, M., Kimura, E., Okabe, A., Koike, T., Miyanohana, Y., Shimizu, Y., Rallabandi, R., Lian, P., Bai, X., Flinspach, M., De Brabander, J. K. & Rosenbaum, D. M., Dec 2023, In: Nature communications. 14, 1, 3163.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• 2022

  Molecular basis for ligand modulation of the cannabinoid CB₁ receptor

  Ramesh, K. & Rosenbaum, D. M., Jul 2022, In: British Journal of Pharmacology. 179, 14, p. 3487-3495 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cannabinoid Receptor CB1 100%
  • Ligands 55%
  • Cannabinoid Receptor CB2 27%
  • Anniversaries and Special Events 24%
  • Endocannabinoids 23%
  5 Scopus citations

• Molecular mechanism of the wake-promoting agent TAK-925

  Yin, J., Kang, Y., McGrath, A. P., Chapman, K., Sjodt, M., Kimura, E., Okabe, A., Koike, T., Miyanohana, Y., Shimizu, Y., Rallabandi, R., Lian, P., Bai, X., Flinspach, M., De Brabander, J. K. & Rosenbaum, D. M., Dec 2022, In: Nature communications. 13, 1, 2902.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Wake-Promoting 100%
  • Wakefulness-Promoting Agents 89%
  • Orexin Receptors 75%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 55%
  • wakes 48%
  12 Scopus citations
• 2021

  Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

  Xiao, P., Yan, W., Gou, L., Zhong, Y. N., Kong, L., Wu, C., Wen, X., Yuan, Y., Cao, S., Qu, C., Yang, X., Yang, C. C., Xia, A., Hu, Z., Zhang, Q., He, Y. H., Zhang, D. L., Zhang, C., Hou, G. H., Liu, H., & 9 othersZhu, L., Fu, P., Yang, S., Rosenbaum, D. M., Sun, J. P., Du, Y., Zhang, L., Yu, X. & Shao, Z., Feb 18 2021, In: Cell. 184, 4, p. 943-956.e18

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Allosteric Regulation 100%
  • GTP-Binding Proteins 67%
  • Agonist 64%
  • Ligands 47%
  • Drug Design 38%
  78 Scopus citations

• Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing

  Kober, D. L., Radhakrishnan, A., Goldstein, J. L., Brown, M. S., Clark, L. D., Bai, X. C. & Rosenbaum, D. M., Jul 8 2021, In: Cell. 184, 14, p. 3689-3701.e22

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cholesterol 100%
  • Sterol Regulatory Element Binding Proteins 67%
  • Endoplasmic Reticulum 64%
  • Sterol 61%
  • Sterols 52%
  13 Scopus citations
• 2020

  Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis

  Kober, D. L., Xu, S., Li, S., Bajaj, B., Liang, G., Rosenbaum, D. M. & Radhakrishnan, A., Nov 10 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 45, p. 28080-28091 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sterol Regulatory Element Binding Proteins 100%
  • Cholesterol 48%
  • Homeostasis 48%
  • Endoplasmic Reticulum 21%
  • Exons 12%
  19 Scopus citations

• Structural and functional diversity calls for a new classification of ABC transporters

  Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y., & 23 othersLewinson, O., Lill, R., Martinoia, E., Murakami, S., Pinkett, H. W., Poolman, B., Rosenbaum, D., Sarkadi, B., Schmitt, L., Schneider, E., Shi, Y., Shyng, S. L., Slotboom, D. J., Tajkhorshid, E., Tieleman, D. P., Ueda, K., Váradi, A., Wen, P. C., Yan, N., Zhang, P., Zheng, H., Zimmer, J. & Tampé, R., Dec 2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ATP-Binding Cassette Transporters 100%
  • Nucleotides 22%
  • Adenosine Triphosphate 21%
  152 Scopus citations

• Structure-based development of a subtype-selective orexin 1 receptor antagonist

  Hellmann, J., Drabek, M., Yin, J., Gunera, J., Pröll, T., Kraus, F., Langmead, C. J., Hübner, H., Weikert, D., Kolb, P., Rosenbaum, D. M. & Gmeiner, P., Jul 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 18059-18067 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orexin Receptor Antagonists 100%
  • Orexins 80%
  • suvorexant 74%
  • Drug Design 47%
  • Ligands 43%
  28 Scopus citations

• Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor

  Gunera, J., Baker, J. G., Van Hilten, N., Rosenbaum, D. M. & Kolb, P., Oct 8 2020, In: Journal of Medicinal Chemistry. 63, 19, p. 11045-11053 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orexin Receptors 100%
  • Ligands 47%
  • Agonist 31%
  • Ligand 29%
  • G-Protein-Coupled Receptors 22%
  7 Scopus citations

• Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

  Yin, J., Chen, K. Y. M., Clark, M. J., Hijazi, M., Kumari, P., Bai, X. C., Sunahara, R. K., Barth, P. & Rosenbaum, D. M., Aug 6 2020, In: Nature. 584, 7819, p. 125-129 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Membrane Lipids 100%
  • Dopamine 76%
  • Membranes 53%
  • GTP-Binding Proteins 44%
  • Phospholipids 40%
  120 Scopus citations
• 2019

  An improved yeast surface display platform for the screening of nanobody immune libraries

  Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In: Scientific reports. 9, 1, 382.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Single-Domain Antibodies 100%
  • Libraries 59%
  • Yeasts 54%
  • Acyl Carrier Protein 15%
  • Antigens 12%
  57 Scopus citations

• Improved strategy for isoleucine ¹H/¹³C methyl labeling in Pichia pastoris

  Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Dec 1 2019, In: Journal of biomolecular NMR. 73, 12, p. 687-697 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pichia 100%
  • Isoleucine 98%
  • Protein 32%
  • Costs and Cost Analysis 29%
  • Proteins 29%
  9 Scopus citations

• Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

  Shao, Z., Yan, W., Chapman, K., Ramesh, K., Ferrell, A. J., Yin, J., Wang, X., Xu, Q. & Rosenbaum, D. M., Dec 1 2019, In: Nature chemical biology. 15, 12, p. 1199-1205 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-chloro-3-ethyl-1H-indole-2-carboxylic acid (2-(4-piperidin-1-yl-phenyl)ethyl)amide 100%
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 72%
  • Cannabinoid Receptor CB1 59%
  • Cannabinoids 53%
  • G-Protein-Coupled Receptors 46%
  106 Scopus citations